An Insight into the Effect of Schiff Base and their d and f Block Metal Complexes on Various Cancer Cell Lines as Anticancer Agents: A Review
- Authors: Presenjit 1, Chaturvedi S.1, Singh A.2, Gautam D.1, Singh K.3, Mishra A.1
-
Affiliations:
- Radiological Nuclear and Imaging Science, Institute of Nuclear Medicine & Allied Sciences, DRDO
- Department of Zoology, Swami Shraddhanand College, University of Delhi
- Department of Chemistry, Babasaheb Bhimrao Ambedkar University,
- Issue: Vol 24, No 7 (2024)
- Pages: 488-503
- Section: Oncology
- URL: https://rjsocmed.com/1871-5206/article/view/644256
- DOI: https://doi.org/10.2174/0118715206280314231201111358
- ID: 644256
Cite item
Full Text
Abstract
Over the last few decades, an alarming rise in the percentage of individuals with cancer and those with multi-resistant illnesses has forced researchers to explore possibilities for novel therapeutic approaches. Numerous medications currently exist to treat various disorders, and the development of small molecules as anticancer agents has considerable potential. However, the widespread prevalence of resistance to multiple drugs in cancer indicates that it is necessary to discover novel and promising compounds with ideal characteristics that could overcome the multidrug resistance issue. The utilisation of metallo-drugs has served as a productive anticancer chemotherapeutic method, and this approach may be implemented for combating multi-resistant tumours more successfully. Schiff bases have been receiving a lot of attention as a group of compounds due to their adaptable metal chelating abilities, innate biologic properties, and versatility to tweak the structure to optimise it for a specific biological purpose. The biological relevance of Schiff base and related complexes, notably their anticancer effects, has increased in their popularity as bio-inorganic chemistry has progressed. As a result of learning about Schiff bases antitumor efficacy against multiple cancer cell lines and their complexes, researchers are motivated to develop novel, side-effect-free anticancer treatments. According to study reports from the past ten years, we are still seeking a powerful anticancer contender. This study highlights the potential of Schiff bases, a broad class of chemical molecules, as potent anticancer agents. In combination with other anticancer strategies, they enhance the efficacy of treatment by elevating the cytotoxicity of chemotherapy, surmounting drug resistance, and promoting targeted therapy. Schiff bases also cause cancer cell DNA repair, improve immunotherapy, prevent angiogenesis, cause apoptosis, and lessen the side effects of chemotherapy. The present review explores the development of potential Schiff base and their d and f block metal complexes as anticancer agents against various cancer cell lines.
Keywords
About the authors
Presenjit
Radiological Nuclear and Imaging Science, Institute of Nuclear Medicine & Allied Sciences, DRDO
Email: info@benthamscience.net
Shubhra Chaturvedi
Radiological Nuclear and Imaging Science, Institute of Nuclear Medicine & Allied Sciences, DRDO
Email: info@benthamscience.net
Akanksha Singh
Department of Zoology, Swami Shraddhanand College, University of Delhi
Email: info@benthamscience.net
Divya Gautam
Radiological Nuclear and Imaging Science, Institute of Nuclear Medicine & Allied Sciences, DRDO
Email: info@benthamscience.net
Kaman Singh
Department of Chemistry, Babasaheb Bhimrao Ambedkar University,
Author for correspondence.
Email: info@benthamscience.net
Anil Mishra
Radiological Nuclear and Imaging Science, Institute of Nuclear Medicine & Allied Sciences, DRDO
Author for correspondence.
Email: info@benthamscience.net
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