Artificial blood vessels based on Russian fluoropolymers: pilot study

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Abstract

Artificial blood vessels made from fluoropolymer using electrospinning have high biocompatibility. They have unique combinations of strength, chemical resistance, and open interconnected porosity. This provides favourable conditions for endothelialization. The aim of this study is to investigate the structures and properties of these artificial vessels, formed from Russian fluoropolymer materials such as poly(tetrafluoroethylene), copolymers of vinidene fluoride and tetraflouroethylene, and polyvinylidenefluoroide. Depending on the fluoropolymer used, structural characteristics of vessel walls, surface free energies, strengths, elongations, and interactions with human mesenchymal stem cells are investigated. It has been demonstrated that a copolymer of vinidenedifluoride with tetraflouroethylene represents the most promising material for vessel manufacturing using electrospinning technology.

About the authors

O. V. Kukartseva

National Research Tomsk Polytechnic University; Zueva Institute of Atmospheric Optics Siberian Branch, Russian Academy of Sciences

Email: Ftoroplast@tpu.ru
Tomsk, Russia; Tomsk, Russia

V. M. Buznik

National Research Tomsk State University

Email: Ftoroplast@tpu.ru
Tomsk, Russia

E. Y. Melnik

National Research Tomsk Polytechnic University; Zueva Institute of Atmospheric Optics Siberian Branch, Russian Academy of Sciences

Email: Ftoroplast@tpu.ru
Tomsk, Russia; Tomsk, Russia

A. I. Mishanin

Almazov National Medical Research Center, Ministry of Health of the Russian Federation

Email: Ftoroplast@tpu.ru
Saint Petersburg, Russia

A. S. Golovkin

Almazov National Medical Research Center, Ministry of Health of the Russian Federation

Email: Ftoroplast@tpu.ru
Saint Petersburg, Russia

E. N. Bolbasov

National Research Tomsk Polytechnic University; Zueva Institute of Atmospheric Optics Siberian Branch, Russian Academy of Sciences

Author for correspondence.
Email: Ftoroplast@tpu.ru
Tomsk, Russia; Tomsk, Russia

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