Email this article MATERIALS ON SUBSTANTIATION OF HYGIENIC STANDARDS FOR N-PENTYL ETHER OF CHLOROFORMIC ACID IN THE AIR OF THE WORKING AREA AND IN THE ATMOSPHERE
- Authors: Bidevkina M.V.1, Golubeva M.I.2, Pankratova G.P.1, Limantsev A.V.1, Razumnaya I.N.2, Karaev А.L.1, Potapova T.N.1
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Affiliations:
- Scientific Research Disinfectology Institute
- Joint-Stock Company All-Union Scientific Center for the Safety of Biologically Active Compounds
- Issue: No 4 (2019)
- Pages: 43-47
- Section: Articles
- Published: 28.08.2019
- URL: https://rjsocmed.com/0869-7922/article/view/641203
- DOI: https://doi.org/10.36946/0869-7922-2019-4-43-47
- ID: 641203
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Abstract
Pentyl chloroformate refers to moderately toxic substances when administered in the stomach (DL50 for white mice 1000,0 ± 86,0 mg/kg), has a pronounced irritant effect on the skin and mucous membrane of the eyes, has no skin-resorptive and sensitizing effect, weakly accumulates in the body. It shows selective irritant effect on the respiratory system on inhalation. The irritant threshold for rats is 7,8 mg/m3, for humans - 2,3 mg/m3. Hygienic standards for pentyl chloroformate are recommended for approval: MAC in the air of the working area - 0,5 mg/m3 (vapors, hazard class 2, marked «requires special protection for the skin and eyes»); tentative safe exposure level in the atmospheric air of populated areas - 0,005 mg/m3.
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About the authors
M. V. Bidevkina
Scientific Research Disinfectology Institute
Author for correspondence.
Email: bidevkinamv@niid.ru
Bidevkina Marina Vasil’evna
117246, Moscow
Russian FederationM. I. Golubeva
Joint-Stock Company All-Union Scientific Center for the Safety of Biologically Active Compounds
Email: golubevamargo@mail.ru
Golubeva Margarita Ivanovna
142450, Staraya Kupavna, Moscow region
Russian FederationG. P. Pankratova
Scientific Research Disinfectology Institute
Email: gala@onrush.ru
Pankratova Galina Pavlovna
117246, Moscow Russian FederationA. V. Limantsev
Scientific Research Disinfectology Institute
Email: av.lim@yandex.ru
Limantsev Anatoliy Vladimirovich
117246, Moscow
Russian FederationI. N. Razumnaya
Joint-Stock Company All-Union Scientific Center for the Safety of Biologically Active Compounds
Email: fake@neicon.ru
Razumnaja Irina Nikolaevna
142450, Staraya Kupavna, Moscow region
Russian FederationА. L. Karaev
Scientific Research Disinfectology Institute
Email: karayev-al@mail.ru
Karaev Andrey Lvovich
117246, Moscow
Russian FederationT. N. Potapova
Scientific Research Disinfectology Institute
Email: potapovatn@niid.ru
Potapova Tat’yana Nikolaevna
117246, Moscow
Russian FederationReferences
- Harmful substances in the environment. Oxygenated organic compounds. Part III. Ed. V.A. Filova, B.A. Ivina, Yu.I. Musiychuka. SPb .: ANO NPO Professional; 2004:237-240.(in Russian)
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- Guidelines for the establishment of approximate safe levels of exposure to harmful substances in the air of the working area. MU number 4000-85. M., USSR Ministry of Health; 1985. (in Russian)
- Requirements for the formulation of experimental studies to substantiate the maximum allowable concentrations of industrial allergens in the air of the working area and atmosphere. MU number 1.1.578-96. M.; 1996. (in Russian)
- Guidelines for the establishment of approximate safe exposure levels (TSEL) of pollutants in the atmospheric air of populated areas. MU No. 2630-82-88.M, Ministry of Health of the USSR; 1988. (in Russian)
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