Immunological indices of the human in conditions of the application of individual means of protection of respiratory organs

The purpose of the work was to study reactions of the immune system with the use of additional respiratory resistance arising from the use of personal respiratory protection. The inspiratory resistance to respiration of 20, 40 and 60% Pm_max was used. The study involved 26 male and female cases at the average age of 21, 22, 23 years. Based on the results of the study the short-term (3 minutes) effect of inspiratory resistive loads was shown to have a pronounced effect on the population and subpopulation composition of blood lymphocytes, practically without changing the level of secreted immunoglobulins. Different values of additional resistance to respiration were noted to statistically significantly change the level of biogenic amines: the concentration of epinephrine and norepinephrine with elevating values of resistive loads progressively increased; the serotonin concentration shows the opposite dynamics. The work demonstrates the additional respiratory resistance of 20% Pm_max fail to change the immunological status of the subjects. The resistive respiratory load of 40% Pm_max caused immunosuppressive changes in the population composition of lymphocytes and indices of nonspecific immunological resistance. An additional respiratory resistance of 60% Pm_max induced an immunostimulatory effect in the change in the population composition of lymphocytes and in indices of nonspecific immunological resistance. Based on the data obtained, a suggestion has been made that in designing individual respiratory protection devices it is advisable to limit the value of additional inspiratory resistance to respiration of 20% Pm_max.