Email this article FEATURES OF LEAD ELIMINATION IN RATS FOR ITS PARENTERAL ADMINISTRATION
- Authors: Shemaev M.E.1, Malov A.M.1, Sibiryakov V.K.1, Glushkov R.K.1
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Affiliations:
- Institute of Toxicology, Federal Medical-Biological Agency
- Issue: No 5 (2019)
- Pages: 45-48
- Section: Articles
- Published: 28.10.2019
- URL: https://rjsocmed.com/0869-7922/article/view/641205
- DOI: https://doi.org/10.36946/0869-7922-2019-5-45-48
- ID: 641205
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Abstract
The data on lead elimination from the body of rats with urine and feces for parenteral administration of the toxicant are presented. Three times introduction of lead acetate in daily doses (lead) of 15 mg/kg, 45 mg/kg, and 60 mg/kg was used. The lead content was determined by inversion voltammetry and atomic emission spectroscopy. It has been shown that lead elimination is dose-dependent and can be described by a 2nd order polynomial.
On the 20th day of the experiment, 6% to 10% of the lead introduced into the body of rats has been eliminated depending on the lead dose. The relationship between the renal and intestinal routes of toxicant excretion depends on the dose of lead seed. The half-lives of lead turned out to be 61,9 days for a dose of 15 mg/kg, 69,5 days for a dose of 45 mg/kg, and 70,8 days for a dose of 60 mg/kg. The presented model can be used to assess the effect of therapeutic agents used in lead poisoning.
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About the authors
M. E. Shemaev
Institute of Toxicology, Federal Medical-Biological Agency
Author for correspondence.
Email: shemaevm@mail.ru
Shemaev Mikhail Evgen’evich
192019, Saint Petersburg Russian FederationA. M. Malov
Institute of Toxicology, Federal Medical-Biological Agency
Email: malexmish@rambler.ru
Malov Aleksandr Mihajlovich
192019, Saint Petersburg
Russian FederationV. K. Sibiryakov
Institute of Toxicology, Federal Medical-Biological Agency
Email: fake@neicon.ru
Sibirjakov Viktor Konstantinovich
192019, Saint Petersburg
Russian FederationR. K. Glushkov
Institute of Toxicology, Federal Medical-Biological Agency
Email: fake@neicon.ru
Glushkov Rudolf Konstantinovich
192019, Saint Petersburg
Russian FederationReferences
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