THE ROLE OF BIO-PREVENTION IN THE FRAMEWORK OF MANAGING OCCUPATIONAL AND ENVIRONMENTAL CHEMICAL RISKS TO POPULATION HEALTH

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Abstract

Environment chemical pollution can be persistent, and even virtually irremovable. For some chemicals in the workplace air, reliably safe low exposure levels are technically unattainable or presumably nonexistent. Further to decreasing harmful exposures to the lowest possible levels, the «biological prophylaxis» aims to enhance host’s protective mechanisms. In over 30 years in animal experiments modeling isolated or combined chronic or sub-chronic exposures to silica, asbestos, monazite, lead, chromium, arsenic, manganese, nickel, vanadium, nano silver, nano copper, formaldehyde, phenol, naphthalene, benzo(a)pyrene, were tested so-called «bio-prophylactic complexes» (BPCs) comprising innocuous substances with theoretically expected beneficial influence on the toxicokinetics and/or toxicodynamics of those toxics. The BPCs tested up to now proved capable of mitigating systemic toxicity, cytotoxicity, fibrogenicity, and mutagenicity of the above-listed chemicals. Most of these BPCs were then subjected to controlled field trials involving restricted groups of volunteers. Once the effectiveness and safety of a BPC was established, it was recommended for practical use, first of all, in the most vulnerable population groups (children, pregnant women) and in the most harmful occupations.

About the authors

Boris Aleksandrovich Katsnelson

Medical Research Center for Prophylaxis and Health Protection in Industrial Workers

Author for correspondence.
Email: bkaznelson@etel.ru

Д.м.н., профессор, заведующий отделом Токсикологии и биопрофилактики ФБУН ЕМНЦПОЗРПП, 620014, г. Екатеринбург

e-mail: bkaznelson@etel.ru

Russian Federation

Larisa Ivanovna Privalova

Medical Research Center for Prophylaxis and Health Protection in Industrial Workers

Email: privalovali@yahoo.com

Д.м.н., профессор, заведующая лабораторией научных основ биопрофилактики ФБУН ЕМНЦПОЗРПП; 620014, г. Екатеринбург

e-mail: privalovali@yahoo.com

Russian Federation

Vladimir Borisovich Gurvich

Medical Research Center for Prophylaxis and Health Protection in Industrial Workers

Email: gurvich@ymrc.ru

Д.м.н., директор ФБУН ЕМНЦПОЗРПП; 620014, г. Екатеринбург

e-mail: gurvich@ymrc.ru

Russian Federation

Sergey Vladimirovich Kuzmin

Medical Research Center for Prophylaxis and Health Protection in Industrial Workers; Sverdlovsk Regional Office of the Federal Service for Surveillance on Consumer Rights Protection and Human Well-being (Rospotrebnadzor)

Email: kuzmin_sv@66.rospotrebnadzor.ru

Д.м.н., профессор, руководитель управления Роспотребнадзора по Свердловской области; 620078, г. Екатеринбург

e-mail: kuzmin_sv@66.rospotrebnadzor.ru

Russian Federation

Ekaterina Petrovna Kireyeva

Medical Research Center for Prophylaxis and Health Protection in Industrial Workers

Email: katerinakir@yandex.ru

К.м.н., ст. научный сотрудник лаборатории научных основ биопрофилактики ФБУН ЕМНЦПОЗРПП, 620014, г. Екатеринбург

e-mail: katerinakir@yandex.ru

Russian Federation

Ilzira Amirovna Minigalieva

Medical Research Center for Prophylaxis and Health Protection in Industrial Workers

Email: noemail@neicon.ru

К.б.н., заведующая лабораторией промышленной токсикологии ФБУН ЕМНЦПОЗРПП, 620014, г. Екатеринбург

e-mail: ilzira-minigalieva@yandex.ru

Russian Federation

Marina Petrovna Sutunkova

Medical Research Center for Prophylaxis and Health Protection in Industrial Workers

Email: noemail@neicon.ru

К.м.н., заведующая лабораторией токсикологии окружающей среды ФБУН ЕМНЦПОЗРПП, 620014, г. Екатеринбург

e-mail: marinasutunkova@yandex.ru

Russian Federation

Nadezhda Vladimirovna Loginova

Medical Research Center for Prophylaxis and Health Protection in Industrial Workers

Email: tushkann@yandex.ru

Научный сотрудник лаборатории научных основ биопрофилактики ФБУН ЕМНЦПОЗРПП, 620014, г. Екатеринбург

e-mail: tushkann@yandex.ru

Russian Federation

Olga Leonidovna Malykh

Sverdlovsk Regional Office of the Federal Service for Surveillance on Consumer Rights Protection and Human Well-being (Rospotrebnadzor)

Email: noemail@neicon.ru

К.м.н., начальник отдела соцгигмониторинга управления Роспотребнадзора по Свердловской области; 620078, г. Екатеринбург

Russian Federation

Sergey Vladimirovich Yarushin

Medical Research Center for Prophylaxis and Health Protection in Industrial Workers

Email: sergeyy@ymrc.ru

Заведующий лабораторией соцгигмониторинга и управления рисками ФБУН ЕМНЦПОЗРПП, 620014, г. Екатеринбург

e-mail: sergeyy@ymrc.ru 

Russian Federation

Julia Ivanovna Soloboyeva

Medical Research Center for Prophylaxis and Health Protection in Industrial Workers

Email: noemail@neicon.ru

К.м.н., ведущий научный сотрудник лаборатории соцгигмониторинга и управления рисками ФБУН ЕМНЦПОЗРПП, 620014, г. Екатеринбург

e-mail: soloboyeva@ymrc.ru

Russian Federation

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Copyright (c) 2015 Katsnelson B.A., Privalova L.I., Gurvich V.B., Kuzmin S.V., Kireyeva E.P., Minigalieva I.A., Sutunkova M.P., Loginova N.V., Malykh O.L., Yarushin S.V., Soloboyeva J.I.


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