Is Pain a Symptom or a Disease? How Does the New Evidence Help to Better Understand this Unsolved Question?


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Massimo Allegri

Centre lémanique de neuromodulation et thérapie de la douleur, Ensemble Hospitalier de la Côte

Email: info@benthamscience.net

Bibliografia

  1. Scholz, J.; Finnerup, N.B.; Attal, N.; Aziz, Q.; Baron, R.; Bennett, M.I.; Benoliel, R.; Cohen, M.; Cruccu, G.; Davis, K.D.; Evers, S.; First, M.; Giamberardino, M.A.; Hansson, P.; Kaasa, S.; Korwisi, B.; Kosek, E.; Lavand’homme, P.; Nicholas, M.; Nurmikko, T.; Perrot, S.; Raja, S.N.; Rice, A.S.C.; Rowbotham, M.C.; Schug, S.; Simpson, D.M.; Smith, B.H.; Svensson, P.; Vlaeyen, J.W.S.; Wang, S.J.; Barke, A.; Rief, W.; Treede, R.D. The IASP classification of chronic pain for ICD-11: Chronic neuropathic pain. Pain, 2019, 160(1), 53-59. doi: 10.1097/j.pain.0000000000001365 PMID: 30586071
  2. Cohen, M; Quintner, J; Weisman, A. "Nociplastic Pain": A challenge to nosology and to nociception. J Pain., 2023, S1526-5900(23)00483-2. doi: 10.1016/j.jpain.2023.07.019
  3. Lavand’homme, P. ‘Why me?’ The problem of chronic pain after surgery. Br. J. Pain, 2017, 11(4), 162-165. doi: 10.1177/2049463717722119 PMID: 29123659
  4. Parisien, M.; van Reij, R.R.I.; Khoury, S.; Koseli, E.; Karaky, M.; van den Hoogen, N.J.; Peng, G.; Allegri, M.; de Gregori, M.; Chelly, J.E.; Rakel, B.A.; Aasvang, E.K.; Kehlet, H.; Buhre, W.F.F.A.; Bryant, C.D.; Damaj, M.I.; King, I.L.; Mogil, J.S.; Joosten, E.A.J.; Diatchenko, L. Genome-wide association study suggests a critical contribution of the adaptive immune system to chronic post-surgical pain. medRxiv, 2023, 2023.01.24.23284520. doi: 10.1101/2023.01.24.23284520
  5. Parisien, M.; Lima, L.V.; Dagostino, C.; El-Hachem, N.; Drury, G.L.; Grant, A.V.; Huising, J.; Verma, V.; Meloto, C.B.; Silva, J.R.; Dutra, G.G.S.; Markova, T.; Dang, H.; Tessier, P.A.; Slade, G.D.; Nackley, A.G.; Ghasemlou, N.; Mogil, J.S.; Allegri, M.; Diatchenko, L. Acute inflammatory response via neutrophil activation protects against the development of chronic pain. Sci. Transl. Med., 2022, 14(644), eabj9954. doi: 10.1126/scitranslmed.abj9954 PMID: 35544595
  6. Calvo, M.; Dawes, J.M.; Bennett, D.L.H. The role of the immune system in the generation of neuropathic pain. Lancet Neurol., 2012, 11(7), 629-642. doi: 10.1016/S1474-4422(12)70134-5 PMID: 22710756
  7. Wang, F.; Cheung, C.W.; Wong, S.S.C. Regenerative medicine for the treatment of chronic low back pain: A narrative review. J. Int. Med. Res., 2023, 51(2), 300060523115577. doi: 10.1177/03000605231155777 PMID: 36802994

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