Email this article EXPERIMENTAL STUDY OF ALLERGENIC PROPERTIES AND IMMUNOTOXICICITY OF THE DRUG OSCILLOCOCCINUM
- Authors: Kovalenko L.P.1, Tallerova A.V.1, Kuznetsova O.S.1, Lapitskaya A.S.1
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Affiliations:
- Federal State Budgetary Institution «V.V. Zakusov Institute of Pharmacology», Russian Academy of Medical Science
- Issue: No 1 (2015)
- Pages: 37-41
- Section: Articles
- Published: 04.02.2015
- URL: https://rjsocmed.com/0869-7922/article/view/641312
- DOI: https://doi.org/10.15690/vramn436
- ID: 641312
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Abstract
Allergenicity and immunotoxicity of oscillococcinum preparation was experimentally studied. Immunization of guinea pigs with oscillococcinum in doses of 100 mg/kg and 500 mg/kg according to a standard scheme or mixed with complete Freund’s adjuvant ( CFA) did not provoke a systemic anaphylactic reactions or delayed allergenic reactions in animals. A single administration of oscillococcinum per os in doses of 100 mg/kg and 500 mg/kg to CBA strain mice did not cause significant changes in comparison with the control in the inflammation response to concanavalin A (Con.A). To assess oscillococcinum immunotoxic properties, the preparation was perorally administrated to mice in doses of 100 mg/kg and 500 mg/kg for 14 days. Delivery of oscillococcinum in the dose of 500 mg/kg to F1 mice resulted in an authentic increase by 25.1% of thymus mass index. In F1 hybrid mice (CBA x C57BL/6), a course delivery of oscillococcinum induced an expressed increase of peritoneal macrophage phagocytic activity , in C57BL/6 strain mice it significantly stimulated humoral immune response . Thus, oscillococcinum in the dose range investigated does not produce allergenic and immunotoxic action, stimulates macrophage phagocytic activity and humoral response which could be considered one of the most important mechanisms of the preparation action used to cure flu and other acute respiratory viral infections.
About the authors
Larisa Petrovna Kovalenko
Federal State Budgetary Institution «V.V. Zakusov Institute of Pharmacology», Russian Academy of Medical Science
Author for correspondence.
Email: kovalenko.larisa@mail.ru
Доктор биологических наук, ведущий научный сотрудник лаборатории лекарственной токсикологии Федерального государственного бюджетного учреждения «Научно-исследовательского института фармакологии имени В.В. Закусова»
Российской академии медицинских наук
e-mail: kovalenko.larisa@mail.ru
Russian FederationAnna Vadimovna Tallerova
Federal State Budgetary Institution «V.V. Zakusov Institute of Pharmacology», Russian Academy of Medical Science
Email: annatall@rambler.ru
Кандидат биологических наук, старший научный сотрудник лаборатории лекарственной токсикологии Федерального государственного бюджетного учреждения «Научно-исследовательского института фармакологии имени В.В. Закусова»
Российской академии медицинских наук
e-mail: annatall@rambler.ru
Russian FederationOlga Sergeevna Kuznetsova
Federal State Budgetary Institution «V.V. Zakusov Institute of Pharmacology», Russian Academy of Medical Science
Email: olgapharm@inbox.ru
Младший научный сотрудник, сотрудник лаборатории лекарственной токсикологии Федерального государственного бюджетного учреждения «Научно-исследовательского института фармакологии имени В.В. Закусова» Российской
академии медицинских наук
e-mail: olgapharm@inbox.ru
Russian FederationAnastasya Sergeevna Lapitskaya
Federal State Budgetary Institution «V.V. Zakusov Institute of Pharmacology», Russian Academy of Medical Science
Email: lapitskaia.n@mail.ru
Кандидат биологических наук, старший научный сотрудник лаборатории фармакологической генетики Федерального государственного бюджетного учреждения «Научно-исследовательского института фармакологии имени В.В. Закусова» Российской академии медицинских наук
e-mail: lapitskaia.n@mail.ru
Russian FederationReferences
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