Email this article NEUROTOXICOLOGICAL PROPERTIES OF THE COMPOUND AV-19 FOR PROPHYLAXIS AND TREATMENT OF COMPLICATIONS OF DIABETES MELLITUS
- Authors: Maltsev D.V.1,2, Spasov A.A.1,2, Kosolapov V.A.1, Sultanova K.T.1,2, Miroshnikov M.V.1, Kotovskaya S.K.3, Sapozhnikova I.M.3, Rusinov V.L.3
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Affiliations:
- Volgograd State Medical University, Ministry of Health of the Russian Federation
- Volgograd Medical Scientific Center
- Ural Federal University named after the fi rst President of Russia B.N. Yeltsin
- Issue: No 4 (2020)
- Pages: 39-43
- Section: Articles
- Published: 31.07.2020
- URL: https://rjsocmed.com/0869-7922/article/view/641258
- DOI: https://doi.org/10.36946/0869-7922-2020-4-39-43
- ID: 641258
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Abstract
The article presents the results of a study of the neurotoxicological profile of the new compound AB-19, acting on collagen glycation end products (AGE) and their receptors (RAGE), for the prevention and treatment of diabetes complications. The multi-test method «S. Irwin» was used. The test results were evaluated in parallel groups receiving the substance in doses starting with the average effective dose (ED50) and with a multiple increase by 5, 10, 20 and 50 times. It was found that the compound AB-19 in doses of 20, 100 and 200 mg / kg does not affect the functional and behavioral status of animals. However, with an increase to 400 mg / kg, typical manifestations of intoxication were observed: a decrease in muscle tone, hypothermia, sedation, tachypnea. As a result of the study, it was revealed that the neurotoxicological properties of the compound AB-19 are characterized by dose-dependent activity. A minimum toxic dose of 400 mg / kg ≤ Tdmin ≤ 1000 mg / kg was also indicated.
About the authors
D. V. Maltsev
Volgograd State Medical University, Ministry of Health of the Russian Federation; Volgograd Medical Scientific Center
Author for correspondence.
Email: maltsevdmitriy@rambler.ru
Maltsev Dmitriy Vasil’evich
400131, Volgograd
400131, Volgograd
Russian FederationA. A. Spasov
Volgograd State Medical University, Ministry of Health of the Russian Federation; Volgograd Medical Scientific Center
Email: aspasov@mail.ru
Spasov Aleksandr Alekseevich
400131, Volgograd
400131, Volgograd
Russian FederationV. A. Kosolapov
Volgograd State Medical University, Ministry of Health of the Russian Federation
Email: vad-ak@mail.ru
Kosolapov Vadim Anatol’evich
400131, Volgograd
Russian FederationK. T. Sultanova
Volgograd State Medical University, Ministry of Health of the Russian Federation; Volgograd Medical Scientific Center
Email: sultanova.pharma@gmail.com
Sultanova Kira Timurovna
400131, Volgograd
400131, Volgograd
Russian FederationM. V. Miroshnikov
Volgograd State Medical University, Ministry of Health of the Russian Federation
Email: mihailmiroshnikov@mail.ru
Miroshnikov Mikhail Vladimirovich
400131, Volgograd
Russian FederationS. K. Kotovskaya
Ural Federal University named after the fi rst President of Russia B.N. Yeltsin
Email: s.k.kotovskaya@urfu.ru
Kotovskaya Svetlana Konstantinovna
620002, Yekaterinburg
Russian FederationI. M. Sapozhnikova
Ural Federal University named after the fi rst President of Russia B.N. Yeltsin
Email: i.m.sapozhnikova@urfu.ru
Sapozhnikova Irina Mikhailovna
620002, Yekaterinburg
Russian FederationV. L. Rusinov
Ural Federal University named after the fi rst President of Russia B.N. Yeltsin
Email: v.l.rusinov@urfu.ru
Rusinov Vladimir Leonidovich
620002, Yekaterinburg
Russian FederationReferences
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