Research Progress on the Effect of Autophagy and Exosomes on Liver Fibrosis


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Abstract

Chronic liver disease is a known risk factor for the development of liver cancer, and the development of microRNA (miRNA) liver therapies has been hampered by the difficulty of delivering miRNA to damaged tissues. In recent years, numerous studies have shown that hepatic stellate cell (HSC) autophagy and exosomes play an important role in maintaining liver homeostasis and ameliorating liver fibrosis. In addition, the interaction between HSC autophagy and exosomes also affects the progression of liver fibrosis. In this paper, we review the research progress of mesenchymal stem cell-derived exosomes (MSC-EVs) loaded with specific miRNA and autophagy, and their related signaling pathways in liver fibrosis, which will provide a more reliable basis for the use of MSC-EVs for therapeutic delivery of miRNAs targeting the chronic liver disease.

About the authors

Yikuan Du

Central Laboratory, Affiliated Dongguan Hospital,, Southern Medical University,

Email: info@benthamscience.net

Silin Zhu

Dongguan Key Laboratory of Stem Cell and Regenerative Tissue Engineering, Guangdong Medical University,

Email: info@benthamscience.net

Haojie Zeng

Dongguan Key Laboratory of Stem Cell and Regenerative Tissue Engineering, Guangdong Medical University,

Email: info@benthamscience.net

Zhenjie Wang

Dongguan Key Laboratory of Stem Cell and Regenerative Tissue Engineering,, Guangdong Medical University

Email: info@benthamscience.net

Yixing Huang

Dongguan Key Laboratory of Stem Cell and Regenerative Tissue Engineering, Guangdong Medical University,

Email: info@benthamscience.net

Yuqi Zhou

Dongguan Key Laboratory of Stem Cell and Regenerative Tissue Engineering, Guangdong Medical University,

Email: info@benthamscience.net

Weichui Zhang

Dongguan Key Laboratory of Stem Cell and Regenerative Tissue Engineering, Guangdong Medical University,

Email: info@benthamscience.net

Jinfeng Zhu

Dongguan Key Laboratory of Stem Cell and Regenerative Tissue Engineering, Guangdong Medical University

Email: info@benthamscience.net

Chun Yang

Dongguan Key Laboratory of Stem Cell and Regenerative Tissue Engineering, Guangdong Medical University,

Author for correspondence.
Email: info@benthamscience.net

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