Volume 99, Nº 6 (2020)

Capa

PROBLEM-SOLVING ARTICLES

Mineral oils as the pressing problem of hygienic safety of a cardboard packing

Mikheeva A., Zaritskaya E., Iakubova I., Alikbaeva L., Deinega A.

Resumo

Introduction. Providing sanitary and epidemiological safety for the secure packing production is a mandatory requirement for all manufacturers of food packing materials, no matter if it is in direct contact with foodstuff or not. However, hazardous chemicals can penetrate products from recycled materials, as well as from the moving parts of any packing equipment. Hence, the problem of packing material contamination by mineral oils, which can occur while using recycled materials, printing inks for making inscriptions and pictures, lubricating components of equipment, is of on-going interest. If packing materials are contaminated by mineral oils adverse chemicals can penetrate the foodstuff from the packing. Current packing safety requirements of European and Customs Unions differ in certain issues, in particular, hygienic regulation of mineral oils. Determination and assessment of mineral oil concentration are not regulated by Technical Regulation of the Customs Union 005/2011 “On Packing Safety” (TP TC 005/2011) in contrast to the requirements of European Union regulations which state allowable concentration and safe level of hydrocarbons in packing.

Material and Methods. 23 samples of cardboard packing from various manufacturers were studied, 10 of them containing wastepaper, 9 containing cellulose materials, and 4 samples being produced without recycled materials. The level of mineral oil migration into the air or aquatic simulated environments was determined. The studies were carried out at the “Arbitrazh” chemical and analytical Center of the D.I. Mendeleev All-Russian Scientific Research Institute, by gas chromatography using Perkin Elmer Auto System. Supelco standard was used for getting calibration characteristics, i.e.: a mixture of normal structure aliphatic hydrocarbons from C6 to C44, mass parts of certain hydrocarbons being from 1 to 12% of the masses.

Results. All studied cardboard packing samples were found to contain mineral oil in the hydrocarbon range of C7-C17. Mineral oil migration levels from 19 cardboard packing samples into simulated air and aquatic environments were determined.

Conclusion. Hygienic safety regulation issues of foodstuff cardboard packing are relevant and require further research. It is reasonable to include mineral oils into the list of regulated sanitary-epidemiologic safety indices, and standard values of chemicals releasing from food-contacting packing into the list of monitored indices TP TC 005/2011.

Hygiene and Sanitation. 2020;99(6):526-530
pages 526-530 views

Gender features of occupational pathology in the Russian Arctic

Syurin S., Frolova N.

Resumo

Introduction. An interest in studying the gender characteristics of occupational pathology is determined by increasing economic activity in the Arctic and the upcoming expansion of women’s access to occupations with harmful working conditions.

The purpose of the study was to carry out a comparative investigation of working conditions and occupational pathology among male and female workers at enterprises in the Arctic.

Material and methods. The data of socio-hygienic monitoring “Working conditions and occupational morbidity” of the population of the Russian Arctic in 2007-2018 were studied.

Results and discussion. 92.6% of occupational diseases have been established to occur in men due to more harmful working conditions (fibrogenic aerosols, noise, whole-body, and hand-arm vibration, the severity of labor). The risk of their occurrence in 2018 was higher than in 2007 (RR = 1.71; CI 1.51-1.93) and higher than in women (RR = 9.45; CI 7.19-12.4). Unlike men, 48.8% of women worked at facilities of the first group of sanitary and epidemiological welfare (satisfactory conditions) and they had in 2007-2018 a relatively stable number of newly diagnosed occupational diseases. The risk of occupational pathology in women in 2018 and 2007 did not change significantly (RR = 1.07; CI 0.73-1.59). In the structure of occupational diseases in men, the first places are occupied by vibration disease (24.2%), sensorineural hearing loss (20.3%) and radiculopathy (20.1%), and in women - myofibrosis of the forearms (21.2%), radiculopathy(13.7%) and chronic bronchitis (13.4%).

Conclusion. Reducing exposure to physical overloads, fibrogenic aerosols, noise, vibration, and chemical factors should be a priority preventive direction at enterprises in the Arctic, especially among male workers whose occupational morbidity rate tends to increase.

Hygiene and Sanitation. 2020;99(6):531-537
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ENVIRONMENTAL HYGIENE

National and international experience of hygienic regulation of aircraft noise (literature review)

Kriyt V., Friedman K., Sladkova Y., Volchkova O., Kuznetsova E.

Resumo

In the modern world, in the era of global industrialization, urbanization, and digitalization, providing safe living conditions is getting increasingly important. At the same time, the balance between providing comfort, economic expedience, and safety is an extremely important aspect. Development of technologies in the aviation industry, expansion of cities and their approaching to airports, as well as increased migration and tourist flows are the main challenges to ensuring a safe human environment. Currently, noise pollution, which is one of the main environmental health risk factors, is a serious public health problem. According to WHO Guidelines, air transport noise takes the first place for its annoying effect on the population. According to the European Guidelines, a cause-effect relationship between night noise exposure and health status change has been identified. This paper analyzes national and foreign procedural and technical approaches to the regulation and assessment of aircraft noise in residential areas in the vicinity of airports. The sanitary rules СП 2.1.8.3565-193 currently in force on the territory of the Russian Federation regulate the assessment of aircraft noise for compliance with allowable levels by the equivalent sound level standard for daytime and nighttime established for residential areas. This approach is harmonized with international legislation; however, regulatory values presented in the new sanitary rules are both the same for all residential areas and the most stringent in comparison with the standards in countries with highly developed aviation worldwide.
Hygiene and Sanitation. 2020;99(6):538-544
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Comparative assessment of approaches to human biomonitoring problem by national and foreign researchers (literature review)

Markova O., Shilov V., Kuznetsov A., Metelitsa N.

Resumo

Environmental safety is one of the sustainable development priorities of the Russian Federation. Increasing chemical pollutant emissions resulting from activities of industry, power engineering, traffic, and capital construction facilities into the environment cause both human life and health hazard risks. The object of this study was identifying approaches to harmonization of European and Russian human biomonitoring systems, which contributes to an assessment of harmful environmental chemical pollutant effects on human health. International and Russian regulatory legal acts, procedural documents were used as study materials, a set of general research methods was applied. Major problems that arise when assessing chemical pollutant exposures using human biomonitoring methods (HBM) are considered. The analysis of procedural materials of Russian Federation and European countries used in HBM revealed certain imperfections of Russian regulatory and procedural framework. Challenges in biomonitoring study are shown as follows: the choice of an informative biomarker and biological material; lack of standardized sampling techniques, harmonized methods for the analysis of biological materials, presentation of results, determination of allowable exposure levels. These discrepancies result in incommensurate results reducing reliability and significance levels of epidemiological studies. The paper summarizes international research experience in European countries, which could be the basis for the development of regulations for carrying out HBM in the Russian Federation. This document should be harmonized following the provisions of European documents, be terminologically uniform.
Hygiene and Sanitation. 2020;99(6):545-550
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Hygienic aspects of evaluating the process of creating a comfortable urban environment

Kopytenkova O., Levanchuk A., Ryabets V.

Resumo

Introduction. The national programs focus on solving social and economic problems. At the same time, the hygienic characteristics of the urban environment that determine living conditions are not fully included in the documents regulating the formation of the urban environment.

Materials and methods. The paper provides a content analysis of the current normative and methodological literature recommended for use in assessing the “formation of a comfortable urban environment” in Russian localities.

Results. Currently, existing methods for assessing the “comfort of the urban environment” (methodology for forming the urban environment quality index dated March 23, 2019, No. 510-R) and “quality of the urban living environment” (methodology for assessing the quality of the urban living environment dated September 9, 2013, 371) are not suitable for determining the development strategy of the country’s territories because the assessment procedure does not include key hygienic indices of the comfort of the natural environment and living conditions of the population, which allow citizens to meet housing needs and ensure a high quality of life in General, including the birth of healthy children, maintaining the health of the adult population and preventing premature mortality.

Conclusion. The urban environment integrates a variety of inter-level relations of various types (economic, social, cultural, etc.). It is intended to study it as a multi-level structure, for this purpose, it is necessary to use a hierarchical approach. To implement this approach, it is recommended to take into account the indices of various groups that affect the comfort of the urban environment and are directly related to the hygienic characteristics of the territory: A-climatogeographic; B-demographic; C-social; D-economic; E - urban planning; F - indices of transport infrastructure; G-environmental quality indices.

Hygiene and Sanitation. 2020;99(6):551-556
pages 551-556 views

Analysis of design decisions on establishing an aerodrome territory based on the electromagnetic factor

Nikitina V., Kalinina N., Lyashko G., Pankina E., Plekhanov V.

Resumo

Introduction. Under the regulations for civil aviation aerodromes, aerodrome territories (AT) are established. The analysis of the literature data shows that when considering the hygienic aspects of the operation of airfields, the authors focus on aviation noise and pollutants in the environment.

The purpose of the study: to analyze the design documentation for the establishment of the AT of many civil aviation aerodromes to study the effects of electromagnetic fields of the radio frequency range created by antennas of modern transmitting radio engineering objects (TREO).

Materials and methods. We studied regulatory documents on the procedure for establishing and using aerodrome territories, radio engineering support for airfields, technical characteristics and operating modes of modern radio equipment, and regulatory documents for ensuring electromagnetic safety of the population. The analysis of the project documentation for the organization of the aerodrome territory on the electromagnetic effects of seven civil aviation airfields was carried out.

Results. The study found the electromagnetic environment in an open area to depend on the power of the radio object, the frequency range, the height of the antenna installation, the radiation pattern in the vertical and horizontal plane, and the combination of two survey radars in one position. Sanitary protection zones and restricted areas for communication and navigation facilities are located within the technical territory of the airfield. Zones of restriction of radar objects fall into the seventh subzone of the AT, established by the noise factor.

Conclusion. According to regulatory documents, the justification of the boundaries of the seventh subzone of the AT of civil aviation airfields is established by the factor of noise and electro-magnetic effects, and air pollution. The experience of reviewing the project documentation for the establishment of near-aerodrome territories for electromagnetic effects shows that the zone of restriction of powerful radars can influence the formation of the seventh subzone of the AT. If the restriction zones go beyond the boundaries of the aerodrome land plot, then restrictions on the use of real estate objects and activities are imposed on the territories that fall within the zone.

Hygiene and Sanitation. 2020;99(6):557-562
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About the question of the assessment of the drinking water quality in centralized water systems in the current conditions

Novikova Y., Friedman K., Fedorov V., Kovshov A., Tikhonova N., Myasnikov I.

Resumo

Introduction. Regulation of drinking water quality is a very important area of health care and improving the quality of life of the population of the Russian Federation.

The aim of this work is the development a model for the assessment of the drinking water quality and calculating the share of the population, including urban, provided with high-quality drinking water from centralized water supply systems, taking into account new methodological approaches to the evaluation of the quality of drinking water using the example of water supply to settlements in the Leningrad Region.

Material and methods. The data on the organization of centralized cold water supply systems and monitoring systems for drinking water quality and the results of laboratory studies of drinking water quality in the cities of Volkhov, Svetogorsk, Slantsy, Tosno were studied. Statistical processing of the results was performed, the categories of quality of drinking water supplied to the population were determined, the number of the population provided with high-quality drinking water from the water supply system was calculated in accordance with Guidelines 2.1.4.0143-19.

Results. In 2018, 100% of the population was provided with quality drinking water only in the city of Slantsy. In the city of Tosno, this index reached of 83.5%. In the cities of Volkhov and Svetogorsk, drinking water was rated as low-quality. But it is worth noting that in the cities of Volkhov and Slantsy laboratory tests were carried out at 2 points, in the city of Svetogorsk - only at the 1 point, which, given the number of residents, is not enough. For an objective assessment of the state of drinking water and the development of measures aimed at improving its quality, it is necessary to increase the number of monitoring points, as well as to include the results of control and supervision measures and production laboratory control conducted by water supply organizations in the volume of laboratory information.

Conclusion. The proposed model allows us to assess the drinking water quality in centralized water supply systems and the proportion of the population, including urban, provided with quality drinking water at the level of the water supply system, settlement, municipal district (urban district), subject of the Russian Federation

Hygiene and Sanitation. 2020;99(6):563-568
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Analysis of the structure of acute poisoning with modern psychoactive substances

Sinenchenko A., Lodyagin A., Shilov M., Batotsyrenov B., Balabanova O., Shikalova I.

Resumo

Introduction. The article presents the epidemiological analysis of the structure of acute poisonings with modern psychoactive substances.

The aim of the study was to analyze the structure of acute poisonings with modern psychoactive substances among patients hospitalized in General hospitals for 2019 to improve preventive measures.

Material and methods. There were used data obtained from the consolidated accounting documents of branches of the Centre for the treatment of acute poisoning. The aggregation of the material used numerical characteristics of the variables with the assessment of their accuracy and reliability, the significance of differences increased non-parametric Pearson criterion.

Results. The prevalence in biological fluids in hospitalized patients of γ-hydroxybutyrate was 46.6% (1452), synthetic α-PVP - 20,2% (631), synthetic opioids (methadone) and 13.2% (413). In the overall structure of acute poisonings registered in 2019, the proportion of poisoning with modern drugs amounted to 22.2% (4442), the case-fatality rate is 0.3%, which proves its high epidemiological significance. In the course of studying the dynamic characteristics of the epidemiological process the main peaks of the detection of psychoactive substances among the total number of performed laboratory research were established to be noted in July (52%), August (60,8%) and November (54,3%) 2019 based on the analysis conclusions are made about the feasibility of improving the system of prevention of acute poisonings with modern psychoactive substances at the pre-hospital and hospital stages.

Hygiene and Sanitation. 2020;99(6):569-574
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OCCUPATIONAL HEALTH

Changes in working conditions and character of occupational pathology in enterprise workers in the Arctic

Gorbanev S., Syurin S.

Resumo

Introduction. Labor in the Arctic is associated with an increased risk of developing occupational diseases.

The purpose of the study was to identify changes in risk factors, structure, and prevalence of occupational pathology among employees of enterprises in the Arctic during 2007-2018.

Material and methods. The analysis of the data of socio-hygienic monitoring “Working conditions and occupational morbidity” of the Russian Arctic zone population was carried out.

Results. 72.6% of workers at enterprises in the Arctic were found to have contact with harmful occupational factors. Within 12 years, the proportion of individuals exposed to noise and chemical factors decreased (p <0.001), while the proportion of those exposed to whole-body vibration, fibrogenic aerosols, and having increased severity of labor increased (p<0.001). In 2007-2018, the number of occupational pathology cases among employees of mining enterprises increased significantly (from 38.8% to 62.8%, p <0.001), while in metallurgical plants-it decreased (from 33.2% to 7.3% (p <0.001). In the structure of occupational pathology, the shares of radiculopathy (p <0.001) and vibration disease (p <0.001) increased due to a decrease in the shares of chronic bronchitis (p <0.001) and mono-polyneuropathy (p <0.001). Also, characteristic features of occupational pathology were an increase in the number of diseases associated with the severity of labor (from 20.7% to 46.9%, p <0.001), diseases diagnosed in one employee (from 1.006 ± 0.004 to 1.396 ± 0.030 cases, p < 0.001) and the number of men among occupational patients (from 87.3% to 94.7%, p <0.001).

Conclusion. It is necessary to continue both improve working conditions at enterprises in the Arctic, and study the reasons for the low efficiency of prevention of occupational diseases, caused primarily by increased severity of labor in the mining industry.

Hygiene and Sanitation. 2020;99(6):575-580
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Clinical and hygienic evaluation of patients with occupational polyneuropathy of upper extremities

Greben’Kov S., Mal’Kova N., Milutka E., Kochetova O.

Resumo

Introduction. The article presents the results of a study of working conditions and the health status of patients with occupational polyneuropathy (PNP) of the upper limbs. Such a clinical and hygienic assessment of people with occupational PNP contributes to the optimal examination and treatment of patients with the preliminary diagnosis who are referred to occupational pathology centers.

Material and methods. The study included 236 patients of two main occupations (painters-plasterers and miners): 113 women and 123 men.

Results. The average age of patients at the time of the examination was: for painters-plasterers (women) - 55.5 ± 5.7 years, for miners (men) - 53.9 ± 6.3 years. Work experience of patients with physical overload at the time of diagnosis of occupational PNP accounted for plasterers - 25.1 ± 8.0 years, for miners - 20.4 ± 6.7 years. Working conditions of plasterers and miners were revealed to contribute to the development of occupational diseases of the peripheral nervous system and musculoskeletal system from the effects of physical overload and functional overstrain of the muscles of the upper extremities. Most often occupational PNP of the upper limbs is accompanied by the parallel development of professional chronic shoulder-scapular periarthrosis, epicondylosis, myofibrosis of the forearms, and shoulder girdle (a complex of occupational pathology of the «working hand»); radiculopathy of the cervical and lumbosacral levels.

Conclusions. The main common harmful factor in the examined patients is the severity of the labor process. In less than one-fourth of the examined patients (15,7%) occupational PNP of the upper limbs was the only occupational disease. In other cases, its development was accompanied by the appearance of other occupational diseases of the peripheral nervous system and the musculoskeletal system. Patients referred to the examination in occupational pathology centers with a diagnosis of “PNP of the upper extremities” need a comprehensive examination to verify a possible complex of occupational pathology.

Hygiene and Sanitation. 2020;99(6):581-585
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Assessment of operational conditions of dentists working in state children’s dental polyclinics

Karelin A., Ionov P., Yeremin G.

Resumo

Introduction. Assessing the operational conditions of doctors is a difficult and urgent task. There are very few studies on the operational conditions of dentists providing care to children.

The aim of the study was to conduct a comprehensive hygienic assessment of the operational dentists working in state children’s dental polyclinics.

Material and methods. A comprehensive hygienic assessment of the operational conditions of dentists providing care to children was performed at 49 workplaces in 5 state medical institutions in St. Petersburg. We studied the factors of the operational environment (physical, chemical, biological), as well as the factors of the labor process (severity and hardness), and performed the comparison of the operational conditions of pediatric dentists, dental surgeons, and orthodontists. The paired t-test or Mann-Whitney was used for comparison of means. All tests were two-way; the level of statistical significance p <0.05.

Results. According to the microclimate parameters, vibration, and lighting, all workplaces corresponded to the second (permissible) class of working conditions. In terms of noise, the working conditions of pediatric dentists and orthodontic corresponded to class 3.3, and the working conditions of dental surgeons - to class 2. The degree of chemical pollution at all workplaces corresponded to class 2, the degree of biological air pollution - to class 3.2. According to the hardness of the labor process, the working conditions of dentists of specialties under investigation corresponded to class 2 at 36 workplaces (73%) and class 3.1 at 13 workplaces (27%). In terms of labor intensity, they corresponded to class 1 at 20 workplaces (41%) and class 2 at 29 workplaces (59%). The overall assessment of operational conditions for pediatric dentists and orthodontists corresponds to class 3.3, and for dental surgeons – to class 3.2.

Conclusion. The major harmful factors at the workplace of dentists were noise, biological pollution, and the hardness of the work process. It is necessary to further study the comprehensive and combined effects of various occupational factors of dentists taking care of children to maintain health, working capacity, and high-level quality of life, as well as to develop measures for their improvement.

Hygiene and Sanitation. 2020;99(6):586-590
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Occupational health and functional condition of the organ of vision in employees at the modern production of microelectronics

Mal’Kova N., Petrova M., Kiryanova M.

Resumo

Introduction. In the emerging digital economy, microelectronics is a driver of civilizational progress, ensuring technological sovereignty, and determines the level of development of modern society. Its elemental base is continuously developing and improving in the direction of microminiaturization of electronic components and complex miniaturization of equipment. In this regard, the purpose of the study was a hygienic assessment of operational conditions and the functional state of the visual analyzer in employees working in the modern production of microchips and semiconductor devices.

Material and methods. At the workplaces of the radio components collectors there were measured sound levels, artificial lighting, and microclimate parameters; air pollution by chemicals; the hardness and intensity of work are estimated based on timing observations. The functional state of the organ of vision was studied once and in the dynamics of the working day. The operation of the accommodation apparatus, as well as the state of the receptor link on the thresholds of color perception, were studied.

Results. Levels of chemical and physical factors of the operational environment during assembly, sealing, and labeling operations were revealed not to be over normalized values. According to the results of timing observations, the time of use of optical instruments is from 55 to 75% of the shift, which characterizes the work process as stressful as grade 3 (harmful) 1st and 2nd degree, according to the duration of being in a fixed sitting position for more than 50% of the time, the severity of labor is estimated as grade 3 1st degree. The obtained data indicate a decrease in the volume of accommodation of the eye and an increase in color discrimination thresholds in the dynamics of the working day.

Discussion. In shaping the operational conditions of workers who assemble and control products, the decisive role belongs to the hardness and intensity of the labor process, in particular, to the long-term restriction of motor activity in a fixed sitting position and the visual load associated with performing precision work using optical instruments. A change in the function of vision, characterized by a violation of the accommodative ability of the eye, a decrease in color perception, indicates the development of visual fatigue in collectors.

Conclusion. Despite the modernization of production equipment, a significant proportion of labor operations for the assembly of products are carried out manually. Given the impossibility of ensuring complete automation of technological processes at the enterprises, preventive measures should be aimed at organizing a rational mode of operation that provides relief of vision.

Hygiene and Sanitation. 2020;99(6):591-596
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Typical drawbacks in sanitary and hygienic characteristics of labor conditions submitted for the examination of the relation of diseases with an occupation in medical workers

Petrukhin N.

Resumo

Introduction. This article presents typical drawbacks in the sanitary-hygienic characteristics of working conditions, aimed at examining the relationship of the disease with the occupation among medical workers for the period 2000-2017 in the North-West Federal District, and making it difficult to conduct this examination with a positive outcome for the patient. Ways to eliminate these drawbacks are proposed.

The purpose of the study is to establish the main typical drawbacks of the operational conditions there when compiling the sanitary-hygienic characteristics and hindering the establishment of a causal relationship between the disease and the occupation in medical workers when resolving expert issues, suggest ways to address them.

Material and methods. Based on the materials of the Federal State Budgetary Institution Scientific Center for Hygiene and Public Health and the Centers for Occupational Pathology (COP) of the subjects of the Northwestern Federal District of the Russian Federation (NWFD), a retrospective analysis of a sample of case histories of patients with established occupational diseases (n = 227) and unidentified cases (n = 32) employed in medical institutions of the North-Western Federal District and sent to the COP to examine the relationship between the disease and the occupation. Between 2000 and 2017 259 medical workers were sent to the central control center on the territory of the NWFD for the examination of the relationship between the disease and the occupation, 32 were not found to have a causal relationship with the occupational activity.

Results. The analysis of sanitary and hygienic characteristics indicates an insufficient objective assessment of the operational conditions of medical workers. In most cases, the compilers of these characteristics did not critically transfer data from the documentation for a special assessment of operational conditions into them and did not take into account the leading role of the biological factor in shaping the risk of occupational pathology.

Conclusion. To correct the situation, serious optimization of both the regulatory framework and the working methods of the Federal Service for Oversight of Consumer Protection and Welfare institutions, as well as other structures involved in assessing working conditions in healthcare institutions, is required.

Hygiene and Sanitation. 2020;99(6):597-602
pages 597-602 views

HYGIENE OF CHILDREN AND ADOLESCENTS

Hygienic characteristics of the functional state of the cardiorespiratory system of children exposed to combined effects of air pollution in different climatic conditions

Levanchuk A., Kopytenkova O.

Resumo

Introduction. Economic activity without taking into account the ecological potential of the territory, the possibilities of self-purification of the natural environment, as well as the adaptive capabilities of the population has led to irreversible changes in many territories. This reduces the level of health of the population and hinders the socio-economic development of the regions.

Material and methods. The research was conducted in seven cities located in four climatic zones with varying degrees of air pollution. To assess the level of atmospheric air pollution, the P-Pinigin index was used, and the WBGT index was used for meteorological factors. Data on a medico-biological and social nature were obtained through a questionnaire survey of parents (2380 children). The incidence rates were studied based on the materials of primary accounting documents of forms F. 112-u and F. 026-u (2400 children). In 506 children, indices of the functional state of the cardiorespiratory system, the function of the respiratory system, as well as the functional state of children before and after dosed physical activity were studied.

Results. The study revealed more numerous groups of frequently and long-term ill children, children with lower indices of respiratory function, and adverse responses to the dosed physical activity. A more adverse effect of the combined effects of harsh climatic conditions and high levels of atmospheric pollution on the studied indices of children’s health was found.

Conclusion. The results obtained should be taken into account when organizing medical services and ensuring the sanitary and epidemiological well-being of the population living in the industrial cities of the Northern regions.

Hygiene and Sanitation. 2020;99(6):603-609
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Screening and post-screening of air pollution markers in mixed saliva of preschool children

Khripach L., Knyazeva T., Zheleznyak E., Makovetskaya A., Koganova Z., Budarina O., Sabirova Z., Ingel F., Demina N., Lebedeva N.

Resumo

Introduction. salivary diagnostics is a promising area that requires further research.

The aim of the study. The two-stage study is aimed at identifying reliable biochemical and immunological markers of the influence of atmospheric air pollution in saliva samples in preschool children.

Material and methods. Mixed saliva samples were taken from 112 children aged 5-7 years in 6 kindergartens located at distances of 1.7-5.9 km from the complex of agricultural processing enterprises. At the screening stage, the intensity of luminol-dependent chemiluminescence (LC), levels of secretory IgA (sIgA), IL-8, uric acid, activities of α-amylase, and lysosomal enzyme N-acetyl-β-d-glucosaminidase (NAG) were determined in saliva samples; at the post-screening stage, IL-1b and IL-6 were added.

Results. In children at the screening stage only those markers that can be considered as indirect signs of phagocyte activation were associated with exposure levels to industrial zone emissions by significant equations: CL (y=6.98-0.17 x; p=7.2*10-9); IL-8 (y=776.2-83.2 x; p=3*10-4); NAG (y=13.94-0.93 x; p=0.037). To check whether this coincidence is random, we selected two additional markers in the form of functional “fork”: IL-1β (leukocyte pyrogen) and IL-6 (cofactor of B-lymphocyte differentiation). Methods of regression, correlation, and cluster analysis confirmed all 4 “phagocytic” markers significantly to increase along the gradient of industrial emissions and form a single cluster, cross-linked with significant correlation coefficients. IL-6 saliva content was associated with exposure levels by a rise-fall relationship, and, contrary to conventional beliefs, had no connection with sIgA content. The last finding may be related to the lack of ability of IL-6 and defensins to induce sIgA in mice [Boyaka et al., 2001].

Conclusion. The survey results suppose that emission gradient from the industrial zone contains PM and does not contain haptens or immunotoxic compounds. Post-screening can be a useful technique when using saliva samples as insufficiently studied objects.

Hygiene and Sanitation. 2020;99(6):610-617
pages 610-617 views

HEALTH RISK ASSESSMENT

Dynamics of indices of the workers’ health in different labor intensity

Sorokin G., Shilov V.

Resumo

Introduction. Work and stress occupy a leading place among the causes of diseases of Russians. Working hours and work intensity (WI) are the main parameters of the workload. The main difficulty of physiological analysis, measurement, and hygienic assessment of WI is a purely individual psychophysiological characteristic of the degree of stress of the working person’s body, being masked by three factors: the composition and organization of labor actions, personal factor, and hygienic working conditions. The individual physiological range of average work intensity (IR) is 1.5. The change in WI inside of this diapason determines the intra-shift dynamics of performance, from the typical monotonous activity to the characteristic of neuro-humoral stress. The criterion for physiological and hygienic assessment of Wt is the stability of the dynamics of performance, fatigue, and health indices of employees.

The purpose of the study: to establish the annual increase in the risk of health disorders of employees at different levels of physiological intensity of work, correlated with IR.

Materials and methods. We studied WI and the dynamics of health index s(DZ) in 2509 physical and mental workers with varying degrees of fatigue (industrial workers, doctors, nurses, school teachers, office workers). The annual increase in risk (AIR) chronic fatigue syndrome, cardiovascular diseases, and diseases of the musculoskeletal system, long-term morbidity with the temporary disability (MTD) was used to characterize the WI.

Results. With high and high WI, the long-MTD AIR (0.80%) of the watch factory workers is 3.2 times higher than the control level - 0.25%. At a high WI level (1.11-1.20) of the installers, the AIR of cardiovascular diseases with MTD (1.0%) is 6.7 times higher than the control level of 0.15%, and the GPR of musculoskeletal diseases (1.1%) is 7.9 times higher than the control level of 0.14%. In precision workers with increased WI (1.01-1.10), the AIR of chronic fatigue syndrome (1.98%) exceeds the background level of 0.5% per year by 3.9 times, and with a high WI level (1.11-1.20), the AIR of musculoskeletal disorders exceeds the control level (0.2%) by 10.7 times. The maximum WI values for mental workers are 5-14% higher than those set for manual labor.

Conclusions. 1. The IR is determined by the ratio of the maximum labor productivity, at which there is still no employee fatigue at the end of the working day, to the productivity, at which there is large employee fatigue. IR = 1.5. 2. When WI is 20 -30% above the lower bound of IR, there are 2-4 times increased AIR health disorders; while WI 30-40% higher than the lower border of IR, AIR for chronic fatigue syndrome, cardiovascular disease, diseases of the musculoskeletal system increases by 5-10 times. 3. Long hours, which are often considered the main risk factor for the health of workers, are the actual risk factor if the work is not performed at a reduced intensity.

Hygiene and Sanitation. 2020;99(6):618-623
pages 618-623 views

Legal analysis of the use of health risk assessment in the field of sanitary and epidemiological well-being of the population

Karelin A., Lomtev A., Yeremin G., Mozzhukhina N., Ganichev P.

Resumo

In recent years, when regulating relations in the field of ensuring the sanitary and epidemiological well-being of the population, risk-oriented supervision, and the population health risk assessment have been increasingly applied. The usage of these effective tools requires a clear legal framework. The article represents the analysis of the legal aspects of the usage of public health risk assessment and risk-based control (surveillance) in the field of the sanitary-epidemiological well-being of the population in the Russian Federation. Special attention is drawn to the problems of applying the methods for state sanitary-epidemiological surveillance. The analysis of draft laws related to this area and the legislation and experience of other countries is performed. The analysis of modern legislative changes regarding the application of risk-based supervision and the application of public health risk assessment allows concluding that the methodology for health risk assessment is an important tool in regulating relations in the field of ensuring the sanitary and epidemiological well-being of the population. Currently, there is a certain legal and regulatory framework for its use. But it needs improvement. As the experience of the “regulatory guillotine” carried out in many countries shows, this procedure allows eliminating many contradictions existing in regulatory legal acts. A risk-based approach is enshrined in the legislation of all EAEU member countries. At the same time, an analysis of the regulatory framework showed that a risk-oriented model was formed to a greater extent and is functioning in terms of classification (categorization) by the risk of harm to the health of legal entities (LE), individual entrepreneurs (IP) or their activities than risk-based supervision of products traded in the consumer market. The transition to a new model of state control (supervision) requires legal consolidation of the risk management system in the law on sanitary and epidemiological well-being and taking into account the experience of the EU and EAEU countries in this area.
Hygiene and Sanitation. 2020;99(6):624-630
pages 624-630 views

POPULATION HEALTH

Assessment of anxiety and postural balance in strategy for health care for elderly women

Gudkov A., Chashchin V., Dyomin A., Popova O., Frolova N.

Resumo

Introduction. The relevance of the study is determined by the tasks set in the National Project “Demography” (Federal Project “Senior Generation”), and consists in the need for registration of functional characteristics of the organism of older age groups in the accounting system of measures to preserve their health.

Aim of the study is to establish the characteristics of anxiety and components of the postural balance (CPB) in elderly women with the risk of recurrent falls.

Material and methods. We examined 232 women aged 55-69 years who reported that they experienced two or more falls over the past 12 months. The first age group included women whose calendar age was in the range of 55-64 years (n = 72), the second - women aged 65-69 years (n = 160). Using the self-assessment diagnostic technique by Spielberger, Ch. D., and Khanin, Yu. L. we determined the level of situational (SA) and personal (PA) anxiety. To assess the features of the CPB, a US-manufactured computerized dynamic posturography complex Smart Equitest Balance Manager was used. Sensory Organization Test (SOT) and Motor Control Test (MCT) tests were conducted.

Results. When analyzing anxiety scale values, a high level of PA was revealed in both groups of women, however, the SA indices in women 55-64 years old were lower than for women 65-69 years old (p = 0.005). All this indicates that the development of recurrent falls among women older 64 years will be accompanied by mental tension and pronounced emotional responses to postural changes. According to computerized dynamic posturography testing, age-related differences in CPB have been revealed. There was a decrease in the quality of the equilibrium function by test 5 SOT and vestibular information in postural control found in women of age group 55-64, whereas for women in the age group 65-69 there was a decrease in the quality of equilibrium function by test 4 and visual information in balance control. In the latter, there was also found an increase in the time of coordinated motor response by the test of unexpected external impact on the shift of the center of gravity capable of enhancing the risks of stuttering and falls when walking fast.

Conclusion. The suggested criteria for assessing the risk of falls in elderly women can be used to develop individual health programs to prevent serious consequences in such events.

Hygiene and Sanitation. 2020;99(6):631-637
pages 631-637 views

METHODS OF HYGIENIC AND EXPERIMENTAL INVESTIGATIONS

Hygienic assessment of chemical composition of pollutants generated in various ways of consumption nicotine-containing product

Zaritskaya E., Yakubova I., Mikheeva A., Alikbaeva L.

Resumo

Introduction. Lack of studies proving or denying passive smoker health risks caused by electronic cigarettes prevented from introducing restrictive measures and considering them to be tobacco products as early as in 2013. Indoor air pollution by consumed nicotine-containing products in extra-low concentrations which could be detected using high-tech lab mass-spectrometry techniques was the object of study.

Material and methods. “Unknown composition” air sampling was carried out in the process of simulation tests. Three types of tobacco products were used in the tests: tobacco cigarettes, electronic nicotine-delivery system (ENDS), battery-powered heat-not-burn tobacco cigarettes (IQOS) with tobacco sticks. “Unknown composition” air samples were analyzed for volatile organic compounds, medium volatile organic compounds, polycyclic aromatic hydrocarbons (total and separately 16 priority PAHs, inorganic elements (Si, Pb, Cu, Cr, Ni). Sampling was carried out three times a day on separate days for each type of product and control, a total of 12 “unknown composition” air samples being collected. The study of “unknown composition” air samples was carried out at the accredited chemical-analytical center “Arbitrazh” of the D.I. Mendeleev Institute of Metrology (accreditation certificate РОСС RU.0001.510650).

Results. A total number of 115 chemicals were determined, and among them, substances significant concentrations of which are most likely related to tobacco or nicotine consumption, as compared to control, and depend on the type of nicotine-containing product, were identified. Statistically significant concentration excess (р≤ 0.05), as compared to control, was seen for 27 chemicals in indoor air polluted by-products of consumed tobacco cigarettes; when using electronic nicotine-delivery system (ENDS) the excess (р≤ 0.05) was shown for 2 chemicals, i.e.: acenaphthylene and benz(a)perene, and when using heat-not-burn tobacco products (IQOS) the excess of studied chemical concentrations in comparison with control was not reported.

Conclusion. Findings of comparative analysis of “unknown composition” air sampling give evidence that a much larger number of harmful chemicals at significantly exceeded concentrations (р≤ 0.05), including those causing human health risks, is released when smoking cigarettes, as compared to using ENDS or IQOS.

Hygiene and Sanitation. 2020;99(6):638-644
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The standard deviation of the red blood cells distribution width by volume as an assumed biomarker of chronic alcohol intoxication

Shilov V., Vershinin A., Guseinov G., Lukin V., Markova O.

Resumo

Introduction. At present, Russia occupies one of the leading places in the world in ethanol consumption per capita. The actual and unsolved problem remains the diagnosis and prevention of chronic alcoholism. The definition of carbohydrate-deficient transferrin proposed by many authors has many drawbacks, in particular, a rather high cost, as well as a limited sensitivity of the index after two weeks from an episode of ethanol consumption. For this reason, it seems necessary to search for alternative biomarkers of chronic alcoholism. One of the applicants for the role of a marker of chronic alcohol intoxication is the Red blood cell Distribution Width - standard deviation (RDW-SD). The article contains the results of a study of changes in the standard deviation of the RDW-SD in the venous blood of patients with acute ethanol poisoning in cases with chronic alcohol intoxication.

The aim of this work was to quantify the change in RDW-SD in patients with alcohol dependence (chronic alcohol intoxication) during periods of exacerbation (acute alcohol poisoning of moderate severity).

Material and methods. The research materials were clinical blood tests of 245 patients on the first day after admission to the Department of Toxicology of the I.I. Dzanelidze. Research Institute of Emergency Medicine.

Results. From the literature, it is known that the RDW-SD is largely associated with folic acid deficiency. Vitamin B9 deficiency can significantly increase the risk of cardiovascular disease due to the development of hyperhomocysteinemia in patients. Particular attention is required for patients aged 46-65 years, who have the highest level of RDW-SD with an increased risk of developing cardiovascular events. At the same time, the highest mortality rate in this age group from the reasons associated with the use of ethanol is noted, which gives reason to consider RDW-SD as one of the possible indices of the mortality risk.

Conclusion. The possibility of using the magnitude of the change in the RDW-SD index as a biomarker of chronic alcohol intoxication in patients with a certain risk of cardiovascular complications is discussed with the rationale for the appointment of folic acid preparations as part of the complex treatment of chronic alcohol intoxication.

Hygiene and Sanitation. 2020;99(6):645-648
pages 645-648 views