ROLE OF THE STROMAL CELLULAR COMPONENT IN COMPENSATORY PROCESSES IN DIFFUSE LIVER DAMAGE

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Abstract

The aim of the study was to assess the role of the cellular component of the stroma in liver regeneration after its toxic damage. The experimental model of toxic hepatitis caused by intraperitoneal administration of tetrachloromethane (CCl4) showed that regeneration processes in the liver on the 3rd day are manifested in an increase in binuclear hepatocytes, Ki-67 + cells and hepatocytes dividing by mitosis. The reaction of the stromal component is expressed in an increase in the number of CD45 +, mast and sinusoidal cells (SC). On the 7th day of the development of toxic hepatitis the hepatocyte alteration increases, that is accompanied by a sharp decrease in the mitotic index and the number of Ki-67 + cells. In the stromal component there is a decrease in the number of sinusoidal cells, CD45 + and a significant increase in mast cells with a high secretion granule content.

About the authors

Z. A. Shafigullina

Ural Federal University named after the first President of Russia B. N. Yeltsin, Institute of Natural Sciences and Mathematics; Institute of Immunology and Physiology, Ural Branch of RAS

Author for correspondence.
Email: noemail@neicon.ru
Russian Federation

S. Yu. Medvedeva

Ural Federal University named after the first President of Russia B. N. Yeltsin, Institute of Natural Sciences and Mathematics; Institute of Immunology and Physiology, Ural Branch of RAS

Email: noemail@neicon.ru
Russian Federation

I. G. Danilova

Ural Federal University named after the first President of Russia B. N. Yeltsin, Institute of Natural Sciences and Mathematics; Institute of Immunology and Physiology, Ural Branch of RAS

Email: noemail@neicon.ru
Russian Federation

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Copyright (c) 2018 Shafigullina Z.A., Medvedeva S.Y., Danilova I.G.


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