Association of glutathione-S-transferase gene polymorphisms with various disease (review of foreign studies)

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Abstract

Introduction. This review is devoted to the association of GSTM1, GSTT1, GSTP1 gene polymorphisms with various diseases in foreign literature sources.

Material and methods. For this article, we used data published in foreign literature over the past 11 years. medline was extensively searched for eligible studies using the Pubmed search engine, and 30 studies were eventually selected for inclusion in this review.

Results. This review showed that researchers all over the world have repeatedly tried to evaluate the relationship between GST polymorphisms and various diseases, but in some cases received conflicting results. At the same time, many studies have found an association of pathologies with both single GST gene polymorphisms and combined polymorphic variants, which indicates a complex effect of antioxidant system genes.

Limitation of the study. The limitation of this review is the lack of domestic literary sources.

Conclusion. Further research of functional polymorphisms of the GST family genes are needed to develop effective systems for the diagnosis, prevention, and treatment of diseases.

Compliance with ethical standards. This study does not require the conclusion of a biomedical ethics committee or other documents.

Contribution. All co-authors made an equal contribution to the research and preparation of the article for publication.

Conflict of interests. The authors declare no conflict of interest.

Funding. The study had no sponsorship.

Received: January 1, 2023 / Accepted: February 2, 2023 / Published: April 30, 2023

About the authors

Ivan Andreevich Bereza

Yekaterinburg Medical and Scientific Center for Prevention and Health Protection of Industrial Workers of the Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Author for correspondence.
Email: berezaia@ymrc.ru
ORCID iD: 0000-0002-4109-9268

Researcher, Department of Molecular Biology and Electron Microscopy, FBRI YMRC PHPIW of Rospotrebnadzor, 620014, Yekaterinburg, Russian Federation.

e-mail: ivan11011994@gmail.com

Russian Federation

Daria Ramilevna Shaikhova

Yekaterinburg Medical and Scientific Center for Prevention and Health Protection of Industrial Workers of the Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: darya.boo@mail.ru
ORCID iD: 0000-0002-7029-3406
Russian Federation

Anna Mikhailovna Amromina

Yekaterinburg Medical and Scientific Center for Prevention and Health Protection of Industrial Workers of the Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: amrominaam@ymrc.ru
ORCID iD: 0000-0001-8794-7288
Russian Federation

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