Effect of reconstituted glutathione preparations on bioelectric brain activity in severe ethanol poisoning

Fifty patients with acute severe ethanol poisoning (depression of consciousness at the time of admission was up to the level of coma) were examined. Based on the purpose of the study, patients were divided into two groups. In the first group, basic etiopathogenetic therapy was supplemented by the intravenous administration of a drug based on reduced glutathione: inosine glycyl-cysteinyl-glutamate disodium (IGCGD). In the second group, only basic therapy was performed. All patients underwent in the intensive care long-term continuous EEG monitoring, which was started at the end of basic resuscitation and stopped when the patient was clearly awake. Based on the nature of spontaneous EEG and reactivity, patients were divided into subgroups: patients with theta coma pattern and patients with delta coma pattern.

It was found that the introduction of IGCGD in the treatment of severe ethanol poisoning in the group of patients with a reactive delta pattern significantly increased the rate of formation of awakening in the EEG: in the subgroup with basic therapy, the formation time of the awakening pattern was about 3 hours, and in the subgroup of patients to whom the drug was administered 1,5 hours. In the group of patients with depression of EEG to the level of theta coma, IGCGD had no effect on the time of formation of the EEG pattern of awakening. The inclusion of inosine IGCGD in the treatment of severe alcohol intoxication was not accompanied by more frequent formation of epileptiform activity in the EEG.