CRITICAL CHARACTERISTICS CALCULATIUONS OF THE DISTRIBUTIONS OF ANTICANCER THERAPY CONVENTIONAL INDICATORS ( MEDIAN SURVIVAL, TUMOR GROWTH INHIBITION) AND EVALUATION OF THEIR SIGNIFICANCE BASED ON THE PROBABILITY DISTRIBUION DENSITY FUNCTIONS MODELING

Critical parameters of the distributions rates of inhibition of tumor growth (ITG) indices and increasing median survival (IMS), which are adopted in pre-clinical practice for evaluation of the anticancer potential of original substances were accurately ascertained in experiments in vivo . Under the package Mathematica 9, software modules were created which allowed to assess the statistical reliability of the ITG indicator at the levels of 70% and 90 %, and the IMS rate at the levels of 50 % and 75 %, to calculate the mathematical expectation and confidence intervals for ITG and IMS indicators at any level of the effect, to compare the effectiveness of several drugs based on mathematical expectations and confidence intervals calculated for their ITG and IMS indicators in case of close location of the corresponding formal values, and carry out priori tests on the significance of ITG and IMS taking into account the main influencing factors: variation of parameters in experimental groups and size of experimental and control groups.

rate of inhibition of tumor growth (ITG), rate of increase in lifespan (median survival), standard deviation (SD), expectation (ME), confidence intervals, t-student distribution, normal distribution, cumulative distribution function, probability density function