Email this article CORRECTION OF THE KIDNEYS STRUCTURE DISTURBANCES IN RATS WITH SUBLIMATE NEPHROPATHY USING A COMBINATION OF TAURIN WITH ZINC DIASPARTATE
- Authors: Basalai O.N.1, Mikhalchuk E.C.1, Bushma M.I.1, Zimatkin S.M.1
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Affiliations:
- УО «Гродненский государственный медицинский университет» МЗ РБ
- Issue: No 2 (2015)
- Pages: 31-34
- Section: Articles
- Published: 06.04.2015
- URL: https://rjsocmed.com/0869-7922/article/view/641310
- DOI: https://doi.org/10.15690/vramn446
- ID: 641310
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Abstract
A combination of taurine (20g/mole, 2.5 g) with zinc diaspartate (1 g/mole, 0.35g) named “taucine”, administrated in the rat stomach at doses of 250 mg/kg and 500 mg/kg over 14 days has a dose-dependent nephro-protective action in rats with sublimate nephropathy ( intraabdominally 0.1 mg/kg over 14 days) . It manifests in an increased volume of the primary urine in cortical nephrons glomerales because of a weakened compression of their capsule by hydropic fluid, in reduction of the inner diameter of cortical nephrons proximal convoluted tubules as consequence of a less pronounced «inner tubular» hydronephrosis and increased height of lining epithelial cells. A detailed analysis of the latter shows that they are less damaged by sublimate: the percentage of undamaged cells increases because of decrease with destruction of apical sections and increase of cells height by ½ as well.
About the authors
Olga Nikolaevna Basalai
УО «Гродненский государственный медицинский университет» МЗ РБ
Author for correspondence.
Email: noemail@neicon.ru
Аспирант, ассистент кафедры фармакологии им. профессора М.В. Кораблева УО ГрГМУ, 230023, г. Гродно, Республика Беларусь
e-mail: Basalai2012@mail.ru
BelarusElena Cheslavovna Mikhalchuk
УО «Гродненский государственный медицинский университет» МЗ РБ
Email: noemail@neicon.ru
К. б. н., доцент кафедры гистологии, цитологии и эмбриологии УО ГрГМУ, 230023, г. Гродно, Республика Беларусь
e-mail: milena6519@mail.ru
BelarusMikhail Ivanovich Bushma
УО «Гродненский государственный медицинский университет» МЗ РБ
Email: noemail@neicon.ru
Д. м. н., профессор, зав. кафедры фармакологии им. профессора М.В. Кораблева УО ГрГМУ, 230023, г. Гродно, Республика Беларусь
e-mail: pharma@grsmu.by
BelarusSergey Mikhaylovich Zimatkin
УО «Гродненский государственный медицинский университет» МЗ РБ
Email: noemail@neicon.ru
Д. б. н., профессор, зав. кафедры гистологии, цитологии и эмбриологии УО ГрГМУ, 230023, г. Гродно, Республика Беларусь
e-mail: zimatkin@grsmu.by
BelarusReferences
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