电邮这篇文章 INFLUENCE OF POTASSIUM BICHROMATE ON BIOCHEMICAL AND IMMUNOLOGICAL CHARACTERISTICS OF WISTAR RATS ORGANISM
- 作者: Mikhaylova I.V.1, Smolyagin A.I.1, Kraskov S.I.1, Ermolina E.V.1, Boev V.M.1
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隶属关系:
- SBEI «Orenburg State Medical University», Ministry of Health of Russia
- 期: 编号 3 (2015)
- 页面: 21-25
- 栏目: Articles
- ##submission.datePublished##: 12.06.2015
- URL: https://rjsocmed.com/0869-7922/article/view/641311
- DOI: https://doi.org/10.15690/vramn455
- ID: 641311
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The impact of potassium dichromate on immunological and biochemical parameters in Wistar rats was investigated in a model experiment . In the first place it was found out that a lasting uptake of chromium by the Wistar rat organism produces a depressive influence on the spleen quantitative and functional characteristics in laboratory animals; secondly, it was established that revealed shifts in the immune system parameters are caused by an increased intensity of free radical oxidation (FRO) in rats ( blood serum, spleen, liver) and lipid peroxidation (LPO), shown in an increasing concentration of conjugated dienes (CD) and malon dialdehyde (MDA) in spleen and liver against the background of the catalase decreased activity and superoxide dismutase (SOD) -erythrocytes in rats; and third, revealed mechanisms accounting for changes in immunological indicators present an experimental validation to elaborate approaches to preventing adverse effects of that xenobiotic .
作者简介
Irina Mikhaylova
SBEI «Orenburg State Medical University», Ministry of Health of Russia
编辑信件的主要联系方式.
Email: noemail@neicon.ru
Доктор биологических наук, доцент кафедры химии и фармацевтической химии Оренбургского государственного медицинского университета Минздрава РФ, 460000, г. Оренбург, Российская Федерация
e-mail: michaylova74@yandex.ru
俄罗斯联邦Aleksandr Smolyagin
SBEI «Orenburg State Medical University», Ministry of Health of Russia
Email: noemail@neicon.ru
Доктор медицинских наук, профессор, заведующий проблемной лабораторией по изучению механизмов естественного иммунитета Оренбургского государственного медицинского университета Минздрава РФ, 460000, г. Оренбург, Российская Федерация
e-mail: probllab.orenburg@mail.ru
俄罗斯联邦Sergey Kraskov
SBEI «Orenburg State Medical University», Ministry of Health of Russia
Email: noemail@neicon.ru
Доктор медицинских наук, профессор, заведующий кафедрой химии и фармацевтической химии Оренбургского государственного медицинского университета Минздрава РФ, 460000, г. Оренбург, Российская Федерация
e-mail: ks_oren@mail.ru
俄罗斯联邦Evgenija Ermolina
SBEI «Orenburg State Medical University», Ministry of Health of Russia
Email: noemail@neicon.ru
Кандидат биологических наук, старший научный сотрудник проблемной лаборатории по изучению механизмов естественного иммунитета Оренбургского государственного медицинского университета Минздрава РФ, 460000, г. Оренбург, Российская Федерация
e-mail: probllab.orenburg@mail.ru
俄罗斯联邦Viktor Boev
SBEI «Orenburg State Medical University», Ministry of Health of Russia
Email: noemail@neicon.ru
Доктор медицинских наук, профессор, ректор Оренбургского государственного медицинского университета Минздрава РФ, 460000, г. Оренбург, Российская Федерация
e-mail: probllab.orenburg@mail.ru
俄罗斯联邦参考
- Kutsenko S.A. Bases of toxicology. St. Peterburg: Foliant; 2004 (in Russian).
- Mamyrbaev A.A. Toxicology of chromium and its compounds. Aktobe; 2012 (in Russian).
- Ermolina E.V., Mihajlova I.V. Effect of benzene and chromium on immunological parameters in Wistar rats. Vestnik OGU. 2011; 16 (135):274-6 (in Russian).
- GN 2.1.5.2280-07. Maximum permissible concentration (MPC) of chemicals in water of the economydrinking and cultural-everyday objects. Moscow: Rospotrebnadzor; 2008 (in Russian).
- Volchegorsky I.A., Dolgushin I.I., Kolesnikov O.L., Cejlikman V.Je. Experimental modeling and laboratory evaluation of the adaptive reactions. Cheljabinsk: ChGPU; 2000 (in Russian).
- Farhutdinov R.R. Free radical oxidation in biological material and chemiluminescent methods of research in experimental and clinical medicine. Ufa; 2002 (in Russian).
- Sirota T.V. A new approach to the study of adrenaline auto-oxidation process and its use for measuring the activity of superoxide dismutase. Vopr. med. Himii. 1999; 3:263 - 272 (in Russian).
- Kurlyandskiy B.A., Filov V.A., red. General Toxicology. Moscow: Meditsina; 2002 (in Russian).
- Walker L.S.K. Folate receptor 4: A new handle on regulation and memory? Immunol. and Cell. Biol. 2007; 85(7):506-7.
- Vladimirskaja E.B. Apoptosis in the regulation of cellular equilibrium and the formation of tumor growth. Voprosy gematologii, onkologii i immunopatologii v pediatrii. 2003; 7: 5-11(in Russian).
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