Indicators of the antioxidant system in the long-term period after acute mercury nitrate poisoning in the experiment

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Abstract

The article presents experimental data on the state of the antioxidant system in red blood cells of white outbred rats 1 and 3 months after acute mercury nitrate poisoning with a semilethal dose. It has been established that this form of intoxication is accompanied by pronounced changes in the state of the antioxidant defense system in erythrocytes of poisoned animals (a decrease in the concentration of reduced glutathione, a decrease in the activity of superoxide dismutase and glutathione peroxidase, and an increase in the concentration of lipid peroxidation products).

It has been shown that the mercury content in the blood of experimental animals remains elevated during the entire study period.

The results obtained indicate the importance of impaired functioning of the antioxidant system in the implementation of long-term consequences of acute mercury poisoning. The reasons for the occurrence of these biochemical shifts and their role in the development of the long-term cytotoxic effects of mercury nitrate are discussed.

About the authors

E. G. Batotsyrenova

Institute of Toxicology of the Federal Medical Biological Agency;
Saint Petersburg State Pediatric Medical University

Author for correspondence.
Email: bkaterina2009@yandex.ru

Batotsyrenova Ekaterina Gennad’evna

192019, Saint Petersburg; 194100, Saint Petersburg

Russian Federation

O. A. Vakunenkova

Institute of Toxicology of the Federal Medical Biological Agency

Email: volga-2303@yandex.ru

Vakunenkova Olga Alexandrovna

192019, Saint Petersburg

Russian Federation

E. A. Zolotoverkhaya

Institute of Toxicology of the Federal Medical Biological Agency

Email: orzheskovskaya@mail.ru

Zolotoverkhaya Ekaterina Andreevna

192019, Saint Petersburg

Russian Federation

V. A. Kashuro

Institute of Toxicology of the Federal Medical Biological Agency

Email: kashuro@yandex.ru

Kashuro Vadim Anatolyevich

192019, Saint Petersburg

Russian Federation

T. A. Kostrova

Institute of Toxicology of the Federal Medical Biological Agency

Email: tasia.pcma.le4@mail.ru

Kostrova Taisia Alexandrovna

192019, Saint Petersburg

Russian Federation

L. G. Kubarskaya

Institute of Toxicology of the Federal Medical Biological Agency

Email: larkub@yandex.ru

Kubarskaya Larisa Georgyevna

192019, Saint Petersburg

Russian Federation

N. V. Lapina

Institute of Toxicology of the Federal Medical Biological Agency

Email: lapina2005@inbox.ru

Lapina Natalia Vadimovna

192019, Saint Petersburg

Russian Federation

K. M. Shchepetkova

Institute of Toxicology of the Federal Medical Biological Agency

Email: tesh_07@inbox.ru

Shchepetkova Kristina Mihailovna

192019, Saint Petersburg

Russian Federation

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