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Study of the Effect of Nonselective Organic Solvent Nature on the Self-Organization of Amphiphilic Block Copolymers of D,L-Lactide and Ethylene Oxide in Aqueous Solution
- Authors: Kuznetsova E.V.1, Shirokova E.M.1, Puchkova Y.A.1, Yastremsky E.V.2, Chvalun S.N.1,3
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Affiliations:
- National Research Center “Kurchatov Institute”
- Federal Research Center “Crystallography and Photonics,” Russian Academy of Sciences
- Enikolopov Institute of Synthetic Polymer Materials, Russian Academy of Sciences
- Issue: Vol 65, No 1 (2023)
- Pages: 138-152
- Section: Articles
- URL: https://rjsocmed.com/2308-1147/article/view/674813
- DOI: https://doi.org/10.31857/S2308114723700279
- EDN: https://elibrary.ru/HSGETL
- ID: 674813
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Abstract
The self-organization of biocompatible amphiphilic block copolymers of D,L-lactide and ethylene oxide with various hydrophobic poly(D,L-lactide) block length in aqueous media has been investigated. It has been shown that the nature of nonselective organic solvent has a considerable effect on the size, size polydispersity, and morphology of micelles of a block copolymer with a long poly(D,L-lactide) block. To elucidate the dependence of properties of block copolymer micelles on the common organic solvent type (acetone, tetrahydrofuran, N,N-dimethylformamide, and acetonitrile) various parameters of the used solvents have been estimated, and correlation between the Flory–Huggins coefficient and the surface tension between the hydrophobic block and the nonselective organic solvent and the parameters of micellar structures has been found.
About the authors
E. V. Kuznetsova
National Research Center “Kurchatov Institute”
Email: kuznetsova.kate992@gmail.com
123182, Moscow, Russia
E. M. Shirokova
National Research Center “Kurchatov Institute”
Email: kuznetsova.kate992@gmail.com
123182, Moscow, Russia
Yu. A. Puchkova
National Research Center “Kurchatov Institute”
Email: kuznetsova.kate992@gmail.com
123182, Moscow, Russia
E. V. Yastremsky
Federal Research Center “Crystallography and Photonics,” Russian Academy of Sciences
Email: kuznetsova.kate992@gmail.com
119333, Moscow, Russia
S. N. Chvalun
National Research Center “Kurchatov Institute”; Enikolopov Institute of Synthetic Polymer Materials, Russian Academy of Sciences
Author for correspondence.
Email: kuznetsova.kate992@gmail.com
123182, Moscow, Russia; 123182, Moscow, Russia; 117393, Moscow, Russia
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