The contribution of transglutaminase-mediated processes to the maintenance and reconsolidation of the long-term context memory in snails

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Resumo

The effects of the transglutaminase inhibitor monodansylcadaverine on context memory maintenance and reconsolidation practically are not investigated. This work was devoted to the analysis of the role of transglutaminase (TG) in the formation, maintenance, and reconsolidation of long-term context memory in the terrestrial snail Helix lucorum. We used the transglutaminase inhibitor monodansylcadaverine and demonstrated an irreversible loss of memory if the inhibitor was injected 24 hrs after training. In conditions of memory reactivation effects of TG inhibitor were absent or diminished suggesting a role of TG in memory maintenance. Obtained results can be explained by participation of TG in epigenetic regulation. Exact mechanisms should be investigated in future.

Sobre autores

A. Zuzina

Institute of Higher Nervous Activity and Neurophysiology, RAS

Autor responsável pela correspondência
Email: lucky-a89@mail.ru
Moscow, Russia

A. Vinarskaya

Institute of Higher Nervous Activity and Neurophysiology, RAS

Email: lucky-a89@mail.ru
Moscow, Russia

P. Balaban

Institute of Higher Nervous Activity and Neurophysiology, RAS

Email: lucky-a89@mail.ru
Moscow, Russia

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