The effect of rehabilitation measures on the severity of endotoxicosis and its relationship with changes in hemorheology in acute poisoning

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Abstract

Introduction. The use of multidimensional statistical analysis methods (factorial and cluster methods) to study the pathogenesis and sanogenesis of acute poisoning (AP) with psychopharmacological agents (pPPhA), neurotoxicants (pNT) and corrosive substances (pCS) did not allow us to judge the presence of a direct connection between the hemorhealogy system (HR). We received a positive answer to this question earlier with the help of pair correlation analysis (PCA).

New data on the sanogenetic effect of the applied methods of rehabilitation treatment in terms of changes in the indicators of HR and endotoxicosis (ET) and the relationship between them are also interesting.

The purpose of the work is to assess the initial state of the indicators of HR and ET and the effect on them of a combination of medicinal and non–medicinal products used as part of rehabilitation measures for AP.

Material and methods. Paired correlation analysis of the block structure of the obtained correlation matrices was applied to 52 patients with severe pPPhA, pNT and pCS. This analysis established the relationship between two indicators – both before the start of rehabilitation measures (the use of ethylmethylhydroxypyridine succinate, laser hemotherapy, hyperbaric oxygenation and mesodiencephalic modulation in accordance with the type of AP), and after their completion, before the discharge of patients from the hospital.

Results. Statistically significant correlations were established between the indicators of HR and ET both before the start of treatment (0.44–0.94, without sign) and after its completion (0.49–0.99, without sign), which allowed us to confirm at a higher level a direct link between the development of HR and ET disorders, as well as to draw a conclusion about the sanogenetic effect of rehabilitation treatment.

Limitations. The study has no limitations for further use of this methodological approach.

Conclusion. The obtained data can serve as a justification for the introduction into practice of the proposed methods of mathematical analysis of the results of treatment measures.

Compliance with ethical standards. The study does not require the submission of the conclusion of the biomedical ethics committee or other documents.

Authors’ contribution:
Goldfarb Yu.S. – concept and design of the study, interpretation of the results of the study, writing, editing;
Elkov A.N. – statistical processing, interpretation of the results of the study;
Badalyan A.V. – examination of patients within the framework of the study design, participation in writing and editing;
Potshveria M.M. – participation in the interpretation of the data obtained, editing;
Bitkova E.E. – performing the laboratory part of the study within the framework of the study design, processing and interpretation of laboratory data.
All co-authors – approval of the final version of the article, responsibility for the integrity of all parts of the article.

Conflict of interest. The authors declare no conflict of interest.

Funding. The study had no sponsorship.

Accepted: June 5, 2024 / Received: July 10, 2024 / Published: August 30, 2024

 

About the authors

Yuri S. Goldfarb

State Budgetary Healthcare Institution of the city of Moscow “N.V. Sklifosovsky Scientific Research Institute of Emergency Medicine of the Moscow Health Department”; Federal State Budgetary Educational Institution of Additional Professional Education “Russian Medical Academy of Continuing Professional Education” of the Ministry of Health of the Russian Federation

Author for correspondence.
Email: GoldfarbJS@sklif.mos.ru
ORCID iD: 0000-0002-0485-2353

Doctor of Medical Sciences, Professor, Head of the Department of External Scientific Relations, Researcher at the Department of Acute Poisoning and Somatopsychiatric Disorders of the State Budgetary Healthcare Institution of the city of Moscow “N.V. Sklifosovsky Scientific Research Institute of Emergency Medicine of the Moscow Health Department”, 129090, Moscow, Russian Federation; Honorary Head of the Department, Professor of the Department of Clinical Toxicology of the Federal State Budgetary Educational Institution of Additional Professional Education “Russian Medical Academy of Continuing Professional Education” of the Ministry of Health of the Russian Federation, 125993, Moscow, Russian Federation

e-mail: GoldfarbJS@sklif.mos.ru

Russian Federation

Alexander N. Yelkov

State Budgetary Healthcare Institution of the city of Moscow “N.V. Sklifosovsky Scientific Research Institute of Emergency Medicine of the Moscow Health Department”; Federal State Budgetary Educational Institution of Additional Professional Education “Russian Medical Academy of Continuing Professional Education” of the Ministry of Health of the Russian Federation

Email: ElkovAN@sklif.mos.ru
ORCID iD: 0000-0002-5945-503X

Candidate of Physical and Mathematical Sciences, Senior Researcher at the Department of Treatment of Acute Poisoning and Somatopsychiatric Disorders of the State Budgetary Healthcare Institution of the city of Moscow “N.V. Sklifosovsky Scientific Research Institute of Emergency Medicine of the Moscow Health Department”, 129090, Moscow, Russian Federation; employee of the Department of Clinical Toxicology of the Federal State Budgetary Educational Institution of Additional Professional Education “Russian Medical Academy of Continuing Professional Education” of the Ministry of Health of the Russian Federation, 125993, Moscow, Russian Federation

e-mail: ElkovAN@sklif.mos.ru

Russian Federation

Amayak V. Badalyan

State Budgetary Healthcare Institution of the city of Moscow “N.V. Sklifosovsky Scientific Research Institute of Emergency Medicine of the Moscow Health Department”; Federal State Budgetary Educational Institution of Additional Professional Education “Russian Medical Academy of Continuing Professional Education” of the Ministry of Health of the Russian Federation

Email: BadalianAV@sklif.mos.ru
ORCID iD: 0000-0003-4429-2503

Doctor of Medical Sciences, Head of the Department of Acute Poisoning Treatment of the State Budgetary Healthcare Institution of the city of Moscow “N.V. Sklifosovsky Scientific Research Institute of Emergency Medicine of the Moscow Health Department”, 129090, Moscow, Russian Federation; Associate Professor of the Department of Clinical Toxicology of the Federal State Budgetary Educational Institution of Additional Professional Education “Russian Medical Academy of Continuing Professional Education” of the Ministry of Health of the Russian Federation, 125993, Moscow, Russian Federation

e-mail: BadalianAV@sklif.mos.ru

Russian Federation

Mikhail M. Potshveria

State Budgetary Healthcare Institution of the city of Moscow “N.V. Sklifosovsky Scientific Research Institute of Emergency Medicine of the Moscow Health Department”; Federal State Budgetary Educational Institution of Additional Professional Education “Russian Medical Academy of Continuing Professional Education” of the Ministry of Health of the Russian Federation

Email: PotskhveriyaMM@sklif.mos.ru
ORCID iD: 0000-0003-0117-8663

Doctor of Medical Sciences, Head of the Scientific Department of Acute Poisoning and Somatopsychiatric Disorders of the State Budgetary Healthcare Institution of the city of Moscow “N.V. Sklifosovsky Scientific Research Institute of Emergency Medicine of the Moscow Health Department”, 129090, Moscow, Russian Federation; Professor of the Department of Clinical Toxicology of the Federal State Budgetary Educational Institution of Additional Professional Education “Russian Medical Academy of Continuing Professional Education” of the Ministry of Health of the Russian Federation, 125993, Moscow, Russian Federation

e-mail: PotskhveriyaMM@sklif.mos.r

Russian Federation

Elena E. Bitkova

State Budgetary Healthcare Institution of the city of Moscow “N.V. Sklifosovsky Scientific Research Institute of Emergency Medicine of the Moscow Health Department”

Email: BitkovaEE@sklif.mos.ru
ORCID iD: 0000-0001-6066-830X

Candidate of Medical Sciences, Senior Researcher at the Department of Biotechnology and Transfusiology of the State Budgetary Healthcare Institution of the city of Moscow “N.V. Sklifosovsky Scientific Research Institute of Emergency Medicine of the Moscow Health Department”, 129090, Moscow, Russian Federation

e-mail: BitkovaEE@sklif.mos.ru

Russian Federation

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Copyright (c) 2024 Goldfarb Y.S., Yelkov A.N., Badalyan A.V., Potshveria M.M., Bitkova E.E.


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