Advances in iPSC Technology in Neural Disease Modeling, Drug Screening, and Therapy

  • Авторы: Dai S.1, Qiu L.1, Veeraraghavan V.2, Sheu C.1, Mony U.3
  • Учреждения:
    1. Department of Biomedical Engineering, Shantou University
    2. Centre of Molecular Medicine and Diagnostics (COMManD), Department of Biochemistry, Saveetha Dental College and Hospitals,, Saveetha Institute of Medical and Technical Sciences, Saveetha University
    3. Centre of Molecular Medicine and Diagnostics (COMManD), Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University,
  • Выпуск: Том 19, № 6 (2024)
  • Страницы: 809-819
  • Раздел: Medicine
  • URL: https://rjsocmed.com/1574-888X/article/view/645851
  • DOI: https://doi.org/10.2174/1574888X18666230608105703
  • ID: 645851

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Аннотация

Neurodegenerative disorders (NDs) including Alzheimer’s Disease, Parkinson’s Disease, Amyotrophic Lateral Sclerosis (ALS), and Huntington's disease are all incurable and can only be managed with drugs for the associated symptoms. Animal models of human illnesses help to advance our understanding of the pathogenic processes of diseases. Understanding the pathogenesis as well as drug screening using appropriate disease models of neurodegenerative diseases (NDs) are vital for identifying novel therapies. Human-derived induced pluripotent stem cell (iPSC) models can be an efficient model to create disease in a dish and thereby can proceed with drug screening and identifying appropriate drugs. This technology has many benefits, including efficient reprogramming and regeneration potential, multidirectional differentiation, and the lack of ethical concerns, which open up new avenues for studying neurological illnesses in greater depth. The review mainly focuses on the use of iPSC technology in neuronal disease modeling, drug screening, and cell therapy.

Об авторах

Sihan Dai

Department of Biomedical Engineering, Shantou University

Email: info@benthamscience.net

Linhui Qiu

Department of Biomedical Engineering, Shantou University

Email: info@benthamscience.net

Vishnu Veeraraghavan

Centre of Molecular Medicine and Diagnostics (COMManD), Department of Biochemistry, Saveetha Dental College and Hospitals,, Saveetha Institute of Medical and Technical Sciences, Saveetha University

Email: info@benthamscience.net

Chia-Lin Sheu

Department of Biomedical Engineering, Shantou University

Автор, ответственный за переписку.
Email: info@benthamscience.net

Ullas Mony

Centre of Molecular Medicine and Diagnostics (COMManD), Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University,

Автор, ответственный за переписку.
Email: info@benthamscience.net

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