THYROID STATUS IN MOUSE-LIKE RODENTS UNDER THE INFLUENCE OF SYNTHETIC PYRETHROID CYPERMETHRIN

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Abstract

The aim of this work was to evaluate the thyroid status in mouse-like rodents under the influence of synthetic pyrethroid cypermethrin.

The studies were performed on 168 male rats (Rattus norvegicus) and 112 male red voles (Myodes rutilus). When simulating acute intoxication, cypermethrin was injected once into the stomach at a dose of lA LD50 followed by observation of rats for 30 days and voles for 7 days. When studying chronic intoxication, cypermethrin was administered to rats at a dose of 1/100 LD50, the duration of the experiment was 120 days. Acaricidal treatment of the forest was carried out on a one-hectare site, and the results of the capture of voles and their thyroid status were compared with voles caught on the background site.

Synthetic pyrethroid cypermethrin in acute and chronic experiments causes a change in thyroid status in laboratory rats, which is reflected in a decrease in the level of thyroid hormones in the blood serum. Moreover, there is an increase in the level of thyroid-stimulating hormone in rats. The introduction of a high dose of cypermethrin (A LD50) into male voles under field vivarium conditions also revealed the sensitivity of representatives of this species to the action of synthetic pyrethroids, which was manifested in a decrease in the synthesis of T4 and T3 in their thyroid glands. Acaricidal forest treatment contributes to a temporary change in thyroid status in male red field vole (Myodes rutilus) caught in the treated area, which, apparently, is a consequence of adaptive changes and migration processes in the population of this species.

About the authors

E. A. Chigrinski

Omsk State Medical University, Ministry of Healthcare of the Russian Federation

Author for correspondence.
Email: chigrinski@list.ru

Chigrinski Eugene Alexandrovich

644099, Omsk

Russian Federation

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