Potential Therapeutic Effects of Short-Chain Fatty Acids on Chronic Pain


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Abstract

The intestinal homeostasis maintained by the gut microbiome and relevant metabolites is essential for health, and its disturbance leads to various intestinal or extraintestinal diseases. Recent studies suggest that gut microbiome-derived metabolites short-chain fatty acids (SCFAs) are involved in different neurological disorders (such as chronic pain). SCFAs are produced by bacterial fermentation of dietary fibers in the gut and contribute to multiple host processes, including gastrointestinal regulation, cardiovascular modulation, and neuroendocrine-immune homeostasis. Although SCFAs have been implicated in the modulation of chronic pain, the detailed mechanisms that underlie such roles of SCFAs remain to be further investigated. In this review, we summarize currently available research data regarding SCFAs as a potential therapeutic target for chronic pain treatment and discuss several possible mechanisms by which SCFAs modulate chronic pain.

About the authors

Yuanyuan Tang

School of Basic Medical Sciences, Xinxiang Medical University

Email: info@benthamscience.net

Juan Du

School of Basic Medical Sciences, Xinxiang Medical University

Email: info@benthamscience.net

Hongfeng Wu

School of Basic Medical Sciences, Xinxiang Medical University

Email: info@benthamscience.net

Mengyao Wang

School of Basic Medical Sciences, Xinxiang Medical University

Email: info@benthamscience.net

Sufang Liu

Department of Biomedical Sciences, College of Dentistry,, Texas A&M University Dallas

Author for correspondence.
Email: info@benthamscience.net

Feng Tao

Department of Biomedical Sciences, College of Dentistry, Texas A&M University Dallas

Author for correspondence.
Email: info@benthamscience.net

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