Analysis of promising directions for improving the methodological part of the biological monitoring system at potentially hazardous chemical facilities (analytical review)

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Abstract

Introduction. Currently in the Russian Federation, the practice of industrial medicine does not use methods of biological monitoring of organic compounds — an addition to industrial control, which consists in regularly measuring the content of biomarkers of harmful chemicals in the body of workers.

The purpose of the study is to analyze available scientific publications and methodological documents on biomarkers of harmful organic substances, to draw conclusions about the directions for the development of methodological support for biological monitoring of organic compounds in the Russian Federation.

Material and methods. available scientific publications, methodological guidelines of Rospotrebnadzor, materials of the Russian Register of Potentially Hazardous Chemical and Biological Substances, and foreign methodological documents, in particular from the Agency for Toxic Substances and Disease Registry, USA, were used.

Results. A list of the most common harmful organic substances circulating at hazardous chemical facilities, their biomarkers and methods for measuring them in biological media was compiled. An analysis of domestic and foreign hygienic standards for the content of toxicants or their markers in biological media was performed.

Limitations. The analytical review of biological monitoring methods was carried out only for organic compounds and does not include inorganic substances.

Conclusion. The analytical review made it possible to identify the following necessary methodological elements for the implementation of biological monitoring in the Russian Federation: the development of at least 9 chemical-analytical methods for determining biomarkers in the biological environments of workers, the introduction of immunochromatographic methods when conducting biological monitoring of workers to clarify the reliability of anamnesis data on attitudes towards alcohol, smoking and medications, experimental studies on the detection and identification of biomarkers of exposure to a number of organic compounds, experimental substantiation of hygienic standards for the content of 15 substances in the air of the working area.

Compliance with ethical standards. The study does not require the submission of a biomedical ethics report.

Authors contribution:
Ukolov A.I. — concept, collection and processing of material, writing text;
Kombarova M.Yu. — collection and processing of material;
Reynyuk V.L., Barinov V.A., Radilov A.S. — editing.
All co-authors — approval of the final version of the article, responsibility for the integrity of all parts of the article.

Conflict of interest. The authors declare no conflict of interest

Financing. The study had no sponsorship.

Received: December 12, 2023 / Accepted: May 5, 2024 / Published: June 28, 2024

About the authors

Anton I. Ukolov

Federal State Unitary Enterprise “Research Institute of Hygiene, Occupational Pathology and Human Ecology” FMBA of Russia; Federal State Budgetary Institution “Scientific and Clinical Center of Toxicology named after Academician S.N. Golikov of the FMBA of Russia”

Author for correspondence.
Email: AntonUkolov@gmail.com
ORCID iD: 0000-0002-2911-1260

Candidate of Chemical Sciences, Head of the Department of Toxicology of the Federal State Unitary Enterprise «Research Institute of Hygiene, Occupational Pathology and Human Ecology» FMBA of Russia, 188663, Leningrad Region, Russian Federation

e-mail: AntonUkolov@gmail.com

Scopus Author ID: 25321116600

Researcher ID: S-2545-2016

Russian Federation

Mariia Yu. Kombarova

Federal State Unitary Enterprise “Research Institute of Hygiene, Occupational Pathology and Human Ecology” FMBA of Russia

Email: Kombarova@gpech.ru
ORCID iD: 0000-0003-0435-3228

Candidate of Medical Sciences, Head of the Department of Hygiene, of the Federal State Unitary Enterprise “Research Institute of Hygiene, Occupational Pathology and Human Ecology” FMBA of Russia, 188663, Leningrad Region, Russian Federation

e-mail: Kombarova@gpech.ru

Russian Federation

Vladimir L. Reiniuk

Federal State Budgetary Institution “Scientific and Clinical Center of Toxicology named after Academician S.N. Golikov of the FMBA of Russia”

Email: info@toxicology.ru
ORCID iD: 0000-0002-4472-6546

Doctor of Medical Sciences, Professor, Acting Director of the Federal State Budgetary Institution “Scientific and Clinical Center of Toxicology named after Academician S.N. Golikov of the FMBA of Russia”, 192019, St. Petersburg, Russian Federation

e-mail: info@toxicology.ru

SPIN-code: 5828-0337

Author ID: 162221

Scopus ID 9844286100

Russian Federation

Vladimir A. Barinov

Federal State Budgetary Institution “Scientific and Clinical Center of Toxicology named after Academician S.N. Golikov of the FMBA of Russia”

Email: dissovet@toxicology.ru
ORCID iD: 0000-0002-3276-8036

Doctor of Medical Sciences, Leading researcher of Federal State Budgetary Institution “Scientific and Clinical Center of Toxicology named after Academician S.N. Golikov of the FMBA of Russia”, 192019, St. Petersburg, Russian Federation

e-mail: dissovet@toxicology.ru

SPIN-код: 3434-6341

Author ID: 788870

Scopus ID: 57191163581

Russian Federation

Andrey S. Radilov

Federal State Unitary Enterprise “Research Institute of Hygiene, Occupational Pathology and Human Ecology” FMBA of Russia

Email: radilov@gpech.ru
ORCID iD: 0000-0003-0776-7434

Doctor of Medical Sciences, Professor, Acting Director of the Federal State Unitary Enterprise «Research Institute of Hygiene, Occupational Pathology and Human Ecology» FMBA of Russia, 188663, Leningrad Region, Russian Federation

E-mail: radilov@gpech.ru

SPIN-code: 2081-5320

Author ID: 631675

Scopus ID 6507193049

Russian Federation

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