EFFECTIVENESS PROGNOSTICATION OF A COMBINED ANALGESIC FORMULATION DEPENDING ON QUANTITATIVE COMPOSITION OF ITS COMPONENTS

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In experiments on rats, analgesic activity of fentanyl opioid receptor agonist and central 2-adrenomimetic dexmedetomidine as well as the character of their interaction at a combined administration were studied. Meaneffective anesthetic doses of the drugs in heat radiant tail flick test were 54.5 and 22.5 μg/kg correspondingly. Using izobolographic analysis, it was shown that for a combination with equal parts or with a greater part of fentanyl, the type of drug interaction can be characterized as potentiation. A model of prognostication of probability values of the analgesic effect development in relation to doses of combination components was elaborated and experimentally tested.

Sobre autores

N. Vengerovich

State Research and Test Institute of Military Medicine, RF Ministry of Defense

Autor responsável pela correspondência
Email: noemail@neicon.ru
195043, Saint Petersburg Rússia

M. Yudin

State Research and Test Institute of Military Medicine, RF Ministry of Defense

Email: noemail@neicon.ru
195043, Saint Petersburg Rússia

A. Nikiforov

State Research and Test Institute of Military Medicine, RF Ministry of Defense

Email: noemail@neicon.ru
195043, Saint Petersburg Rússia

G. Sagalov

S.M. Kirov Medical Military Academy, RF Ministry of Defense

Email: noemail@neicon.ru
194044, Saint Petersburg Rússia

M. Vakhviyainen

Innovative pharmaceutical company “Silver Pharm” Ltd

Email: noemail@neicon.ru
195279, Saint Petersburg Rússia

A. Kuzmin

State Research and Test Institute of Military Medicine, RF Ministry of Defense

Email: noemail@neicon.ru
195043, Saint Petersburg Rússia

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Declaração de direitos autorais © Vengerovich N.G., Yudin M.A., Nikiforov A.S., Sagalov G.S., Vakhviyainen M.S., Kuzmin A.A., 2016


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