Email this article INFLUENCE OF POTASSIUM BICHROMATE ON BIOCHEMICAL AND IMMUNOLOGICAL CHARACTERISTICS OF WISTAR RATS ORGANISM
- Authors: Mikhaylova I.V.1, Smolyagin A.I.1, Kraskov S.I.1, Ermolina E.V.1, Boev V.M.1
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Affiliations:
- SBEI «Orenburg State Medical University», Ministry of Health of Russia
- Issue: No 3 (2015)
- Pages: 21-25
- Section: Articles
- Published: 12.06.2015
- URL: https://rjsocmed.com/0869-7922/article/view/641311
- DOI: https://doi.org/10.15690/vramn455
- ID: 641311
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Abstract
The impact of potassium dichromate on immunological and biochemical parameters in Wistar rats was investigated in a model experiment . In the first place it was found out that a lasting uptake of chromium by the Wistar rat organism produces a depressive influence on the spleen quantitative and functional characteristics in laboratory animals; secondly, it was established that revealed shifts in the immune system parameters are caused by an increased intensity of free radical oxidation (FRO) in rats ( blood serum, spleen, liver) and lipid peroxidation (LPO), shown in an increasing concentration of conjugated dienes (CD) and malon dialdehyde (MDA) in spleen and liver against the background of the catalase decreased activity and superoxide dismutase (SOD) -erythrocytes in rats; and third, revealed mechanisms accounting for changes in immunological indicators present an experimental validation to elaborate approaches to preventing adverse effects of that xenobiotic .
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About the authors
Irina Valer’evna Mikhaylova
SBEI «Orenburg State Medical University», Ministry of Health of Russia
Author for correspondence.
Email: noemail@neicon.ru
Доктор биологических наук, доцент кафедры химии и фармацевтической химии Оренбургского государственного медицинского университета Минздрава РФ, 460000, г. Оренбург, Российская Федерация
e-mail: michaylova74@yandex.ru
Russian FederationAleksandr Ivanovich Smolyagin
SBEI «Orenburg State Medical University», Ministry of Health of Russia
Email: noemail@neicon.ru
Доктор медицинских наук, профессор, заведующий проблемной лабораторией по изучению механизмов естественного иммунитета Оренбургского государственного медицинского университета Минздрава РФ, 460000, г. Оренбург, Российская Федерация
e-mail: probllab.orenburg@mail.ru
Russian FederationSergey Ivanovich Kraskov
SBEI «Orenburg State Medical University», Ministry of Health of Russia
Email: noemail@neicon.ru
Доктор медицинских наук, профессор, заведующий кафедрой химии и фармацевтической химии Оренбургского государственного медицинского университета Минздрава РФ, 460000, г. Оренбург, Российская Федерация
e-mail: ks_oren@mail.ru
Russian FederationEvgenija Vjacheslavovna Ermolina
SBEI «Orenburg State Medical University», Ministry of Health of Russia
Email: noemail@neicon.ru
Кандидат биологических наук, старший научный сотрудник проблемной лаборатории по изучению механизмов естественного иммунитета Оренбургского государственного медицинского университета Минздрава РФ, 460000, г. Оренбург, Российская Федерация
e-mail: probllab.orenburg@mail.ru
Russian FederationViktor Mihajlovich Boev
SBEI «Orenburg State Medical University», Ministry of Health of Russia
Email: noemail@neicon.ru
Доктор медицинских наук, профессор, ректор Оренбургского государственного медицинского университета Минздрава РФ, 460000, г. Оренбург, Российская Федерация
e-mail: probllab.orenburg@mail.ru
Russian FederationReferences
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