Real-World Effectiveness of Cladribine for Patients with Multiple Sclerosis: A Sicilian Multicentric Experience (Rewind Study)
- 作者: Arena S.1, Chisari C.1, Toscano S.1, Bucello S.2, Grimaldi L.3, Ragonese P.4, Realmuto S.5, Cottone S.6, Maimone D.7, Finocchiaro C.1, Reitano P.1, Patti F.1
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隶属关系:
- Department "GF Ingrassia" Section of Neurosciences, University of Catania
- , Multiple Sclerosis Center- PO Muscatello di Augusta
- , Institute Foundation "G. Giglio", Multiple Sclerosis Centre
- Department of Biomedicine, Neurosciences and Advanced Diagnostics (BiND), University of Palermo
- Multiple Sclerosis Centre, Neurology Unit and Stroke Unit, AOOR "Villa Sofia- Cervello", United Hospitals,
- , Azienda Ospedaliera di Rilievo Nazionale e di Alta Specializzazione "Civico Di Cristina e Benfratelli"
- Centro Sclerosi Multipla, UOC Neurologia, ARNAS Garibaldi
- 期: 卷 22, 编号 7 (2024)
- 页面: 1271-1283
- 栏目: Neurology
- URL: https://rjsocmed.com/1570-159X/article/view/644852
- DOI: https://doi.org/10.2174/1570159X21666230322140711
- ID: 644852
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全文:
详细
Background:Cladribine tablets are a highly effective option for the treatment of relapsingremitting multiple sclerosis (RRMS).
Objective:The study aims to evaluate the effectiveness of cladribine in a real-world setting.
Methods:This prospective real-world study consecutively screened all RRMS patients from seven different MS centers in Sicily (Italy) who completed the 2-year treatment course of cladribine tablets in the period between 11th March 2019 and 31st October 2021. Data about Expanded Disability Status Scale (EDSS), relapses, previous treatments, adverse events (AEs) and magnetic resonance imaging (MRI) were collected. Patients who were previously treated with other DMTs were further stratified into moderately active treatment (MAT) and highly active treatment (HAT) patients.
Results:A total of 217 patients (70% women, with a mean age of 38.4 ± 11.3 years) were enrolled. Fifty patients (23.0%) were naïve to treatment and 167 (77%) switched from other disease modifying therapies. After the second year of treatment, about 80% were EDSS progression free, 88% remained relapse-free at T24, and 48% of patients were MRI activity-free. Kaplan Meier analyses showed significant differences between MT and HAT in terms of time to first clinical relapse (HR: 2.43, IC 1.02- 5.76; p = 0.04), time to the first new T1-gadolinium enhancing lesion (HR: 3.43, IC 1.35-8.70; p = 0.009) and time to MRI worsening (HR: 2.42, IC 1.15-5.09; p = 0.02).
Conclusion:This study confirmed that cladribine is an effective treatment for MS, particularly in naïve patients and those who have switched from MATs.
作者简介
Sebastiano Arena
Department "GF Ingrassia" Section of Neurosciences, University of Catania
Email: info@benthamscience.net
Clara Chisari
Department "GF Ingrassia" Section of Neurosciences, University of Catania
Email: info@benthamscience.net
Simona Toscano
Department "GF Ingrassia" Section of Neurosciences, University of Catania
Email: info@benthamscience.net
Sebastiano Bucello
, Multiple Sclerosis Center- PO Muscatello di Augusta
Email: info@benthamscience.net
Luigi Grimaldi
, Institute Foundation "G. Giglio", Multiple Sclerosis Centre
Email: info@benthamscience.net
Paolo Ragonese
Department of Biomedicine, Neurosciences and Advanced Diagnostics (BiND), University of Palermo
Email: info@benthamscience.net
Sabrina Realmuto
Multiple Sclerosis Centre, Neurology Unit and Stroke Unit, AOOR "Villa Sofia- Cervello", United Hospitals,
Email: info@benthamscience.net
Salvatore Cottone
, Azienda Ospedaliera di Rilievo Nazionale e di Alta Specializzazione "Civico Di Cristina e Benfratelli"
Email: info@benthamscience.net
Davide Maimone
Centro Sclerosi Multipla, UOC Neurologia, ARNAS Garibaldi
Email: info@benthamscience.net
Chiara Finocchiaro
Department "GF Ingrassia" Section of Neurosciences, University of Catania
Email: info@benthamscience.net
Paola Reitano
Department "GF Ingrassia" Section of Neurosciences, University of Catania
Email: info@benthamscience.net
Francesco Patti
Department "GF Ingrassia" Section of Neurosciences, University of Catania
编辑信件的主要联系方式.
Email: info@benthamscience.net
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