Email this article Research of the alginate-pectin sorbent influence on the elimination of cadmium from the body of rats
- Authors: Shemaev M.E.1, Malov A.M.1, Glushkov R.K.1, Krasnov K.A.1, Shchegolihin D.K.1, Lapina N.V.1
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Affiliations:
- Federal State budgetary institution «Scientific and Clinical Center of Toxicology named after Academician S.N. Golikov Federal Medical and Biological Agency»
- Issue: No 1 (2023)
- Pages: 24-29
- Section: Original articles
- Published: 23.02.2023
- URL: https://rjsocmed.com/0869-7922/article/view/641477
- DOI: https://doi.org/10.47470/0869-7922-2023-31-1-24-29
- ID: 641477
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Abstract
Introduction. Heavy metals have a serious toxic effect on the human body. The availability of adequate models for the elimination of toxicants and the testing of enterosorbents based on them will improve the quality of poisoning therapy.
Material and methods. To assess the effectiveness of the sorbent, a formalized model based on data on the cumulative excretion of cadmium in urine and feces for 20 days was used. Intramuscular priming with cadmium acetate was carried out during the first three days of the experiment at a daily dose of 3 mg/ kg, the enterosorbent was administered orally at a dose of 100 mg/kg during the study. The cadmium content in the biological media was determined by methods of inversion voltammetry.
Results. During the experiment, no more than 3% of the injected toxicant was removed from the animals of both groups. The enterosorbent in the conditions of the experiment did not change the amount of cadmium excreted, but affected the redistribution between the renal and intestinal elimination streams. A significant effect of the enterosorbent on the cadmium content in the liver was noted.
Limitations. Evaluation of the effect of the drug on the elimination of the toxicant was carried out for a limited period of time. Additional experiments with longer observation periods and other metals and their dosages would allow to reveal in more detail the beneficial properties of the studied drug.
Conclusion. A significant effect of the enterosorbent on the cadmium content in the liver was noted. There may be a secondary intake of cadmium into the blood from the intestine and a negative effect of this process on kidneys.
Compliance with ethical standards. The study was carried out according to the principles of humanity set out in the Directive of the European Parliament and of the Council of the European Union (2010/63/EU).
Author contribution. All co-authors made an equal contribution to the research and preparation of the article for publication.
Conflict of interest. The authors declare no conflict of interest
Acknowledgments. The study was carried out within the framework of the state task of Federal State budgetary institution «Scientific and Clinical Center of Toxicology named after Academician S. N. Golikov Federal Medical and Biological Agency».
Received: July 1, 2022 / Accepted: January 2023 / Published: February 28, 2023
Keywords
About the authors
Mikhail Evgen’evich Shemaev
Federal State budgetary institution «Scientific and Clinical Center of Toxicology named after Academician S.N. Golikov Federal Medical and Biological Agency»
Author for correspondence.
Email: shemaevm@mail.ru
ORCID iD: 0000-0001-6062-0437
Junior Researcher of Federal State budgetary institution «Scientific and Clinical Center of Toxicology named after Academician S.N. Golikov Federal Medical and Biological Agency», 192019, St. Petersburg, Russian Federation.
e-mail: shemaevm@mail.ru
Russian FederationAlexandr Mikhajlovich Malov
Federal State budgetary institution «Scientific and Clinical Center of Toxicology named after Academician S.N. Golikov Federal Medical and Biological Agency»
Email: malexmish@rambler.ru
Кандидат биол. наук, ведущий научный сотрудник ФГБУ НКЦТ им. С.Н. Голикова ФМБА России, 192019, Санкт-Петербург, Российская Федерация.
e-mail: malexmish@rambler.ru
Russian FederationRudol’f Konstantinovich Glushkov
Federal State budgetary institution «Scientific and Clinical Center of Toxicology named after Academician S.N. Golikov Federal Medical and Biological Agency»
Email: institute@toxicology.ru
Кандидат хим. наук, химик-эксперт ФГБУ НКЦТ им. С.Н. Голикова ФМБА России, 192019, Санкт-Петербург, Российская Федерация.
e-mail: institute@toxicology.ru
Russian FederationKonstantin Andreevich Krasnov
Federal State budgetary institution «Scientific and Clinical Center of Toxicology named after Academician S.N. Golikov Federal Medical and Biological Agency»
Email: krasnov_tox@mail.ru
Кандидат хим. наук, ведущий научный сотрудник ФГБУ НКЦТ им. С.Н. Голикова ФМБА России, 192019, Санкт-Петербург, Российская Федерация.
e-mail: krasnov_tox@mail.ru
Russian FederationDmitrij Konstantinovich Shchegolihin
Federal State budgetary institution «Scientific and Clinical Center of Toxicology named after Academician S.N. Golikov Federal Medical and Biological Agency»
Email: shchegolihind@gmail.com
Младший научный сотрудник ФГБУ НКЦТ им. С.Н. Голикова ФМБА России, 192019, Санкт-Петербург, Российская Федерация.
e-mail: shchegolihind@gmail.com
Russian FederationNatalia Vadimovna Lapina
Federal State budgetary institution «Scientific and Clinical Center of Toxicology named after Academician S.N. Golikov Federal Medical and Biological Agency»
Email: lapina2005@inbox.ru
Кандидат мед. наук, заведующий отделом токсикологии ФГБУ НКЦТ им. С.Н. Голикова ФМБА России, 192019, Санкт-Петербург, Российская Федерация.
e-mail: lapina2005@inbox.ru
Russian FederationReferences
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