ASSOCIATION OF BCHE GENE POLYMORPHIC VARIANTS WITH BUTYRYLCHOLINESTERASE ACTIVITY IN RATS POISONED WITH MALATHION

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Abstract

The association of Bche gene polymorphisms with butyrylcholinesterase activity was investigated on a model of rats poisoned with malathion at a dose of 1 LD50. The genotype distribution of six polymorphic variants of Bche gene was studied. An authentic association (p C (SNPID rs198598583), G>T (SNPID rs106118718), A>T (SNPID rs107226860) with butyrylcholinesterase activity in the liver tissue a day after poisoning was shown; the prevalence of those polymorphic variants is associated with linked type of inheritance. The highest linkage correlation of the enzyme activity in the liver was observed in variants A>T (rs107226860) and G>T (rs106118718). Enzyme activity in rats with a homozygous genotype was authentically higher ( by 30%) compared to the heterozygous genotype.

About the authors

Aleksandr Vladimirovich Babkin

Scientific Research Test Institute of Military Medicine, S.M. Kirov Medical Military Academy

Author for correspondence.
Email: noemail@neicon.ru

Научный сотрудник НИИИ ВМ ВМедА им. С.М. Кирова Министерства обороны Российской Федерации, 195043, г. Санкт-Петербург

e-mail: babkinnik@yandex.ru

Russian Federation

Irina Sergeevna Berdinskih

Scientific Research Test Institute of Military Medicine, S.M. Kirov Medical Military Academy

Email: noemail@neicon.ru

Научный сотрудник НИИИ ВМ ВМедА им. С.М. Кирова Министерства обороны Российской Федерации, 195043, г. Санкт-Петербург

e-mail: irina_berdinskih@mail.ru

Russian Federation

Natalya Sergeevna Osechkina

Scientific Research Test Institute of Military Medicine, S.M. Kirov Medical Military Academy

Email: noemail@neicon.ru

Младший научный сотрудник НИИИ ВМ ВМедА им. С.М. Кирова Министерства обороны Российской Федерации, 195043, г. Санкт-Петербург

e-mail: dunats@rambler.ru

Russian Federation

Georgiy Valerevich Nazarov

Scientific Research Test Institute of Military Medicine, S.M. Kirov Medical Military Academy

Email: noemail@neicon.ru

Доктор химических наук, доцент, начальник отдела НИИИ ВМ ВМедА им. С.М. Кирова Министерства обороны Российской Федерации, 195043, г. Санкт-Петербург,

e-mail: denis-100@list.ru

Russian Federation

Mikhail Anatol’evich Judin

Scientific Research Test Institute of Military Medicine, S.M. Kirov Medical Military Academy

Email: noemail@neicon.ru

Кандидат медицинских наук, доцент, заместитель начальника отдела НИИИ ВМ ВМедА им. С.М. Кирова Министерства обороны Российской Федерации, 195043, г. Санкт-Петербург

e-mail: mikhail.judin@gmail.com

Russian Federation

Vladimir Nikolaevich Bykov

Scientific Research Test Institute of Military Medicine, S.M. Kirov Medical Military Academy

Email: noemail@neicon.ru

Доктор медицинских наук, доцент, начальник центра НИИИ ВМ ВМедА им. С.М. Кирова Министерства обороны Российской Федерации, 195043, г. Санкт-Петербург

e-mail: bykov_imm@yahoo.com

Russian Federation

Andrey Mikhailovich Sarana

City Hospital № 40

Email: noemail@neicon.ru

Кандидат медицинских наук, доцент, начальник отделения реабилитации СПб ГБУЗ «Городская больница № 40», г. Сестрорецк, 197706, г. Санкт-Петербург

Russian Federation

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Copyright (c) 2014 Babkin A.V., Berdinskih I.S., Osechkina N.S., Nazarov G.V., Judin M.A., Bykov V.N., Sarana A.M.


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