Email this article FEATURES OF TOXIC EFFECT OF 5-AMINOLEVULINIC ACID HEXYL ESTER AT SINGLE AND MULTIPLE INTRAGASTRIC ADMINISTRATIONS
- Authors: Vlasenko E.K.1, Sychik S.I.1, Stelmakh V.A.1, Grynchak V.A.1
-
Affiliations:
- Republican Unitary Enterprise «Scientific and Practical Center of Hygiene», Ministry of Health of the Republic of Belarus
- Issue: No 5 (2015)
- Pages: 31-36
- Section: Articles
- Published: 01.10.2015
- URL: https://rjsocmed.com/0869-7922/article/view/641348
- DOI: https://doi.org/10.15690/vramn512
- ID: 641348
Cite item
Full Text
Abstract
In experiments on laboratory rats and mice, features of toxic effect of a promising plant growth regulator 5-aminolevulinic acid hexyl ester (ALA-HE) were investigated under conditions of single and multiple intra gastric administration. At single intra gastric administration, a median lethal dose of ALA-HE (LD50ac ) is 3000 mg/kg for mice (males) and 7800 mg/kg for rats (females), specific resistivity is not expressed (EHF<3).The threshold of acute effect Limac of 73 mg/kgwas established at the level of median effective dose ED50 (mice) . The cumulation coefficient obtained according to Lim et al method in experiments on mice makes 6.1. In experiments on rats according to Yu.S. Kagan and V.V. Stankevich method, the value of the cumulation coefficient was 1.6 at exposure to 1/5-fold of LD50. As a maximum tolerated dose, the value of 440 mg/kg (1/20 of LD50) was adopted.
About the authors
Evgenij Konstantinovich Vlasenko
Republican Unitary Enterprise «Scientific and Practical Center of Hygiene», Ministry of Health of the Republic of Belarus
Author for correspondence.
Email: noemail@neicon.ru
Научный сотрудник лаборатории профилактической и экологической токсикологии Республиканского унитарного предприятия «Научно-практический центр гигиены», Министерство здравоохранения Республики Беларусь, 220012, г. Минск, Республика Беларусь
e-mail: evgenii_vlasenko@mail.ru
Russian FederationSergej Ivanovich Sychik
Republican Unitary Enterprise «Scientific and Practical Center of Hygiene», Ministry of Health of the Republic of Belarus
Email: noemail@neicon.ru
Кандидат медицинских наук, доцент, директор Республиканского унитарного предприятия «Научно-практический центр гигиены», Министерство здравоохранения Республики Беларусь, 220012, г. Минск, Республика Беларусь
e-mail: rspch@rspch.by
Russian FederationViktor Aleksandrovich Stelmakh
Republican Unitary Enterprise «Scientific and Practical Center of Hygiene», Ministry of Health of the Republic of Belarus
Email: noemail@neicon.ru
Кандидат медицинских наук, доцент, ведущий научный сотрудник лаборатории профилактической и экологической токсикологии Республиканского унитарного предприятия «Научно-практический центр гигиены», Министерство здравоохранения Республики Беларусь, 220012, г. Минск, Республика Беларусь
e-mail: stelmakh2@gmail.com
Russian FederationVitali Aleksandrovich Grynchak
Republican Unitary Enterprise «Scientific and Practical Center of Hygiene», Ministry of Health of the Republic of Belarus
Email: noemail@neicon.ru
Младший научный сотрудник лаборатории профилактической и экологической токсикологии Республиканского унитарного предприятия «Научно-практический центр гигиены», Министерство здравоохранения Республики Беларусь, 220012, г. Минск, Республика Беларусь
e-mail: grinchakva@gmail.com
Russian FederationReferences
- Trostyanko I.V., Dolgopalets V.I., Kisel’ M.A., Lakhvich F.A. A process for preparing hydrochloride hexyl ester of 5-aminolevulinic acid. Patent RB, N 16176; 27.04.2012 (in Russian).
- Spivak S.G., Yaronskaya E.B., Vershilovskaya I.V., Davydov V.Yu., Trostyanko I.V., Dolgopalets V.I. The stimulation of plant growth and development of barley lipophilic esters of 5-aminolevulinic acid. Dokl. Nat. Acad. Sciences of Belarus. 2007; V. 51, 5: 9599 (in Russian).
- Edinye sanitarno-epidemiologicheskie i gigienicheskie trebovaniya k tovaram, podlezhashchim sanitarno-epidemiologicheskomu nadzoru (kontrolyu), utv. Resheniem Komissii tamozhennogo soyuza ot 28 maya 2010 goda № 299 (Glava II; Razdel 15. Trebovaniya k pestitsidam i agrokhimikatam) (in Russian).
- Guide for the care and use of laboratory animals. Institute of laboratory animal resourcens commission on life sciences research council. National academy press. Washington, D.C., 1996; 1-128.
- Belen’kiy, M.L. Elements of quantitative assessment of pharmacological effect. Riga; Izd-vo Akad.nauk Latv.SSR, 195: 115 (in Russian).
- Lim R. K., Rink K. G., Glass H. G., Soaje-Echague E. A method for the evaluation of cumulation and tolerance by the determination of acute and subchronic median effective doses. Arch. Int. Pharmacodyn. Ther. 1961; 130, Mar 1; 336-353.
- Kagan Yu.S., Stankevich V.V. Factor accumulation as a quantitative criterion. - In the book: Topical issues of occupational health, industrial toxicology and occupational diseases in the oil and petrochemical industry. Ufa. 1964; 48-49 (in Russian).
- Medved’ L.I., Kagan Yu.S., Spynu E.I. Pesticides and health problems. - J. Proc. chemical. Islands named. Mendeleyev. 1968; Vol. 13, 3: 263-271 (in Russian).
- Golikov, S.N. General mechanisms of toxic action. S.N. Golikov I.V. Sanotsky, L.A Tiunov. L., 1986: 280 (in Russian).
Supplementary files
