Chromato-mass spectrometric identification of asymmetric dimethylhydrazine and its derivatives in environmental objects and biological media in the population residing near the fall areas of separated rocket vehicles parts
- Authors: Alekseev V.B.1, Ulanova T.S.1, Nurislamova T.V.1, Popova N.A.1, Maltseva O.A.1
-
Affiliations:
- Federal Scientific Center for Medical and Preventive Health Risk Management Technologies’ of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing
- Issue: Vol 99, No 8 (2020)
- Pages: 773-779
- Section: ENVIRONMENTAL HYGIENE
- Published: 14.09.2020
- URL: https://rjsocmed.com/0016-9900/article/view/639610
- DOI: https://doi.org/10.47470/0016-9900-2020-99-8-773-779
- ID: 639610
Cite item
Full Text
Abstract
Introduction. The issue of presence/absence of the consequences of technogenic space and rocket activity over the long period is on the agenda of the professional, social, and political communities, especially in regions were the certain territories have been appointed as the fall areas for the separated rocket vehicles parts, including the Republic of Altai.
Aim of study. Identification of the chemical composition of snow samples, drinking water, and blood in the population residing in the fall areas of the separated rocket vehicle parts in the Republic of Altai.
Material and methods. Identification of the chemical composition has been performed along with the quantitative determination of the content of N-nitrosamines in blood samples (n=50) in n the population who constantly live near to the fall areas of the separated rocket vehicles, as well snow samples (n=7), and drinking water (n=9). The samples were examined by a hybrid method using an Agilent gas chromatograph with a quadrupole mass spectrometric detector. In order to decrypt the results of the mass spectrometric analysis, we used the NIST Mass Spectrometry Data Library 08.L, WILEY275.L, PMW_TOX2.L., libraries of the United States Environmental Protection Agency, narcotic, herbal, toxic and contaminated substances. The quantitative determination of N-nitrosamines in the blood samples was performed by the method of chromatography-mass spectrometry.
Results. During the library search, 94% of the studied blood samples in the population registered substances that can be identified as unsymmetric dimethylhydrazine and 6% of the samples contain its decomposition product N-nitrosodimethylamine. However, the probability of categorizing these impurities to the desired substances was of 4-26%. In the blood samples of residents in whom there were identified asymmetric dimethylhydrazine and N-NDMA by quantitative chromatography-mass spectrometric analysis, the tag (Alt+2) N-nitrosodimethylamine and N-nitrosodiethylamine was found in the concentration range of 0.00095-0.346 mg/dm3. In 100% of the studied drinking water samples, residual amounts of asymmetric dimethylhydrazine were identified with a low probability of matching the library mass spectrum of 12-33%.
Conclusion. The conducted chromatography-mass spectrometry studies of snow samples, samples of the water, and blood of the population living near to the fall area of the separated rocket vehicle parts in the Republic of Altai allowed establishing the signs of residual quantities of dimethylhydrazine and N-nitrozodimethylamine.
About the authors
Vadim B. Alekseev
Federal Scientific Center for Medical and Preventive Health Risk Management Technologies’ of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing
Author for correspondence.
Email: noemail@neicon.ru
ORCID iD: 0000-0001-5850-7232
Russian Federation
Tatyana S. Ulanova
Federal Scientific Center for Medical and Preventive Health Risk Management Technologies’ of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing
Email: noemail@neicon.ru
ORCID iD: 0000-0002-9238-5598
Russian Federation
Tatyana V. Nurislamova
Federal Scientific Center for Medical and Preventive Health Risk Management Technologies’ of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing
Email: nurtat@fcrisk.ru
ORCID iD: 0000-0002-2344-3037
MD, Ph.D., DSci., DSci., Deputy Head of the Department of Chemical and Analytical Research of the Federal Scientific Center for Medical and Preventive Technologies for Risk Management of a Healthy Population Russia, Perm, 614045, Russian Federation.
e-mail: nurtat@fcrisk.ru
Russian FederationNina A. Popova
Federal Scientific Center for Medical and Preventive Health Risk Management Technologies’ of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing
Email: noemail@neicon.ru
ORCID iD: 0000-0002-9730-9092
Russian Federation
Olga A. Maltseva
Federal Scientific Center for Medical and Preventive Health Risk Management Technologies’ of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing
Email: noemail@neicon.ru
ORCID iD: 0000-0001-7664-3270
Russian Federation
References
- Bratkov A.A., Seregin E.P., Gorenkov A.F. Chemmotology of Rocket and Jet Fuels [Khimmotologiya raketnykh i reaktivnykh topliv]. Moscow: Khimiya; 1987. (in Russian)
- Krichevskiy S.V. Ecological safety and ecological policy of aerospace activity (relevant questions of the recent history). In: Abstracts of Papers. Institute of history of Natural Science and Technology of the Russian Academy of Sciences: Annual Scientific Conference [Tezisy dokladov IIET RAN: godichnaya nauchnaya konferentsiya]. Moscow: Dipol’-T, 2003: 433-5. (in Russian)
- Krichevskiy S.V. Ecological policy and ecological safety of rocket-space activity (methodological and practical aspects). Konversiya v mashinostroenii. 2006; (2): 32-6. (in Russian)
- Kasimov N.S., Vorozheykin A.P., Koroleva T.V., Krechetov P.P., Proskuryakov Yu.V. Rocket-Space Activities as the Source of Environmental Impact. Geografiya, obshchestvo, okruzhayushchaya sreda. 2004; 4: 467-74. (in Russian)
- Adushkin V.V., Kozlov S.I., Petrova A.V., eds. Ecological Problems and Risk of the Impact of Rocket-Space Technics on the Environment: Handbook [Ekologicheskie problemy i riski vozdeystviya raketno-kosmicheskoy tekhniki na okruzhayushchuyu prirodnuyu sredu: Spravochnoe posobie]. Moscow: Ankil; 2000. (in Russian)
- Schmidt E.W. Hydrazine and its Derivatives. New York: John Wiley & Sons; 2001.
- Kenessov В., Alimzhanova M., Sailaukhanuly Ye., Baimatova N., Abilev M., Batyrbekova S., et al. Transformation products of 1,1-dimethylhydrazine and their distribution in soils of fall places of rocket carriers in Central Kazakhstan. Sci. Total. Environ. 2012; 427-428: 78-85. https://10.1016/j.scitotenv.2012.04.017
- Bastrakov S.I., Nikolaev A.P. Risk assessment of the quality of drinking water for the health of the population. Sanitarnyy vrach. 2013; (3): 9-10. (in Russian)
- Krechetov P.P., Koroleva T.V., Kondrat’ev A.D. Asymmetric Dimethylhydrazine as a Factor of Impact on the Environment in the Implementation of Rocket and Space Activities [Nesimmetrichnyy dimetilgidrazin kak faktor vozdeystviya na okruzhayushchuyu prirodnuyu sredu pri osushchestvlenii raketno-kosmicheskoy deyatel’nosti]. Moscow: Pelikan; 2008. (in Russian)
- Klyuev N.A., Brodskiy E.S. Modern methods of mass spectrometric analysis of organic compounds. Rossiyskiy khimicheskiy zhurnal (Zhurnal Rossiyskogo khimicheskogo obshchestva im. D.I. Mendeleeva). 2002; 46(4): 57-63. (in Russian)
- Meshkov N.A. Principles of evaluation of the space rocket activity influence on health of the population living close to the regions of the fall of carrier rocket parts. Ekologiya. 2009; 10(4): 57-80. (in Russian)
- Onishchenko G.G. Influence of the environment state on the health of the population. unsolved problems and tasks. Gigiena i sanitariya. 2003; 82(1): 3-10. (in Russian)
- Rakhmanin Yu.A., Malysheva A.G. The concept of the development of the state of chemical-analytical environmental monitoring. Gigiena i sanitariya. 2013; 92(6): 4-9. (in Russian)
- Belov A.A. On the question of the toxicity and hazards of hydrazine and its derivatives. Sovremennye problemy toksikologii. 2000; (1): 25-33. (in Russian)
- Malysheva A.G, Rakhmanin Yu.A. Physical and Chemical Research and Methods of Substance Control in Environmental Hygiene [Fiziko-khimicheskie issledovaniya i metody kontrolya veshchestv v gigiene okruzhayushchey sredy]. St. Petersburg: Professional; 2012. (in Russian)
- Onishchenko G.G. On measures to reduce the negative impact of man-made environmental pollution. In: Materials of the 3rd Meeting of the National Environmental Forum [Materialy 3-go soveshchaniya Obshchenatsional’nogo Ekologicheskogo Foruma]. Volgograd – Perm’; 2001. (in Russian)
- Ulanova T.S. Scientific and methodological bases of chemical and analytical support of hygienic and medico-biological research in human ecology: Diss. Мoscow; 2006. (in Russian)
- Onishchenko G.G., Rakhmanin Yu.A., Zaytseva N.V., Zemlyanova M.A., Akatova A.A. Scientific and Methodological Aspects of Ensuring Hygienic Safety of the Population under the Influence of Chemical Factors [Nauchno-metodicheskie aspekty obespecheniya gigienicheskoy bezopasnosti naseleniya v usloviyakh vozdeystviya khimicheskikh faktorov]. Moscow: Meditsinskaya kniga; 2004: 109-19. (in Russian)
- Fortin D.T., Chen R. Developing a trace level GC-MS method for detecting methylhydrazine in an experimental drug substance. J. Chromatogr. Sci. 2010; 48(4): 299-302. https://10.1093/chromsci/48.4.299
- Buryak A.K., Tataurova O.G., Ul’yanov A.V. Investigation of the transformation products of unsymmetrical dimethylhydrazine in model sorbents by gas chromatography/mass spectrometry. Mass-spektrometriya. 2004; 1(2): 147-52. (in Russian)
- IARC Monographs on the Evaluation of Carcinogenic Risks for Humans. Volume 52. Lyon: 1991.
- WHO. Biomarkers and Human Biomonitoring. Children’s Health and the Environment WHO Training Package for the Health Sector; 2011.
- Budnikov G.K. Trace analysis as the problem of modern analytic chemistry. Sorosovskiy obrazovatel’nyy zhurnal. 2000; 6(3): 45-51. (in Russian)
- Krylov A.I. Development and improvement of methods for identification and determination of organic analytes in samples of unknown composition: Diss. St. Petersburg; 2012. (in Russian)
- Methodical Instruction 4.1. 3479-17. Measurement of mass concentrations of n-nitrosoamines (n-nitrosodimethylamine, n-nitrosodiethylamine) in blood by capillary gas chromatography method. Moscow; 2017. (in Russian)
- Methodical Instruction 4.1.1871-04. Gas chromatographic determination of n-nitrosodimethylamine (NDMA) in drinking water and water bodies. Moscow; 2004. (in Russian)
- Hygienic Standards 2.1.5.1315-03. Maximum permissible concentrations (MPC) of chemical substances in the water of water bodies of economic and drinking cultural and household water use. Moscow; 2003. (in Russian)
- Fan J., Kong J., Feng S., Wang J., Peng P. Kinetic fluorimetric determination of trace hydrazine in environmental waters. Intern. J. Environ. Anal. Chem. 2006; 86(13): 995-1005.
- Sotnikov E.E., Moskovkin A.S. Gas chromatographic determination of asymmetric dimethylhydrazine in water. Zhurnal analiticheskoy khimii. 2006; 61(2): 139-42. (in Russian)
- Alimzhanova M.B., Doszhan G.N., Kenesov B.N., Batyrbekova S.E., Nauryzbaev M.K. Study of 1,1-dimethylhydrazine transformation processes in water in the presence of iron (iii), copper (ii) and manganese (ii) cations. Vestnik KazNU im. al’-Farabi. Seriya khimicheskaya. 2009; 54(2): 139-43. (in Russian)
Supplementary files
