GENOTOXIC ACTIVITY OF THE PESTICIDE MIXTURES

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Abstract

In order to overcome resistance to individual pesticides and improve their effectiveness, formulations containing two or more active substances are constantly being developed and put on the market over recent years. Mixtures of residual amounts of pesticides can be present in water and food and enter the human and animal bodies. However, the combined effect of pesticides on living organisms, including genetic structures in cells, has not been studied enough and it is not yet possible to predict the genotoxic effects of their mixtures based on available data.
The purpose of this review was to collect and summarize literature information on the genotoxicity of pesticide combinations obtained at different objects. The results of studies conducted in different countries of the world are discussed, examples of detected synergistic, additive and antagonistic effects are given, indicating the need for testing the genotoxicity of preparative forms of pesticides containing several active substances, as well as mixtures of jointly used pesticides in order to ensure the safe use of pesticides for public health.

About the authors

N. A. Ilyushina

F.F. Erisman Federal Research Center of Hygiene of Rospotrebnadzor

Author for correspondence.
Email: Ilyushina-na@mail.ru
ORCID iD: 0000-0001-9122-9465

Ilyushina Nataliya Alexeevna

141014, Mytishchi, Moscow Region

Russian Federation

Yu. A. Revazova

F.F. Erisman Federal Research Center of Hygiene of Rospotrebnadzor

Email: revazova013@gmail.com
ORCID iD: 0000-0001-5067-5469

Revazova Yulia Anatolievna

141014, Mytishchi, Moscow Region

Russian Federation

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