Email this article NEUROTOXICOLOGICAL PROFILE OF 5-НТ2А-ANTAGONIST OF IMIDAZOBENZIMIDAZOLE DERIVATIVE
- Authors: Spasov A.A.1,2, Yakovlev D.S.1,2, Maltsev D.V.1,2, Miroshnikov M.V.1, Sultanova K.T.1, Zhukovskaya O.N.3, Anisimova V.A.3, Nechaevа K.A.1
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Affiliations:
- Volgograd State Medical University
- Volgograd Medical Research Center
- Research Institute of Physical and Organic Chemistry, Southern Federal University
- Issue: No 1 (2019)
- Pages: 23-28
- Section: Articles
- Published: 28.02.2019
- URL: https://rjsocmed.com/0869-7922/article/view/641136
- DOI: https://doi.org/10.36946/0869-7922-2019-1-23-28
- ID: 641136
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Abstract
Thearticlepresentstheresultsofastudyoftheneurotoxicologicalprofileofanew5-HT2A-antagonist(compoundI) using the method of multi-test observation by «S. Irwin». The test parameters were evaluated in parallel groups, receiving the compound in doses beginning with the average effective dose (ED50) and with a multiple increase of 2, 5, 7.5 and 10 times.
The study revealed that the neurotoxicological properties of compound I are characterized by dose-dependent activity. It has been shown that neurotoxicological changes in the behavior of the animals did not occur with the administration of compound I at average effective dose of 10 mg / kg and doses, exceeding the effective by 2 and 5 times; the animals welfare corresponds to that of the control group. The most significant effects by the administration of the studied compound developed in high doses, exceeding the effective by 7.5 and 10 times. The limits of the minimum toxic dose (TDmin) for compound I by oral administration has been found to be 50 mg / kg
About the authors
A. A. Spasov
Volgograd State Medical University;Volgograd Medical Research Center
Author for correspondence.
Email: aspasov@mail.ru
Spasov Aleksandr Alekseyevich
400131, Volgograd
Russian FederationD. S. Yakovlev
Volgograd State Medical University;Volgograd Medical Research Center
Email: dypharm@list.ru
Yakovlev Dmitriy Sergeyevich
400131, Volgograd
Russian FederationD. V. Maltsev
Volgograd State Medical University;Volgograd Medical Research Center
Email: maltsevdmitriy@rambler.ru
Maltsev Dmitriy Vasil’yevich
400131, Volgograd
Russian FederationM. V. Miroshnikov
Volgograd State Medical University
Email: mihailmiroshnikov@mail.ru
Anisimova Vera Alekseyevna
400131, Volgograd
Russian FederationK. T. Sultanova
Volgograd State Medical University
Email: sultanova.pharma@gmail.com
Sultanova Kira Timurovna
400131, Volgograd
Russian FederationO. N. Zhukovskaya
Research Institute of Physical and Organic Chemistry, Southern Federal University
Email: onzhukovskaya@sfedu.ru
Zhukovskaya Ol’ga Nikolayevna
344006, Rostov-on-Don
Russian FederationV. A. Anisimova
Research Institute of Physical and Organic Chemistry, Southern Federal University
Email: vaanisimova@sfedu.ru
Anisimova Vera Alekseyevna
344006, Rostov-on-Don
Russian FederationK. A. Nechaevа
Volgograd State Medical University
Email: owlscheeks@gmail.com
Nechayeva Kseniya Andreyevna
400131, Volgograd
Russian FederationReferences
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