Herbal Medicines - A Fruitful Approach to Periodic Illness Dysmenorrhoea: Evidence-based Review


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Abstract

Dysmenorrhea (menstrual or periodic pain) is a discomfort that occurs during painful periods. It is the first and most prominent reason for female lower abdominal pain. Most adolescent girls consider it a curse due to the periodic occurrence of painful cramps and bleeding. The pathogenesis of painful periods is most likely because of increased prostanoids, notably prostaglandins, produced by the cyclooxygenase pathway (PGs). Misuse of synthetic medications leads to the development of medication resistance and deposits toxic residues in the body; thus, there is a critical need for safe and effective alternatives. In recent decades, herbal treatment approaches have found extensive applications in the treatment of various ailments. Herbal therapies are an alternate source, which include several bioactive chemicals, and recent improvements in our understanding of the value of herbal therapy methods have caused a sharp rise in their production. The main focus of this review was to study herbal treatment options; the recent studies conducted on herbal therapies and various experimental investigations on dysmenorrhea and herbal therapy methods have been studied, and randomized controlled trials and animal models have been discussed describing the anti-inflammatory properties of some potential herbal medicines that can be used as treatment options for dysmenorrhoea. This review aimed to present herbal treatments that can be used as alternative traditional synthetic medications and oral hormonal contraceptives in the treatment of painful menstruation.

About the authors

Keshav Bansal

Institute of Pharmaceutical Research, GLA University

Author for correspondence.
Email: info@benthamscience.net

Sachin Sharma

Institute of Pharmaceutical Research, GLA University

Email: info@benthamscience.net

Meenakshi Bajpai

Institute of Pharmaceutical Research, GLA University

Email: info@benthamscience.net

References

  1. Guimarães, I.; Póvoa, A.M. Primary dysmenorrhea: assessment and treatment. Rev. Bras. Ginecol. Obstet., 2020, 42(8), 501-507. doi: 10.1055/s-0040-1712131 PMID: 32559803
  2. Ferries-Rowe, E.; Corey, E.; Archer, J.S. Primary Dysmenorrhea. Obstet. Gynecol., 2020, 136(5), 1047-1058. doi: 10.1097/AOG.0000000000004096 PMID: 33030880
  3. Gupta, R.; Gupta, J.; Kumar, D. Alternative approaches for rheumatoid arthritis management: future perspective, herbal, dietary, lifestyle, psychological, nutritional intervention and healthcare. J. Pharm. Res. Int., 2021, 33(54A), 342-363. doi: 10.9734/jpri/2021/v33i54A33756
  4. Gupta, R.; Sharma, S. herbal antibiotics: a review. bulletin of environment. Pharmacol Life Sci., 2020, 9(11), 136-142.
  5. Itani, R.; Soubra, L.; Karout, S.; Rahme, D.; Karout, L.; Khojah, H.M.J. Primary dysmenorrhea: pathophysiology, diagnosis, and treatment updates. Korean J. Fam. Med., 2022, 43(2), 101-108. doi: 10.4082/kjfm.21.0103 PMID: 35320895
  6. Gutman, G.; Nunez, A.T.; Fisher, M. Dysmenorrhea in adolescents. Curr. Probl. Pediatr. Adolesc. Health Care, 2022, 52(5), 101186. doi: 10.1016/j.cppeds.2022.101186 PMID: 35523674
  7. Davis, A.R.; Westhoff, C.L. Primary dysmenorrhea in adolescent girls and treatment with oral contraceptives. J. Pediatr. Adolesc. Gynecol., 2001, 14(1), 3-8. doi: 10.1016/S1083-3188(00)00076-0 PMID: 11358700
  8. Dawood, M.Y. Primary Dysmenorrhea. Obstet. Gynecol., 2006, 108(2), 428-441. doi: 10.1097/01.AOG.0000230214.26638.0c PMID: 16880317
  9. Schoep, M.E.; Adang, E.M.M.; Maas, J.W.M.; De Bie, B.; Aarts, J.W.M.; Nieboer, T.E. Productivity loss due to menstruation-related symptoms: a nationwide cross-sectional survey among 32 748 women. BMJ Open, 2019, 9(6), e026186. doi: 10.1136/bmjopen-2018-026186 PMID: 31248919
  10. Morrow, C.; Naumburg, E.H. Dysmenorrhea. Prim. Care, 2009, 36(1), 19-32. vii. doi: 10.1016/j.pop.2008.10.004 PMID: 19231600
  11. Friederich, M.A. Dysmenorrhoea.In lifting the curse of menstruation a feminist appraisal of the influence of menstruation on women’s lives New York: Routeledge; Golub, S., Ed.; Taylor and Francis: London, 2017, pp. 91-106. doi: 10.4324/9781315866116-5
  12. Harel, Z. Dysmenorrhea in adolescents and young adults: etiology and management. J. Pediatr. Adolesc. Gynecol., 2006, 19(6), 363-371. doi: 10.1016/j.jpag.2006.09.001 PMID: 17174824
  13. Osayande, A.S.; Mehulic, S. Diagnosis and initial management of dysmenorrhea. Am. Fam. Physician, 2014, 89(5), 341-346. PMID: 24695505
  14. Weissman, A.M.; Hartz, A.J.; Hansen, M.D.; Johnson, S.R. The natural history of primary dysmenorrhoea: a longitudinal study. BJOG, 2004, 111(4), 345-352. doi: 10.1111/j.1471-0528.2004.00090.x PMID: 15008771
  15. Sachedin, A.; Todd, N. Dysmenorrhea, endometriosis and chronic pelvic pain in adolescents. J. Clin. Res. Pediatr. Endocrinol., 2020, 12(1), 7-17. doi: 10.4274/jcrpe.galenos.2019.2019.S0217 PMID: 32041388
  16. Durain, D. Primary dysmenorrhea: assessment and management update. J. Midwifery Womens Health, 2004, 49(6), 520-528. doi: 10.1016/j.jmwh.2004.08.013 PMID: 15544981
  17. Sanfilippo, J.; Erb, T. Evaluation and management of dysmenorrhea in adolescents. Clin. Obstet. Gynecol., 2008, 51(2), 257-267. doi: 10.1097/GRF.0b013e31816d2307 PMID: 18463457
  18. Doty, E.; Attaran, M. Managing primary dysmenorrhea. J. Pediatr. Adolesc. Gynecol., 2006, 19(5), 341-344. doi: 10.1016/j.jpag.2006.06.005 PMID: 17060018
  19. Iacovides, S.; Avidon, I.; Baker, F.C. What we know about primary dysmenorrhea today: a critical review. Hum. Reprod. Update, 2015, 21(6), 762-778. doi: 10.1093/humupd/dmv039 PMID: 26346058
  20. Ruoff, G.; Lema, M. Strategies in pain management: new and potential indications for COX-2 specific inhibitors. J. Pain Symptom Manage., 2003, 25(2)(Suppl.), 21-31. doi: 10.1016/S0885-3924(02)00628-0 PMID: 12604154
  21. French, L. Dysmenorrhea in Adolescents. Paediatr. Drugs, 2008, 10(1), 1-7. doi: 10.2165/00148581-200810010-00001 PMID: 18162003
  22. Granot, M.; Yarnitsky, D.; Itskovitz-Eldor, J.; Granovsky, Y.; Peer, E.; Zimmer, E.Z. Pain perception in women with dysmenorrhea. Obstet. Gynecol., 2001, 98(3), 407-411. PMID: 11530120
  23. Ju, H.; Jones, M.; Mishra, G. The prevalence and risk factors of dysmenorrhea. Epidemiol. Rev., 2014, 36(1), 104-113. doi: 10.1093/epirev/mxt009 PMID: 24284871
  24. Wang, L.; Yan, Y.; Qiu, H.; Xu, D.; Zhu, J.; Liu, J. Prevalence and risk factors of primary dysmenorrhea in students: a meta-analysis. Value Health, 2022, 2022, S1098-S3015. doi: 10.1016/j.jval.2022.03.023
  25. Ohde, S.; Tokuda, Y.; Takahashi, O.; Yanai, H.; Hinohara, S.; Fukui, T. Dysmenorrhea among Japanese women. Int. J. Gynaecol. Obstet., 2008, 100(1), 13-17. doi: 10.1016/j.ijgo.2007.06.039 PMID: 17888923
  26. Wang, L.; Wang, X.; Wang, W.; Chen, C.; Ronnennberg, A.G.; Guang, W.; Huang, A.; Fang, Z.; Zang, T.; Wang, L.; Xu, X. Stress and dysmenorrhoea: a population based prospective study. Occup. Environ. Med., 2004, 61(12), 1021-1026. doi: 10.1136/oem.2003.012302 PMID: 15550609
  27. Abenhaim, H.A.; Harlow, B.L. Live births, cesarean sections and the development of menstrual abnormalities. Int. J. Gynaecol. Obstet., 2006, 92(2), 111-116. doi: 10.1016/j.ijgo.2005.10.011 PMID: 16376346
  28. Burnett, M.A.; Antao, V.; Black, A.; Feldman, K.; Grenville, A.; Lea, R.; Lefebvre, G.; Pinsonneault, O.; Robert, M. Prevalence of primary dysmenorrhea in Canada. J. Obstet. Gynaecol. Can., 2005, 27(8), 765-770. doi: 10.1016/S1701-2163(16)30728-9 PMID: 16287008
  29. Harlow, B.L.; Missmer, S.A.; Cramer, D.W.; Barbieri, R.L. Does tubal sterilization influence the subsequent risk of menorrhagia or dysmenorrhea? Fertil. Steril., 2002, 77(4), 754-760. doi: 10.1016/S0015-0282(01)03253-8 PMID: 11937129
  30. László, K.D. GyŐrffy, Z.; Ádám, S.; Csoboth, C.; Kopp, M.S. Work-related stress factors and menstrual pain: a nation-wide representative survey. J. Psychosom. Obstet. Gynaecol., 2008, 29(2), 133-138. doi: 10.1080/01674820701804423 PMID: 18484442
  31. László, K.D.; Kopp, M.S. Effort-reward imbalance and overcommitment at work are associated with painful menstruation: results from the Hungarostudy Epidemiological Panel 2006. J. Occup. Environ. Med., 2009, 51(2), 157-163. doi: 10.1097/JOM.0b013e318197ca89 PMID: 19209036
  32. Nohara, M.; Momoeda, M.; Kubota, T.; Nakabayashi, M. Menstrual cycle and menstrual pain problems and related risk factors among Japanese female workers. Ind. Health, 2010, (Aug), 1012100044. PMID: 21173526
  33. Patel, V.; Tanksale, V.; Sahasrabhojanee, M.; Gupte, S.; Nevrekar, P. The burden and determinants of dysmenorrhoea: a population-based survey of 2262 women in Goa, India. BJOG, 2006, 113(4), 453-463. doi: 10.1111/j.1471-0528.2006.00874.x PMID: 16489934
  34. Pawłowski, B. Prevalence of menstrual pain in relation to the reproductive life history of women from the Mayan rural community. Ann. Hum. Biol., 2004, 31(1), 1-8. doi: 10.1080/03014460310001602072 PMID: 14742161
  35. Vivian, D.; Barnard, A. Prevalence and correlates of three types of pelvic pain in a nationally representative sample of Australian women. Med. J. Aust., 2009, 190(1), 47-48. doi: 10.5694/j.1326-5377.2009.tb02269.x PMID: 19266629
  36. Santer, M.; Warner, P.; Wyke, S. A Scottish postal survey suggested that the prevailing clinical preoccupation with heavy periods does not reflect the epidemiology of reported symptoms and problems. J. Clin. Epidemiol., 2005, 58(11), 1206-1210. doi: 10.1016/j.jclinepi.2005.02.026 PMID: 16223665
  37. Tavallaee, M.; Joffres, M.R.; Corber, S.J.; Bayanzadeh, M.; Rad, M.M. The prevalence of menstrual pain and associated risk factors among Iranian women. J. Obstet. Gynaecol. Res., 2011, 37(5), 442-451. doi: 10.1111/j.1447-0756.2010.01362.x PMID: 21208343
  38. Unsal, A.; Tozun, M.; Aslan, G.; Ayranci, U.; Alkan, G. Evaluation of dysmenorrhea among women and its impact on quality of life in a region of western turkey. Pak. J. Med. Sci., 2010, 26(1), 142-147.
  39. Coco, A.S. Primary dysmenorrhea. Am. Fam. Physician, 1999, 60(2), 489-496. PMID: 10465224
  40. Feng, X.; Wang, X. Comparison of the efficacy and safety of non-steroidal anti-inflammatory drugs for patients with primary dysmenorrhea: A network meta-analysis. Mol. Pain, 2018, 14(111) doi: 10.1177/1744806918770320 PMID: 29587566
  41. Marjoribanks, J.; Proctor, M.L.; Farquhar, C.; Sangkomkamhang, U.S.; Derks, R.S. Nonsteroidal anti-inflammatory drugs for primary dysmenorrhoea. Cochrane Database Syst. Rev., 2003, (4), CD001751. PMID: 14583938
  42. McCOOL WF. W.F. Varney’s midwifery, 4th Edi; Jones and bartlett publishers, 2004.
  43. Bulletin, A.P. ACOG Practice Bulletin No. 110: noncontraceptive uses of hormonal contraceptives. Obstet. Gynecol., 2010, 115(1), 206-218. doi: 10.1097/AOG.0b013e3181cb50b5 PMID: 20027071
  44. Burnett, M.; Lemyre, M. No. 345-Primary Dysmenorrhea Consensus Guideline. J. Obstet. Gynaecol. Can., 2017, 39(7), 585-595. doi: 10.1016/j.jogc.2016.12.023 PMID: 28625286
  45. Stewart, F.H.; Kaunitz, A.M.; LaGuardia, K.D.; Karvois, D.L.; Fisher, A.C.; Friedman, A.J. Extended use of transdermal norelgestromin/ethinyl estradiol: a randomized trial. Obstet. Gynecol., 2005, 105(6), 1389-1396. doi: 10.1097/01.AOG.0000160430.61799.f6 PMID: 15932834
  46. Milsom, I.; Lete, I.; Bjertnaes, A.; Rokstad, K.; Lindh, I.; Gruber, C.J.; Birkhäuser, M.H.; Aubeny, E.; Knudsen, T.; Bastianelli, C. Effects on cycle control and bodyweight of the combined contraceptive ring, NuvaRing, versus an oral contraceptive containing 30 g ethinyl estradiol and 3 mg drospirenone. Hum. Reprod., 2006, 21(9), 2304-2311. doi: 10.1093/humrep/del162 PMID: 16763008
  47. Dunn, N. Oral contraceptives and venous thromboembolism. BMJ, 2009, 339(aug13 2), b3164. doi: 10.1136/bmj.b3164 PMID: 19679617
  48. Sergison, J.E.; Maldonado, L.Y.; Gao, X.; Hubacher, D. Levonorgestrel intrauterine system associated amenorrhea: a systematic review and metaanalysis. Am. J. Obstet. Gynecol., 2019, 220(5), 440-448.e8. doi: 10.1016/j.ajog.2018.12.008 PMID: 30527945
  49. Hubacher, D.; Lopez, L.; Steiner, M.J.; Dorflinger, L. Menstrual pattern changes from levonorgestrel subdermal implants and DMPA: systematic review and evidence-based comparisons. Contraception, 2009, 80(2), 113-118. doi: 10.1016/j.contraception.2009.02.008 PMID: 19631785
  50. Berenson, A.B.; Rahman, M.; Breitkopf, C.R.; Bi, L.X. Effects of depot medroxyprogesterone acetate and 20-microgram oral contraceptives on bone mineral density. Obstet. Gynecol., 2008, 112(4), 788-799. doi: 10.1097/AOG.0b013e3181875b78 PMID: 18827121
  51. Hansen, S.O.; Knudsen, U.B. Endometriosis, dysmenorrhoea and diet. Eur. J. Obstet. Gynecol. Reprod. Biol., 2013, 169(2), 162-171. doi: 10.1016/j.ejogrb.2013.03.028 PMID: 23642910
  52. Pattanittum, P.; Kunyanone, N.; Brown, J.; Sangkomkamhang, U.S.; Barnes, J.; Seyfoddin, V.; Marjoribanks, J. Dietary supplements for dysmenorrhoea. Cochrane Database Syst. Rev., 2016, 3(3), CD002124. PMID: 27000311
  53. Armour, M.; Ee, C.C.; Naidoo, D.; Ayati, Z.; Chalmers, K.J.; Steel, K.A.; de Manincor, M.J.; Delshad, E. Exercise for dysmenorrhoea. Cochrane Database Syst. Rev., 2019, 9(9), CD004142. PMID: 31538328
  54. Al-Husban, N.; Odeh, O.; Dabit, T.; Masadeh, A. The Influence of Lifestyle Variables on Primary Dysmenorrhea: A Cross-Sectional Study. Int. J. Womens Health, 2022, 14, 545-553. doi: 10.2147/IJWH.S338651 PMID: 35444471
  55. Jo, J.; Lee, S.H. Heat therapy for primary dysmenorrhea: A systematic review and meta-analysis of its effects on pain relief and quality of life. Sci. Rep., 2018, 8(1), 16252. doi: 10.1038/s41598-018-34303-z PMID: 30389956
  56. Potur, D.C.; Kömürcü, N. The effects of local low-dose heat application on dysmenorrhea. J. Pediatr. Adolesc. Gynecol., 2014, 27(4), 216-221. doi: 10.1016/j.jpag.2013.11.003 PMID: 24656704
  57. Arik, M.I.; Kiloatar, H.; Aslan, B.; Icelli, M. The effect of TENS for pain relief in women with primary dysmenorrhea: A systematic review and meta-analysis. Explore (NY), 2022, 18(1), 108-113. doi: 10.1016/j.explore.2020.08.005 PMID: 32917532
  58. Elboim-Gabyzon, M.; Kalichman, L. Transcutaneous electrical nerve stimulation (tens) for primary dysmenorrhea: An Overview. Int. J. Womens Health, 2020, 12, 1-10. doi: 10.2147/IJWH.S220523 PMID: 32021488
  59. Zhao, L.; Li, P. A survey of acupuncture treatment for primary dysmenorrhea. J. Tradit. Chin. Med., 2009, 29(1), 71-76. doi: 10.1016/S0254-6272(09)60035-2 PMID: 19514193
  60. Smith, C.A.; Armour, M.; Zhu, X.; Li, X.; Lu, Z.Y.; Song, J. Acupuncture for dysmenorrhoea. Cochrane Database Syst. Rev., 2016, 4(4), CD007854. PMID: 27087494
  61. Proctor, M.; Farquhar, C. Diagnosis and management of dysmenorrhoea. BMJ, 2006, 332(7550), 1134-1138. doi: 10.1136/bmj.332.7550.1134 PMID: 16690671
  62. Wyatt, S.N.; Banahan, T.; Tang, Y.; Nadendla, K.; Szychowski, J.M.; Jenkins, T.R. Effect of radiofrequency endometrial ablation on dysmenorrhea. J. Minim. Invasive Gynecol., 2016, 23(7), 1163-1166. doi: 10.1016/j.jmig.2016.08.825 PMID: 27590567
  63. Darwish, M.; Atlantis, E.; Mohamed-Taysir, T. Psychological outcomes after hysterectomy for benign conditions: a systematic review and meta-analysis. Eur. J. Obstet. Gynecol. Reprod. Biol., 2014, 174(1), 5-19. doi: 10.1016/j.ejogrb.2013.12.017 PMID: 24398028
  64. Bougie, O.; Suen, M.W.; Pudwell, J.; MacGregor, B.; Plante, S.; Nitsch, R.; Singh, S.S. Evaluating the prevalence of regret with the decision to proceed with a hysterectomy in women younger than age 35. J. Obstet. Gynaecol. Can., 2020, 42(3), 262-268.e3. doi: 10.1016/j.jogc.2019.08.006 PMID: 31734156
  65. Jaleel, G.; Shaphe, M.A.; Khan, A.R.; Malhotra, D.; Khan, H.; Parveen, S.; Qasheesh, M.; Beg, R.A.; Chahal, A.; Ahmad, F.; Ahmad, M.F. Effect of exercises on central and endocrine system for pain modulation in primary dysmenorrhea. J. Lifestyle Med., 2022, 12(1), 15-25. doi: 10.15280/jlm.2022.12.1.15 PMID: 35300040
  66. Morgan, P.J.; Kung, R.; Tarshis, J. Nitroglycerin as a uterine relaxant: a systematic review. J. Obstet. Gynaecol. Can., 2002, 24(5), 403-409. doi: 10.1016/S1701-2163(16)30403-0 PMID: 12196860
  67. Moya, R.A.; Moisa, C.F.; Morales, F.; Wynter, H.; Ali, A.; Narancio, E. Transdermal glyceryl trinitrate in the management of primary dysmenorrhea. Int. J. Gynaecol. Obstet., 2000, 69(2), 113-118. doi: 10.1016/S0020-7292(00)00185-5 PMID: 10802078
  68. Proctor, M.L.; Murphy, P.A. Herbal and dietary therapies for primary and secondary dysmenorrhoea. Cochrane Database Syst. Rev., 2001, (3), CD002124. PMID: 11687013
  69. Ziaei, S.; Faghihzadeh, S.; Sohrabvand, F.; Lamyian, M.; Emamgholy, T. A randomised placebo-controlled trial to determine the effect of vitamin E in treatment of primary dysmenorrhoea. BJOG, 2001, 108(11), 1181-1183. doi: 10.1111/j.1471-0528.2003.00279.x PMID: 11762659
  70. Jahangirifar, M.; Taebi, M.; Dolatian, M. The effect of Cinnamon on primary dysmenorrhea: A randomized, double-blind clinical trial. Complement. Ther. Clin. Pract., 2018, 33(33), 56-60. doi: 10.1016/j.ctcp.2018.08.001 PMID: 30396627
  71. Vinodoni, R.; Hazel, A.A.; Sundaram, M.M.; Banumathi, V. Therapeutic potency of Siddha herbomineral preparation SiddhadhiEnnai on gynaecological diseases–a review. World J. Pharm. Pharm. Sci., 2018, 7(10), 969-979.
  72. Adib Rad, H.; Basirat, Z.; Bakouei, F.; Moghadamnia, A.A.; Khafri, S.; Farhadi Kotenaei, Z.; Nikpour, M.; Kazemi, S. Effect of Ginger and Novafen on menstrual pain: A cross-over trial. Taiwan. J. Obstet. Gynecol., 2018, 57(6), 806-809. doi: 10.1016/j.tjog.2018.10.006 PMID: 30545531
  73. Jose, B.; Jesy, E.J.; Nedumpara, R.J. Evaluation of the DPPH free radical scavenging activity of Wrightia tinctoria R. Br. leaf, bark and seed extracts. World J. Pharm. Res., 2014, 3(3), 5041-5048.
  74. Liao, J.; Deng, J.; Chiu, C.; Hou, W.; Huang, S.; Shie, P. Anti-inflammatory activities of cinnamomum cassia constituents In vitro and In vivo. Evid. Based Compl. Alter. Med., 2012, 2022, 1-12.
  75. Jeena, K.; Liju, V.B.; Kuttan, R. Antioxidant, anti-inflammatory and antinociceptive activities of essential oil from ginger. Indian J. Physiol. Pharmacol., 2013, 57(1), 51-62. PMID: 24020099
  76. Grzanna, R.; Lindmark, L.; Frondoza, C.G. Ginger--an herbal medicinal product with broad anti-inflammatory actions. J. Med. Food, 2005, 8(2), 125-132. doi: 10.1089/jmf.2005.8.125 PMID: 16117603
  77. Kumar, A.; Singh, A.K. Trachyspermum Ammi (Ajwain): A Comprehensive Review. World J. Pharm. Res., 2021, 10(6), 724-736.
  78. Umar, S.; Asif, M.; Sajad, M.; Ansari, M.M.; Hussain, U.; Ahmad, W.; Siddiqui, S.A.; Ahmad, S.; Khan, H.A. Anti-inflammatory and antioxidant activity of Trachyspermum ammi seeds in collagen induced arthritis in rats. Int. J. Drug Dev. & Res., 2012, 4(1), 210-219.
  79. Vaishnav, M.; Makim, R. Evaluation of Effect of Trachyspermum ammi Extract on Primary Dysmenorrhoea. Annals of R.S.C.B., 2020, 24(2), 1233-1237.
  80. Samadipour, E.; Rakhshani, M.H.; Kooshki, A.; Amin, B. Local Usage of Nigella sativa Oil as an Innovative Method to Attenuate Primary Dysmenorrhea: A Randomized Double-blind Clinical Trial. Oman Med. J., 2020, 35(5), e167. doi: 10.5001/omj.2020.109 PMID: 32953142
  81. Hajhashemi, V.; Ghannadi, A.; Jafarabadi, H. Black cumin seed essential oil, as a potent analgesic and antiinflammatory drug. Phytother. Res., 2004, 18(3), 195-199. doi: 10.1002/ptr.1390 PMID: 15103664
  82. Omidvar, S.; Esmailzadeh, S.; Baradaran, M.; Basirat, Z. Effect of fennel on pain intensity in dysmenorrhoea: A placebo-controlled trial. Ayu, 2012, 33(2), 311-313. doi: 10.4103/0974-8520.105259 PMID: 23559811
  83. Heidarifar, R.; Mehran, N.; Heidari, A.; Koohbor, M. Mansourabad, MK Effect of Dill Anethum graveolens on the severity of primary dysmenorrhea in compared with mefenamic acid: A randomized, double-blind trial. J res med sci., 2014, 19(4), 326.
  84. Kazemi, M. Phenolic profile, antioxidant capacity and anti-inflammatory activity of Anethum graveolens L. essential oil. Nat. Prod. Res., 2015, 29(6), 551-553. doi: 10.1080/14786419.2014.951934 PMID: 25154406
  85. Pundarikakshudu, K.; Shah, D.; Panchal, A.; Bhavsar, G. Anti-inflammatory activity of fenugreek (Trigonella foenum-graecum Linn) seed petroleum ether extract. Indian J. Pharmacol., 2016, 48(4), 441-444. doi: 10.4103/0253-7613.186195 PMID: 27756958
  86. Younesy, S.; Amiraliakbari, S.; Esmaeili, S.; Alavimajd, H.; Nouraei, S. Effects of fenugreek seed on the severity and systemic symptoms of dysmenorrhea. J. Reprod. Infertil., 2014, 15(1), 41-48. PMID: 24695380
  87. K, A.; Sultana, A.; Rahman, K. A single-blind randomized comparative study of Asafoetida vs Mefenamic acid in dysmenorrhea, associated symptoms and health-related quality of life. J. Herb. Med., 2017, 9, 21-31. doi: 10.1016/j.hermed.2017.06.003
  88. Bagheri, S.M.; Hedesh, S.T.; Mirjalili, A.; Dashti-R, M.H. Evaluation of anti-inflammatory and some possible mechanisms of antinociceptive effect of Ferula assa foetida oleo gum resin. J. Evid. Based Complementary Altern. Med., 2016, 21(4), 271-276. doi: 10.1177/2156587215605903 PMID: 26427790
  89. Nazari, M.; Rostami-Moez, M.; Ebrahimi, F. The effect of fennel on pain relief in primary dysmenorrhea: A systematic review of clinical trials. Int. J. Epidemiol. Res., 2020, 7(1), 44-48. doi: 10.34172/ijer.2020.08
  90. Ostad, S.N.; Soodi, M.; Shariffzadeh, M.; Khorshidi, N.; Marzban, H. The effect of fennel essential oil on uterine contraction as a model for dysmenorrhea, pharmacology and toxicology study. J. Ethnopharmacol., 2001, 76(3), 299-304. doi: 10.1016/S0378-8741(01)00249-5 PMID: 11448553
  91. Amirsalari, S.; Behboodi Moghadam, Z.; Taghizadeh, Z.; Jafar Abadi, M.N.; Sabaghzadeh Irani, P.; Goodarzi, S.; Ranjbar, H. The effect of garlic tablets on the endometriosis-related pains: a randomized placebo-controlled clinical trial. Evid. Based Complement. Alternat. Med., 2021, 2021, 1-8. doi: 10.1155/2021/5547058 PMID: 34335819
  92. Jayanthi, M.K.; Dhar, M.; Jayanthi, M. Anti-inflammatory effects of Allium sativum (garlic) in experimental rats. Biomedicine (Taipei), 2011, 31(1), 84-89.
  93. Bahrami, A.; Zarban, A.; Rezapour, H.; Agha Amini Fashami, A.; Ferns, G.A. Effects of curcumin on menstrual pattern, premenstrual syndrome, and dysmenorrhea: A triple‐blind, placebo‐controlled clinical trial. Phytother. Res., 2021, 35(12), 6954-6962. doi: 10.1002/ptr.7314 PMID: 34708460

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1. JATS XML

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