电邮这篇文章 EXPERIMENTAL EVALUATION OF TOXICOMETRIC INDICATORS AND ANALGESIC ACTIVITY OF KAPPA-OPIOID RECEPTOR AGONISTS
- 作者: Chepur S.V.1, Galan S.E.1, Vakhviayanen M.S.1, Khromov R.N.1, Semenov A.N.1
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隶属关系:
- State Scientific Research Testing Institute of Military Medicine, Ministry of Defence of the Russian Federation
- 期: 编号 4 (2020)
- 页面: 27-33
- 栏目: Articles
- ##submission.datePublished##: 31.07.2020
- URL: https://rjsocmed.com/0869-7922/article/view/641248
- DOI: https://doi.org/10.36946/0869-7922-2020-4-27-33
- ID: 641248
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详细
Data on the biological activity of kappa-opioid receptor agonists - derivatives of three groups of compounds: 1,2-cyclohexylamine, 1,2,3,4-piperidine, 1,2,4-piperazine are presented. On the examples of 1,2-cyclohexylamine and 1,2,4-piperazine derivatives, it has been shown that a decrease in the length of the carbon chain in the phenylalkyl substituent at the nitrogen atom is accompanied by a decrease in the analgesic activity and toxicity of compounds. The replacement of chlorine atoms in the 3 and 4 positions of the phenyl ring with fluorine atoms, which are more electronegative, leads to an increase in the analgesic effect and a decrease in the toxicity of the compounds.
作者简介
S. Chepur
State Scientific Research Testing Institute of Military Medicine, Ministry of Defence of the Russian Federation
编辑信件的主要联系方式.
Email: gniiivm_15@mil.ru
Chepur Sergei Viktorovich
195043, Saint Petersburg
俄罗斯联邦S. Galan
State Scientific Research Testing Institute of Military Medicine, Ministry of Defence of the Russian Federation
Email: gniiivm_15@mil.ru
Galan Sergei Evgenievich
195043, Saint Petersburg
俄罗斯联邦M. Vakhviayanen
State Scientific Research Testing Institute of Military Medicine, Ministry of Defence of the Russian Federation
Email: gniiivm_15@mil.ru
Vakhviayanen Maria Sergeevna
195043, Saint Petersburg
俄罗斯联邦R. Khromov
State Scientific Research Testing Institute of Military Medicine, Ministry of Defence of the Russian Federation
Email: gniiivm_15@mil.ru
Khromov Roman Nikolaevich
195043, Saint Petersburg
俄罗斯联邦A. Semenov
State Scientific Research Testing Institute of Military Medicine, Ministry of Defence of the Russian Federation
Email: gniiivm_15@mil.ru
Semenov Alexander Nikolaevich
195043, Saint Petersburg
俄罗斯联邦参考
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