INTERRELATION OF PLATINUM ELECTRODE OPEN CIRCUIT POTENTIAL IN THE BLOOD PLASMA AND OXIDATIVE STRESS COEFFICIENT IN PATIENTS WITH ACUTE POISONING BY CAUTERANT AGENTS

The relationship between the platinum electrode open circuit potential (OCP) in the blood plasma as an integral indicator of the balance of oxidation-reduction processes in the body with an oxidative stress coefficient (K) reflecting the balance of the lipid peroxidation and state of antioxidant system (LPO/AOS) in patients with acute poisoning by cauterant agents was investigated. The platinum electrode OCP in the blood plasma was measured using an original electrochemical technique. The oxidative stress coefficient was determined from the ratio of the malondialdehyde level to the total antioxidant activity of blood serum. The shift of the value of the platinum electrode OCP in blood plasma during the first 5-7 days towards the positive potential region coincided with the intensification of LPO processes and the decrease in total antioxidant activity of the blood serum. Sharp shift in the value of the platinum electrode OCP to the region of positive values (more than 25 mV) in patients with acute poisoning with cauterant agents coincides with the worsening of their condition. The data obtained during the monitoring of the platinum electrode OCP in blood plasma in patients with acute poisoning by cauterant agents allow to make a conclusion about the diagnostic capabilities of this technique for assessing the patient’s severity and correcting his treatment.

open circuit potential, oxidative stress, electrode, blood plasma, malondialdehyde, total antioxidant activity, acute poisoning, cauterant agents