电邮这篇文章 STUDY OF THE EFFECTIVENESS OF RECOMBINANT PLASMIDS IN A NEUROPATHY MODEL AT POISONING WITH MALATHION
- 作者: Shilov V.V.1, Judin M.A.2, Shherbakov T.V.1, Belichenko O.A.1
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隶属关系:
- Northwest Scientific Center of Hygiene and Public Health
- Scientific Research Test Institute of Military Medicine, S.M. Kirov Medical Military Academy
- 期: 编号 4 (2015)
- 页面: 26-30
- 栏目: Articles
- ##submission.datePublished##: 30.08.2015
- URL: https://rjsocmed.com/0869-7922/article/view/641342
- DOI: https://doi.org/10.15690/vramn499
- ID: 641342
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详细
The effectiveness of gene therapy agents application, i.e.: recombinant plasmid DNA (RPD) coding body growth factor production (nerve growth factor (NGF), vascular endothelial growth factor (VEGF) and somatoliberin-1) was shown using a model of peripheral neuropathy caused by a thrice-repeated 0.5 LD50 malathion injection to rats. RPD NGF and RPD VEGF were found to have the strongest nerve tissue protective effect. According to electrophysiological studies findings, the preparations based on these plasmid constructions exerted a positive effect as early as a week after the damage and completely removed neuropathy manifestations by the 21 day.
作者简介
Viktor Shilov
Northwest Scientific Center of Hygiene and Public Health
编辑信件的主要联系方式.
Email: noemail@neicon.ru
Доктор медицинских наук, профессор, директор ФБУН «Северо-Западный научный центр гигиены и общественного здоровья» Роспотребнадзора, 191036, г. Санкт-Петербург, Российская Федерация
e-mail: vshilov@inbox.ru
俄罗斯联邦Mikhail Judin
Scientific Research Test Institute of Military Medicine, S.M. Kirov Medical Military Academy
Email: noemail@neicon.ru
Доцент кандидат медицинских наук заместитель начальника отдела Научно-исследовательского испытательного института военной медицины Военно-медицинской академии имени С.М. Кирова, 195043, г. Санкт-Петербург, Российская Федерация,
e-mail: mikhail.judin@gmail.com
俄罗斯联邦Taras Shherbakov
Northwest Scientific Center of Hygiene and Public Health
Email: noemail@neicon.ru
Аспирант ФБУН «Северо-Западный научный центр гигиены и общественного здоровья» Роспотребнадзора, 191036, г. Санкт-Петербург, Российская Федерация
e-mail: taraskbr@yandex.ru
俄罗斯联邦Olga Belichenko
Northwest Scientific Center of Hygiene and Public Health
Email: noemail@neicon.ru
Лаборант-исследователь лаборатории токсикологии ФБУН «Северо-Западный научный центр гигиены и общественного здоровья» Роспотребнадзора, 191036, г. Санкт-Петербург, Российская Федерация
e-mail: sznc.viv@gmail.com
俄罗斯联邦参考
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