LEAD AND CADMIUM SUBCHRONIC INTOXICATION IN RATS AS A FACTOR OF DAMAGE TO THE CARDIOVASCULAR SYSTEM

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Abstract

Lead-cadmium intoxication is an occupational risk factor for copper-smelting industry workers. People inhabiting the areas near the copper plants are also at risk. Subchronic intoxication was modeled by repeated intraperitoneal injections of lead acetate and cadmium chloride both in isolation and in combination, 3 times a week for 6 weeks. A heart rate decrease in animals with Cd intoxication and a blood flow velocity decrease in those with Pb intoxication have been found. The impact of Pb and Cd on blood pressure proved to be contra-directional. ECG analysis revealed a prolonged duration of QRS in Cd intoxication, a prolonged QT interval and a baseline lowering in Pb+Cd intoxication. A variety of changes has been found with respect to the diameter of cardiomyocytes and the thickness of aortic wall layers in Pb and/or Cd intoxication. Any toxic exposure resulted in the decrease in number of nuclei per unit area of myocardium histological preparation.

About the authors

S. V. Klinova

Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers of Rospotrebnadzor

Author for correspondence.
Email: klinova.svetlana@gmail.com

Klinova Svetlana Vladislavovna

620014, Yekaterinburg

Russian Federation

I. A. Minigalieva

Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers of Rospotrebnadzor

Email: ilzira-minigalieva@yandex.ru

Minigalieva Ilzira Amirovna

620014, Yekaterinburg

Russian Federation

L. I. Privalova

Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers of Rospotrebnadzor

Email: privalovali@yahoo.com

Privalova Larisa Ivanovna

620014, Yekaterinburg

Russian Federation

M. P. Sutunkova

Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers of Rospotrebnadzor

Email: marinasutunkova@yandex.ru

Sutunkova Marina Petrovna

620014, Yekaterinburg

Russian Federation

V. B. Gurvich

Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers of Rospotrebnadzor

Email: gurvich@ymrc.ru

Gurvich Vladimir Borisovich

620014, Yekaterinburg

Russian Federation

Ju. V. Ryabova

Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers of Rospotrebnadzor

Email: ryabova@ymrc.ru

Ryabova Juliya Vladimirovna

620014, Yekaterinburg

Russian Federation

S. N. Solovjeva

Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers of Rospotrebnadzor

Email: solovyevasn@ymrc.ru

Solovjeva Svetlana Nikolaevna

620014, Yekaterinburg

Russian Federation

V. G. Panov

Institute of Industrial Ecology, Urals Branch of the Russian Academy of Sciences

Email: vpanov@ecko.uran.ru

Panov Vladimir Grigorievich

620990, Yekaterinburg

Russian Federation

I. E. Valamina

Central Research Laboratory, Ural State Medical University

Email: ivalamina@mail.ru

Valamina Irina vgenievna

620109, Yekaterinburg

Russian Federation

I. N. Chernishov

Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers of Rospotrebnadzor

Email: chernishov@ymrc.ru

Chernishov Ivan Nikolaevich

620014, Yekaterinburg

Russian Federation

B. A. Katsnelson

Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers of Rospotrebnadzor

Email: bkaznelson@etel.ru

Katsnelson Boris Aleksandrovich

620014, Yekaterinburg

Russian Federation

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Copyright (c) 2020 Klinova S.V., Minigalieva I.A., Privalova L.I., Sutunkova M.P., Gurvich V.B., Ryabova J.V., Solovjeva S.N., Panov V.G., Valamina I.E., Chernishov I.N., Katsnelson B.A.


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