EFFECTS OF FATTY ACIDS ON BINDING AND ESTERASE ACTIVITY OF ALBUMIN TOWARDS ORGANOPHOSPHORUS COMPOUNDS ACCORDING TO MOLECULAR MODELING APPROACH

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Abstract

One of the urgent tasks of clinical toxicology is the development of therapy aimed at stoichiometric and/or catalytic detoxification of organophosphorus compounds in the bloodstream, which will prevent the poison’s entering the neuromuscular and neuronal synapses and help to avoid irreversible consequences of poisoning. An auxiliary option for the detoxification of organophosphorus compounds in the bloodstream may be a directed effect on albumin, the main transport protein of the blood, by means of molecules modulating its binding and/or esterase properties. The aim of the present study is to evaluate the effect of fatty acids on the binding and esterase activity of human albumin to organophosphorus compounds by molecular modeling methods on the example of paroxone and oleic acid. According to the data obtained, an increased concentration of fatty acids in the blood reduces the likelihood of paraoxon binding to albumin and pseudo-esterase reaction.

About the authors

D. A. Belinskaya

I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Science

Author for correspondence.
Email: d_belinskaya@mail.ru

Belinskaia Daria Alexandrovna

194223, Saint Petersburg

Russian Federation

A. A. Batalova

I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Science

Email: batalova.phys@gmail.com

Batalova Anastasia Alexandrovna

194223, Saint Petersburg

Russian Federation

N. V. Goncharov

I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Science;
Research Institute of Hygiene, Occupational Pathology and Human Ecology

Email: ngoncharov@gmail.com

Goncharov Nikolay Vasil’evich

194223, Saint Petersburg, 188663, p.o. Kuz’molovsky, Leningrad Region

Russian Federation

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