Enviar artigo por via de e-mail MATERIALS ON SUBSTANTIATION OF HYGIENIC STANDARDS FOR N-PENTYL ETHER OF CHLOROFORMIC ACID IN THE AIR OF THE WORKING AREA AND IN THE ATMOSPHERE
- Autores: Bidevkina M.V.1, Golubeva M.I.2, Pankratova G.P.1, Limantsev A.V.1, Razumnaya I.N.2, Karaev А.L.1, Potapova T.N.1
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Afiliações:
- Scientific Research Disinfectology Institute
- Joint-Stock Company All-Union Scientific Center for the Safety of Biologically Active Compounds
- Edição: Nº 4 (2019)
- Páginas: 43-47
- Seção: Articles
- ##submission.datePublished##: 28.08.2019
- URL: https://rjsocmed.com/0869-7922/article/view/641203
- DOI: https://doi.org/10.36946/0869-7922-2019-4-43-47
- ID: 641203
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Resumo
Pentyl chloroformate refers to moderately toxic substances when administered in the stomach (DL50 for white mice 1000,0 ± 86,0 mg/kg), has a pronounced irritant effect on the skin and mucous membrane of the eyes, has no skin-resorptive and sensitizing effect, weakly accumulates in the body. It shows selective irritant effect on the respiratory system on inhalation. The irritant threshold for rats is 7,8 mg/m3, for humans - 2,3 mg/m3. Hygienic standards for pentyl chloroformate are recommended for approval: MAC in the air of the working area - 0,5 mg/m3 (vapors, hazard class 2, marked «requires special protection for the skin and eyes»); tentative safe exposure level in the atmospheric air of populated areas - 0,005 mg/m3.
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Sobre autores
M. Bidevkina
Scientific Research Disinfectology Institute
Autor responsável pela correspondência
Email: bidevkinamv@niid.ru
Bidevkina Marina Vasil’evna
117246, Moscow
RússiaM. Golubeva
Joint-Stock Company All-Union Scientific Center for the Safety of Biologically Active Compounds
Email: golubevamargo@mail.ru
Golubeva Margarita Ivanovna
142450, Staraya Kupavna, Moscow region
RússiaG. Pankratova
Scientific Research Disinfectology Institute
Email: gala@onrush.ru
Pankratova Galina Pavlovna
117246, Moscow RússiaA. Limantsev
Scientific Research Disinfectology Institute
Email: av.lim@yandex.ru
Limantsev Anatoliy Vladimirovich
117246, Moscow
RússiaI. Razumnaya
Joint-Stock Company All-Union Scientific Center for the Safety of Biologically Active Compounds
Email: fake@neicon.ru
Razumnaja Irina Nikolaevna
142450, Staraya Kupavna, Moscow region
RússiaА. Karaev
Scientific Research Disinfectology Institute
Email: karayev-al@mail.ru
Karaev Andrey Lvovich
117246, Moscow
RússiaT. Potapova
Scientific Research Disinfectology Institute
Email: potapovatn@niid.ru
Potapova Tat’yana Nikolaevna
117246, Moscow
RússiaBibliografia
- Harmful substances in the environment. Oxygenated organic compounds. Part III. Ed. V.A. Filova, B.A. Ivina, Yu.I. Musiychuka. SPb .: ANO NPO Professional; 2004:237-240.(in Russian)
- Guidelines for the formulation of studies on the study of irritant properties and the justification of the maximum allowable concentrations of selectively acting irritants in the air of the working area. MU number 2196-80. M., USSR Ministry of Health; 1980. (in Russian)
- Guidelines for the establishment of approximate safe levels of exposure to harmful substances in the air of the working area. MU number 4000-85. M., USSR Ministry of Health; 1985. (in Russian)
- Requirements for the formulation of experimental studies to substantiate the maximum allowable concentrations of industrial allergens in the air of the working area and atmosphere. MU number 1.1.578-96. M.; 1996. (in Russian)
- Guidelines for the establishment of approximate safe exposure levels (TSEL) of pollutants in the atmospheric air of populated areas. MU No. 2630-82-88.M, Ministry of Health of the USSR; 1988. (in Russian)
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