Evaluation of the cytokines response in the organism of cursors of the higher education institution at adaptation to the conditions of education

Introduction. Changes in a number of cytokines are shown not only during inflammation: during physical exertion or stress; moderate hypoxia

Material and methods. We evaluated the rates of interleukins 6 and 8 and white blood among cadets of a military educational institution during adaptation, dividing into 2 stages: initial, 2 and 3 months of observation, as well as the pre-seasonal - rise-decrease in the incidence of respiratory diseases (4-6 months). By the response of white blood, the state of non-specific adaptive reactions of the body was assessed.

Results. When IL-6 level was within normal limits, it increased 1.5 times after 2 months (not significantly), which was probably due to a stress response. During this period, adequate adaptive processes proceeded, confirmed by indices of the absolute content and percentage of lymphocytes characterizing non-specific adaptive responses of the body. The average IL-8 was within normal limits. However, in 9.1% of individuals, it initially exceeded or was at the level of the upper limit of normal; in the pre-season period it increased by 29.1% ((p = 0.042): an increase of 63.6%, of which 42.5% - to the level of the upper limit of the norm or above it. In 30.0%, the leukocytes were above the norm, which proved the infection of the team members. At the peak and with a decrease in the incidence of interleukin, IL-6 increased within normal limits, IL-8 decreased. IL-8 exceeded the norm in patients and individuals after clinical recovery. A group of persons was determined in whom it spent 4-6 months of observation within the upper limit of the norm or exceeded it. Among them were people who did not apply for illness. The second group of individuals with no signs of disease, but with high IL-8 values, was isolated in the pre-season period.

Conclusion. An increase within the normal range of IL-6 is not enough to cause acute systemic inflammatory effects. Determination of individual indices of IL-8 allows using as a prognostic criterion for exacerbation of the epidemiological situation for respiratory diseases.