电邮这篇文章 INFLUENCE OF POTASSIUM BICHROMATE ON MORPHOLOGICAL AND IMMUNOLOGICAL CHARACTERISTICS OF WISTAR RATS
- 作者: Smolyagin A.I.1, Mikhaylova I.V.1, Ermolina E.V.1, Stadnikov A.A.1, Boev V.M.1
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隶属关系:
- State Budgetary Educational Institution «Orenburg State Medical Academy», Ministry of Health of Russia
- 期: 编号 2 (2015)
- 页面: 40-44
- 栏目: Articles
- ##submission.datePublished##: 06.04.2015
- URL: https://rjsocmed.com/0869-7922/article/view/641321
- DOI: https://doi.org/10.15690/vramn448
- ID: 641321
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The impact of Potassium Bichromate ( at 1 MAC dose) on morphological and immunological parameters of Wistar rats lymphoid organs was investigated in a chronic experiment (135 days). A lasting uptake of chromium by the Wistar rat organism induces a decrease of thymus mass and thymocytes number, causes a complex of structural and functional alterations evidencing about the status of accidental involution, lymphoreticular hyperplasia and plasmocytic and macrophage transformation of lymphoid nodes and spleen, induces a programmed death of thymocytes and lymphocytes in splenic T-zones and lymphoid nodes. Chromium induces morpho-functional changes in spleen shown by decrease in its weight and number of spelnocytes, lymphoid series cells and on the contrary by increase of erythroid series cells. The impact of chromium on the bone marrow was evident in a decreased level of myeloid series, neutrophils and on the contrary in increased amount of lymphoid cells and the content of erythroid cells as well.
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作者简介
Aleksandr Smolyagin
State Budgetary Educational Institution «Orenburg State Medical Academy», Ministry of Health of Russia
编辑信件的主要联系方式.
Email: noemail@neicon.ru
Доктор медицинских наук, профессор, заведующий проблемной лабораторией по изучению механизмов естественного иммунитета Оренбургской государственной медицинской академии Минздрава РФ, 460000, г. Оренбург
e-mail: probllab.orenburg@mail.ru
俄罗斯联邦Irina Mikhaylova
State Budgetary Educational Institution «Orenburg State Medical Academy», Ministry of Health of Russia
Email: noemail@neicon.ru
Доктор биологических наук, доцент кафедры химии и фармацевтической химии Оренбургской государственной медицинской академии Минздрава РФ, 460000, г. Оренбург
e-mail: michaylova74@yandex.ru
俄罗斯联邦Evgenija Ermolina
State Budgetary Educational Institution «Orenburg State Medical Academy», Ministry of Health of Russia
Email: noemail@neicon.ru
Кандидат биологических наук, старший научный сотрудник проблемной лаборатории по изучению механизмов естественного иммунитета Оренбургской государственной медицинской академии Минздрава РФ, 460000, г. Оренбург
e-mail: probllab.orenburg@mail.ru
俄罗斯联邦Aleksandr Stadnikov
State Budgetary Educational Institution «Orenburg State Medical Academy», Ministry of Health of Russia
Email: noemail@neicon.ru
Доктор биологических наук, профессор, заведующий кафедрой гистологии, цитологии эмбриологии, 460000, г. Оренбург
e-mail: k_histology@orgma.ru
俄罗斯联邦Viktor Boev
State Budgetary Educational Institution «Orenburg State Medical Academy», Ministry of Health of Russia
Email: noemail@neicon.ru
Доктор медицинских наук, профессор, ректор Оренбургской государственной медицинской академии Минздрава РФ, 460000, г. Оренбург
e-mail: probllab.orenburg@mail.ru
俄罗斯联邦参考
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- GN 2.1.5.2280-07. Maximum permissible concentration (MPC) of chemicals in water of the economydrinking and cultural-everyday objects. Moscow : Rospotrebnadzor; 2008 (in Russian).
- Kiyasov A.P. Modern technology of the morphological studies: Toolkit for students, post-graduate and doctors-pathologists. Kazan’: KGMU; 2001 (in Russian).
- Volchegorsky I.A., Dolgushin I.I., Kolesnikov O.L., Cejlikman V.Je. Experimental modeling and laboratory evaluation of the adaptive reactions. Cheljabinsk: ChGPU; 2000 (in Russian).
- Yarilin A.A. Immunology. Moscow: GEOTAR-Media; 2010 (in Russian).
- Kurlyandskiy B.A., Filov V.A., red. General Toxicology. Moscow: Meditsina; 2002 (in Russian).
- O’Brien, P., Kortenkamp A. Chemical models important in understanding the ways in which chromate can damage DNA. Environ Health Perspect. 1994; 102 (3): 3-10.
- Iztleutov M.K. Patogenez of violations of the homeostasis caused by excess intake of chrome in an organism, and ways of their correction: Dr. med. sci. diss. Moscow ; 2004 (in Russian).
- Valko M., Morris H., Cronin M. T. Metals, toxicity and oxidative stress. Curr. Med. Chem. 2005; 12:1161-1208.
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