SOME PECULIARITIES OF THE ORGANISM’S RESPONSES TO A LONG-TERM INHALATION OF SILICA-CONTAINING SUBMICRON (PREDOMINANTLY, NANOSCALE) PARTICLES IN A REAL INDUSTRIAL AEROSOL

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Abstract

Female white rats were exposed in a «nose only» inhalation device to an aerosol containing predominantly submicron (nanoscale included) particles of amorphous silica in a total concentration of 2.6±0.6 or 10.6±2.1 mg/m3, 4 h/day, 5 times a week, during up to 6 months. In an auxiliary experiment with a single-shot intratracheal instillation of these particles, it was shown that they induced a pulmonary cell response comparable with that when administrated a highly cytotoxic and fibrogenic standard quartz dust DQ12. However in a long-term inhalation test, the aerosol investigated proved to be of a very low systemic toxicity and fibrogenicity. This paradox may be explained by a low retention of SiO2 in lungs and other organs due to a relatively high in vivo solubility of those nanoparticles. Nevertheless their genotoxic action and transnasal penetration into the brain urge caution when assessing occupational or environmental hazard of that aerosol.

About the authors

M. P. Sutunkova

Medical Research Center for Prophylaxis and Health Protection in Industrial Workers of Rospotrebnadzor

Author for correspondence.
Email: noemail@neicon.ru
Russian Federation

S. N. Solovyeva

Medical Research Center for Prophylaxis and Health Protection in Industrial Workers of Rospotrebnadzor

Email: noemail@neicon.ru
Russian Federation

B. A. Katsnelson

Medical Research Center for Prophylaxis and Health Protection in Industrial Workers of Rospotrebnadzor

Email: noemail@neicon.ru
Russian Federation

V. B. Gurvich

Medical Research Center for Prophylaxis and Health Protection in Industrial Workers of Rospotrebnadzor

Email: noemail@neicon.ru
Russian Federation

L. I. Privalova

Medical Research Center for Prophylaxis and Health Protection in Industrial Workers of Rospotrebnadzor

Email: noemail@neicon.ru
Russian Federation

I. A. Minigalieva

Medical Research Center for Prophylaxis and Health Protection in Industrial Workers of Rospotrebnadzor

Email: noemail@neicon.ru
Russian Federation

T. V. Slyshkina

Medical Research Center for Prophylaxis and Health Protection in Industrial Workers of Rospotrebnadzor

Email: noemail@neicon.ru
Russian Federation

I. E. Valamina

Central Research Laboratory, Ural State Medical University

Email: noemail@neicon.ru
Russian Federation

V. Ya. Shur

Ural Center for Shared Use «Modern nanotechnologies», Ural Federal University

Email: noemail@neicon.ru
Russian Federation

I. V. Zubarev

Ural Center for Shared Use «Modern nanotechnologies», Ural Federal University

Email: noemail@neicon.ru
Russian Federation

D. K. Kuznetsov

Ural Center for Shared Use «Modern nanotechnologies», Ural Federal University

Email: noemail@neicon.ru
Russian Federation

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Copyright (c) 2017 Sutunkova M.P., Solovyeva S.N., Katsnelson B.A., Gurvich V.B., Privalova L.I., Minigalieva I.A., Slyshkina T.V., Valamina I.E., Shur V.Y., Zubarev I.V., Kuznetsov D.K.


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