Email this article TOXICITY AND HAZARD OF NEUROPARALYTIC ACTION OF FIRE-RESISTANT TURBINE OILS BASED ON TRIARYL PHOSPHATES
- Authors: Sidorin G.I.1, Lukovnikova L.V.1, Dyakova L.I.1, Shestova G.V.1
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Affiliations:
- Institute of Toxicology of the Federal Medical Biological Agency
- Issue: No 1 (2020)
- Pages: 27-33
- Section: Articles
- Published: 24.02.2020
- URL: https://rjsocmed.com/0869-7922/article/view/641198
- DOI: https://doi.org/10.36946/0869-7922-2020-1-27-33
- ID: 641198
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Abstract
The paper presents the results of assessing the toxicity and danger of the development of neuroparalytic effect of fire-resistant turbine oils «Turbomas», «T-94» and «T-95» based on triaryl phosphates. According to the toxicity parameters, the studied oils are low-toxic substances, exhibit weakly expressed cumulative properties, do not irritate the skin and mucous membranes, penetrate through intact skin, and increase the activity of microsomal enzymes, when injected into the stomach and abdominal cavity. The study of the neuroparalytic action of oils «Turbomas», «T-94» and «T-95» did not reveal the presence of clinical and morphological signs of disorders of the neuromuscular apparatus in animals, which makes it possible to exclude the possibility of neuroparalytic action in persons in contact with the studied oils.
About the authors
G. I. Sidorin
Institute of Toxicology of the Federal Medical Biological Agency
Author for correspondence.
Email: sidorin.g@mail.ru
192019, Saint Petersburg Russian Federation
L. V. Lukovnikova
Institute of Toxicology of the Federal Medical Biological Agency
Email: lukovnikova.l.v@toxicology.ru
192019, Saint Petersburg Russian Federation
L. I. Dyakova
Institute of Toxicology of the Federal Medical Biological Agency
Email: lukovnikova.l.v@toxicology.ru
192019, Saint Petersburg Russian Federation
G. V. Shestova
Institute of Toxicology of the Federal Medical Biological Agency
Email: gvshestova@mail.ru
192019, Saint Petersburg Russian Federation
References
- Zil’ber Yu.D. Neuroparalytic action of poisons. In: Topical issues of industrial toxicology. Leningrad; 1970: 129-144..; (in Russian).
- Zil’ber Yu.D. Peculiarities of toxic properties of triaryl phosphates and some mechanisms of their demyelinating action. In: Questions of general and private industrial toxicology. Leningrad; 1965: 135-152. (in Russian).
- Drogichina E.A. Toxic polyneuritis and encephalomyeline neuritis. Moscow: Meditsina; 1959. (in Russian).
- Drogichina E.A., Tolgskaya M.S. To the histology of the nervous system during experimental intoxication with triortoresylphosphate. Trudy AMN SSSR. 1954; 31: 189-202. (in Russian).
- Kagan Yu.S. Biomedical aspects of the problem of preventing exposure to pesticides. Vestnik Akademii meditsinskikh nauk SSSR. 1991;1: 48-52. (in Russian).
- Zil’ber YU.D., Gadaskina I.D. The toxicity of triaryl phosphates and the development of measures for their safe use as fire-resistant turbine oils. In: Fire-resistant turbine oils. Moscow; 1974: 89-99. (in Russian).
- Chepur S.V. Distant organophosphate neuropathies: pathogenesis, prevention and treatment. Toksikologicheskiy vestnik. 2010; 3: 42-43. (in Russian).
- Dvorkin E.A. Chemical structure and biological action of orthophosphoric acid esters. In: Some issues of experimental industrial toxicology. Leningrad; 1977: 18-23. (in Russian).
- Неnschler D., Die Trikresylphosphat Vergiftung. Klinische Wochen-schrift. 1958; 36 (14): 663-674.
- Trofimov V.A., Dvorkin E.A. Toxicological and hygienic assessment of fire-resistant oil OMTI. Gigiena truda. 1974; 10: 25-28. (in Russian).
- Lim R. K., Rink K.G., Glass H.G. [at al.] A metod for the evaluation of cumulation and tolerance by the determination of acute and subchronic median effective doses. Archives Internationales De Pharmacodynamie Et De Therapie. 1961; 30: 336-353.
- Zakusov V.V. Farmakologiya central’nyh sinapsov. Moscow: Medicina; 1973. (in Russian).
- Frolova A.D., Dvorkin E.A., Lisman M.B., Lukovnikova L.V., Nechaeva E.N., Sidorin G.I. K ispol’zovaniyu pokazatelej povedencheskih reakcij v toksikologicheskom eksperimente. Gigiena i sanitariya. 1980; 8:53-57. (in Russian).
- Tiunov L.A. The main mechanisms of xenobiotic metabolism in humans and animals. In: Results of science and technology. Toxicology. Moscow; 1981: 12: 5-64. (in Russian).
- Laboratory research, methods in clinic V.V. Men’shikova. Moscow: Medicina, 1987 (in Russian).
- Alekseyeva O.G., Duyeva L.A. Allergy to industrial chemicals. Moscow: Medicina; 1978. (in Russian).
- Lukovnikova L.V., Sidorin G.I., D’yakova L.I. About toxicity and danger of fire-resistant turbine oil «Turbomas». In: Materials of the International Forum of the Scientific Council of the Russian Federation on Human Ecology and Environmental Hygiene: «Current problems of assessing, forecasting and managing environmental risks to public health and the environment, ways to solve them rationally Moscow»; 2018: 213-215. (in Russian).
- Song M. I. Involvement of autophagy in tri-orto-cresyl phosphate-indused delayed neuropathy in hens. Neurochemistry International. 2014; 64: 1-8.
- Reji K. K., Mathew V., Zachariah A. [et al.] Extrapyramidal effects of acute organophosphate poisoning. Clinical toxicology. 2016; 54 (3): 259-265.
- Abuser Coskun, Afsin Emre Kayipmaz, Sedat Ozbay1, Osman Mahir Okur Delayed organophosphate induced polyneuropathy. Medical Science and Discovery. 2015; 4 (2): 271-274.
- Indu T.H., Raja D., Ponnusankar S. Toxicoepidemiology of acute poisoning cases in secondary care hospital in rural South India: A fife-year analysis. Postgraduate Medical Journal. 2015; 61 (3): 159-162.
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