Future Directions for Developing Non-dopaminergic Strategies for the Treatment of Parkinson’s Disease


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Abstract

The symptomatic treatment of Parkinson’s disease (PD) has been dominated by the use of dopaminergic medication, but significant unmet need remains, much of which is related to non-motor symptoms and the involvement of non-dopaminergic transmitter systems. As such, little has changed in the past decades that has led to milestone advances in therapy and significantly improved treatment paradigms and patient outcomes, particularly in relation to symptoms unresponsive to levodopa. This review has looked at how pharmacological approaches to treatment are likely to develop in the near and distant future and will focus on two areas: 1) novel non-dopaminergic pharmacological strategies to control motor symptoms; and 2) novel non-dopaminergic approaches for the treatment of non-motor symptoms. The overall objective of this review is to use a ‘crystal ball’ approach to the future of drug discovery in PD and move away from the more traditional dopamine-based treatments. Here, we discuss promising non-dopaminergic and ‘dirty drugs’ that have the potential to become new key players in the field of Parkinson’s disease treatment.

About the authors

Daniel Wamelen

Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience,, King’s College London

Author for correspondence.
Email: info@benthamscience.net

Valentina Leta

Department of Basic & Clinical Neuroscience, Institute of Psychiatry, Psychology & Neuroscience,, King’s College London

Email: info@benthamscience.net

K. Ray Chaudhuri

Department of Basic & Clinical Neuroscience, Institute of Psychiatry, Psychology & Neuroscience, King’s College London

Email: info@benthamscience.net

Peter Jenner

School of Cancer & Pharmaceutical Sciences, Institute of Pharmaceutical Science, King’s College London

Email: info@benthamscience.net

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