Comparative evaluation of autoantibodies levels, reflecting the condition of the cardiovascular system in patients with vibration disease due to local and combined vibration

Cover Page

Cite item

Full Text

Abstract

Introduction. Vibration disease occupies one of the leading places in the structure of occupational pathology and is caused by exposure to both local and general vibration. Since the mechanism of local and general vibration effects on the body differs, it can be assumed that their effect on the cardiovascular system will have distinctive features.

The aim of the work was to study the content of specific autoantibodies, which characterize the state of the cardiovascular system, in patients with vibration disease caused by exposure to local and combined vibration.

Material and methods. The relative levels of specific autoantibodies to antigens, reflecting the state of the heart and the vascular bed, were determined in the blood of persons with vibration disease caused by exposure to local and combined vibration (29 and 36 cases, respectively).

Results. 18 to 26% of persons with the vibratory disease caused by the effect of combined vibration were found to have elevated levels of autoantibodies to components of the membrane and cytoplasm of myocardial cells, components of the cytoplasm of neutrophils and endothelial cells, β1-adrenoreceptors, PAPP-A, and cardiomyosin protein. In the group of individuals exposed to local vibration, the frequency of occurrence of elevated levels of antibodies by more than 20% was detected only for β1-adrenoreceptors and PAPP-A protein. Elevated levels of other indices were observed in 10-14% of individuals in this group. The levels of antibodies to components of the membrane of myocardial cells and platelets were higher in patients with the vibratory disease caused by exposure to a combined vibration than in individuals with vibratory syndrome caused by the action of local vibration.

Conclusion. Elevated levels of auto-AT to platelet membrane structures may be due to changes in their membranes caused by the accumulation of highly toxic lipid peroxidation metabolites.

About the authors

Liudmila B. Masnavieva

East-Siberian Institute of Medical and Ecological Research

Author for correspondence.
Email: Masnavieva_Luda@mail.ru
ORCID iD: 0000-0002-1400-6345

MD, Ph.D., DSci., senior researcher of immunological, biochemical, molecular and genetic researches in the hygiene of East-Siberian Institute of Medical and Ecological Research, Angarsk, 665827, Russian Federation.

e-mail: Masnavieva_Luda@mail.ru

Russian Federation

I. V. Kudaeva

East-Siberian Institute of Medical and Ecological Research

Email: noemail@neicon.ru
ORCID iD: 0000-0002-5608-0818
Russian Federation

Y. A. Kuznetsova

East-Siberian Institute of Medical and Ecological Research

Email: noemail@neicon.ru
ORCID iD: 0000-0002-7852-9954
Russian Federation

O. V. Naumova

East-Siberian Institute of Medical and Ecological Research

Email: noemail@neicon.ru
ORCID iD: 0000-0002-5353-2268
Russian Federation

References

  1. Babanov S.A., Vakurova N.V., Azovskova T.A. Vibration disease. Optimization of diagnostic and therapeutic measures. [Vibratsionnaya bolezn’. Optimizatsiya diagnosticheskikh i lechebnykh meropriyatij]. Samara: Ofort; 2012. 160 p. (in Russian)
  2. Nikolenko Yu.V., Lastkova N.D. From local vibration to vibration sickness. Mezhdunarodnyy nevrologicheskiy zhurnal. 2011; 1 (39): 131–9. (in Russian)
  3. Poteryaeva E.L. Platelet-vascular homeostasis disorders role in vibrational microangiopathies pathogenesis. Byulleten’ SO RAMN. 2004; 4 (114): 52–3. (in Russian)
  4. Kardash O.F., Rybina T.M., Kurash I.A., Danilova T.K., Yurevich L.P. Vascular system changes under occupational vibration influence. Zdorov’e i okruzhayushchaya sreda. 2013; (23): 33–6. (in Russian)
  5. Poletaev A.B. Molecular clinical examination (new approaches to the early detection of pathological changes in the human body). Introduction to theory and guidelines for doctors. [Molekulyarnaya dispanserizatsiya (novye podkhody k rannemu vyyavleniyu patologicheskikh izmeneniy v organizme cheloveka). Vvedenie v teoriyu i metodicheskie rekomendatsii dlya vrachey]. Mоcоw: Immunkulus; 2014. 84 p. (in Russian)
  6. Babanov S., Tatarovskaya N. Pneumatic hammer disease in the practice of a therapist and a neurologist. Vrach. 2013; 9: 9–15. (in Russian)
  7. Gerasimenko O.N., Shpagina L.A., Chernyshev V.M., Poteryaeva E.L., Vlasenko V.V., Tsyrendorzhiev D.D. Studying leucocyte-endothelial mechanisms for diagnosis of vascular disorders in vibration disease. Meditsina truda i promyshlennaya ekologiya [Occupational health and industrial ecology]. 2005; 10: 21–5. (In Russian)
  8. Kovalevskiy A.M. Vibration influence on humans’ organism and masticatory apparatus tissues (review of literature). Parodontologiya. 2010; 15 (1): 29–38. (in Russian)
  9. Bаbаnov S.А., Tаtаrovskаya N.А. Vibration disease: modern understanding and differential diagnosis. Russkiy meditsinskiy zhurnаl. Meditsinskoe obozrenie. 2013; 21 (35): 1777–84. (in Russian)
  10. Perremans S. Influence of vertical vibration on heart rate of pigs. J Anim Su. 1998; 76 (2): 416–20. https://doi.org/10.2527/1998.762416x
  11. Gemne G. Pathophysiology of white fingers in workers using hand-held vibration tools. Nagoya J Med Sci. 1994; 57 (5): 87–97.
  12. Antoshina L.I., Pavlovskaya N.A., Yatsyna I.V. The informative laboratory biomarkers for detection of negative impact of vibration on organism of workers. Klinicheskaya laboratornaya diagnostika. 2015; 60 (1): 19–23. (in Russian)
  13. Shpagina L.A., Gerasimenko O.N., Drobyshev V.A., Chachibaya Z.K. Cellular and molecular markers of endothelial dysfunction and systemic hemostasis at pneumatic hammer disease combined with arterial hypertension. Meditsina i obrazovanie v Sibiri. 2014; (6): 42. (in Russian)
  14. Poletaev A.B., Churilov L.P., Stroev Y.I., Agapov M.M. Immunophysiology versus immunopathology: natural autoimmunity in human health and disease. Pathophysiology. 2012; 19 (3): 221–31. https://doi.org/10.1016/j.pathophys.2012.07.003
  15. Treshchinskaya M.A. Anti-aging effect of L-arginine. Meditsina neotlozhnykh sostoyaniy. 2012; (3): 50–4. (in Russian)
  16. Vanhoutte P.M. Arginine and Arginase: Endothelial NO Synthase Double Crossed? Circ Res. 2008; 102: 866–8. https://doi.org/10.1161/CIRCRESAHA.108.175570
  17. Shevchenko O.P., Slesareva Yu.S., Shevchenko A.O. РАРР-А and atherosclerotic plaque injury in patients with coronary heart disease. Rossiyskiy kardiologicheskiy zhurnal. 2011; 16 (2): 65–71. (in Russian)
  18. Kayumova G.Kh., Razin V.A. Pregnancy-associated plasma protein A, as instability analyzer atherosclerotic plaques in acute coronary syndromes. Ateroskleroz i dislipidemii. 2016; (2): 65–72. (in Russian)
  19. Volevodz N.N. Growth hormone and the cardiovascular system. Problemy endokrinologii. 2011; 57 (4): 37–47. (in Russian)
  20. Roshchupkin D.I., Fesenko E.E., Novoselov V.I. Organ Biophysics [Biofizika organov]. Mоcоw: Nauka; 2000. 255 p. (In Russian)
  21. Sukharevskaya T.M., Loseva M.I., Bolotnova T.V. Cell-membrane aspects of the pathogenesis of hypoxia in vibration disease from the effects of local vibration. Terapevticheskiy arkhiv. 1991; 2: 84–8. (in Russian)
  22. Vorob’eva V.V., Shabanov P.D. Pharmacology of vibration-mediated disorders of energy metabolism in myocardium. Obzory po klinicheskoy farmakologii i lekarstvennoy terapii. 2011; (1): 3–43. (in Russian)
  23. Oganesyan K.R., Oganisyan A.O., Gukasyan L.E. Lipid peroxidation upon combined exposure to vibration and liquorice preparations. Gigiyena i sanitariya [Hygiene and Sanitation, Russian journal]. 2008; (3): 80–1. (in Russian)
  24. Litovskaya A.V., Egorova I.V. The state of the immune system working under the influence of biological, chemical and physical factors. Meditsina truda i promyshlennaya ekologiya [Russian Journal of Occupational Health and Industrial Ecology]. 2000; (2): 8–11. (in Russian)
  25. Dong R.G., Welcome D.E., McDowell T.W., Xu X.S., Krajnak K., Wu J.Z. A Proposed Theory on Biodynamic Frequency Weighting for Hand-Transmitted Vibration Exposure. Ind Health. 2012; 50: 412–24. https://doi.org/10.2486/indhealth.MS1380
  26. Rosén B., Bjorkman A., Lundborg G. Improving hand sensibility in vibration induced neuropathy: A case-series. J Occup Med Toxicol. 2011; 6: 13–8. https://doi.org/10.1186/1745-6673-6-13
  27. Suvorov I.M., Agafonova T.A. Variability ol hear! rhythm in patients with vibration disease caused by local vibration. Meditsina truda i promyshlennaya ekologiya [Occupational health and industrial ecology]. 2004; (12): 14–6. (in Russian)
  28. Laskar S.M., Iwamoto M., Nakamoto M., Koshiyama H., Harada N. Heart rate variation and urinary catecholamine excretion in response to acute psychological stress in hand-arm vibration syndrome patients. J Occup Health. 2004; 46 (2): 125–31.
  29. Budanova V.A., Kulyutsin A.V., Luk’yanova M.V., Oleynikov V.E. Cardioselective beta-blockers: clinical efficiency in hypertensive patients. Arterial’naya gipertenziya. 2009; 15 (4): 445–9. (in Russian)
  30. Steinberg S.F. Beta1-Adrenergic Receptor Regulation Revisited. Circ Res. 2018; 123 (11): 1199–201. https://doi.org/10.1161/CIRCRESAHA.118.313884
  31. Kostyukevich M.V., Zykov K.A., Mironova N.A., Agapova O.Yu., Shevelev A.Ya., Efremov E.E. et al. Role of Autoantibodies Against β1-Adrenergic Receptor in Cardiovascular. Kardiologiya. 2016; (12): 82–91. https://doi.org/10.18565/cardio.2016.12.82-91 (in Russian)

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2019 Masnavieva L.B., Kudaeva I.V., Kuznetsova Y.A., Naumova O.V.


СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 37884 от 02.10.2009.