Possible mechanism of the implementing the trigger role of air pollution in rheumatoid arthritis (preliminary data)
- Authors: Takha E.A.1, Larionova R.V.1,2, Petrov S.V.1,2, Kazarian G.G.1, Valeeva A.R.1, Korovina M.O.1,2, Shamaev N.D.2, Pipchenko A.P.2, Renaudineau Y.3, Kravtsova O.A.2, Khaertynov K.S.1,4, Badrutdinov O.R.2, Mukminov M.N.1,2, Shuralev E.A.1,2,5, Arleevskaya M.I.1,2
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Affiliations:
- KSMA - Branch Campus of the FSBEI FPE RMACPE MOH Russia
- Kazan Federal University
- Universite Toulouse III - Paul Sabatier
- Federal Center for Toxicological, Radiation and Biological Safety
- Kazan State Academy of Veterinary Medicine named after N.E. Bauman
- Issue: Vol 101, No 2 (2022)
- Pages: 139-145
- Section: ENVIRONMENTAL HYGIENE
- Published: 16.03.2022
- URL: https://rjsocmed.com/0016-9900/article/view/639402
- DOI: https://doi.org/10.47470/0016-9900-2022-101-2-139-145
- ID: 639402
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Full Text
Abstract
Introduction. Currently, there is evidence of a triggering role of environmental factors in developing rheumatoid arthritis (RA).
The purpose of this work was to investigate the role of oxidative stress in provoking the preclinical stage of RAf in susceptible individuals and its possible relationship with the effects of ecotoxicants.
Materials and methods. Examination of cases collecting biosamples was carried out during rheumatologic examination of the persons in the regional hospitals of 45 administrative districts of the Republic of Tatarstan (RT), Russia. Serum markers of oxidative stress were measured, namely levels of oxidized proteins, oxidized lipids, oxyguanine, and antibodies to oxidized LDL. The environmental parameters of residences of the persons included in the project were measured. Information was collected on the parameters of the environmental situation in the administrative districts of the Republic of Tatarstan in 2008–2018 (from publicly available reports of the Ministry of Ecology of the Republic of Tatarstan).
Results. There was performed a comparison of the levels of oxidative markers in samples from individuals living in regions with the highest and lowest concentrations of certain atmosphere ecotoxicants, including carbon monoxide, hydrocarbons (volatile organic compounds (VOCs) free), particulate matter, VOCs, sulfur dioxide, and nitrogen oxide. The levels of oxidized proteins and oxidized LDL were significantly higher in residents of areas with the highest carbon monoxide and VOCs compared to residents of areas with the lowest content of these substances. The contribution of environmental indicators to the provocation of the anti-LDG antibody production in groups with genetic and preclinical RA stages was revealed to account for 40%. According to the results of multiple regression analysis, in individuals from the above groups and individuals at early RA stage, the levels of oxidized LDL and oxidized proteins depended on the effect of a combination of certain environmental factors.
Limitations. In this article, we limited ourselves to the analysis of the RA association with air pollution indices. The study of other environmental factors (soil, water pollution, radiation levels) is ongoing. This will allow clarifying the specific mechanisms of the influence of the exposome on the development of the disease in total. In addition, the conclusions presented are speculative since the identified patterns were obtained by analyzing data in the limited data samples.
Conclusion. Since environmental factors can be considered modifiable to a certain extent, the study of their role in the RA development and specific mechanisms of the disease triggered by these factors on persons at risk are of fundamental and applied importance.
Contribution:
Takha E.A., Larionova R.V., Petrov S.V. — сollection and processing of material, statistical processing, writing text, responsibility for the integrity of all parts of the article;
Kazarian G.G., Valeeva A.R., Korovina M.O., Pipchenko A.P., Kravtsova O.A., Badrutdinov O.R. — collection and processing of material, writing text;
Shamaev N.D. — collection and processing of material, statistical processing, writing text;
Renaudineau Y. — concept and design of the study, responsibility for the integrity of all parts of the article;
Kravtsova O.A. — collection and processing of material, writing text;
Khaertynov K.S. — editing, approval of the final version of the article, responsibility for the integrity of all parts of the article;
Mukminov M.N. — concept and design of the study, collection and processing of material, writing text, editing;
Shuralev E.A. — concept and design of the study, collection and processing of material, editing, approval of the final version of the article;
Arleevskaya M.I. — concept and design of the study, collection and processing of material, statistical processing, writing text, approval of the final version of the article, responsibility for the integrity of all parts of the article. All authors are responsible for the integrity of all parts of the manuscript and approval of the manuscript final version.
Conflict of interest. The authors declare no conflict of interest.
Acknowledgment. The reported study was funded by Russian Foundation for Basic Research (RFBR) according to the research project 19-29-01058.
Received: August 03, 2021 / Accepted: November 25, 2021 / Published: March 10, 2022
About the authors
Elena A. Takha
KSMA - Branch Campus of the FSBEI FPE RMACPE MOH Russia
Author for correspondence.
Email: noemail@neicon.ru
ORCID iD: 0000-0001-9932-8417
Russian Federation
Regina V. Larionova
KSMA - Branch Campus of the FSBEI FPE RMACPE MOH Russia; Kazan Federal University
Email: noemail@neicon.ru
ORCID iD: 0000-0002-0651-0728
Russian Federation
Sergei V. Petrov
KSMA - Branch Campus of the FSBEI FPE RMACPE MOH Russia; Kazan Federal University
Email: noemail@neicon.ru
ORCID iD: 0000-0002-8930-8129
Russian Federation
Gevorg G. Kazarian
KSMA - Branch Campus of the FSBEI FPE RMACPE MOH Russia
Email: noemail@neicon.ru
ORCID iD: 0000-0001-6422-8299
Russian Federation
Anna R. Valeeva
KSMA - Branch Campus of the FSBEI FPE RMACPE MOH Russia
Email: noemail@neicon.ru
ORCID iD: 0000-0001-5218-9341
Russian Federation
Marina O. Korovina
KSMA - Branch Campus of the FSBEI FPE RMACPE MOH Russia; Kazan Federal University
Email: noemail@neicon.ru
ORCID iD: 0000-0002-2307-928X
Russian Federation
Nikolai D. Shamaev
Kazan Federal University
Email: noemail@neicon.ru
ORCID iD: 0000-0002-0575-3760
Russian Federation
Anna P. Pipchenko
Kazan Federal University
Email: noemail@neicon.ru
ORCID iD: 0000-0003-1783-0337
Russian Federation
Yves Renaudineau
Universite Toulouse III - Paul Sabatier
Email: noemail@neicon.ru
ORCID iD: 0000-0001-5098-5002
France
Olga A. Kravtsova
Kazan Federal University
Email: noemail@neicon.ru
ORCID iD: 0000-0002-4227-008X
Russian Federation
Kamil S. Khaertynov
KSMA - Branch Campus of the FSBEI FPE RMACPE MOH Russia; Federal Center for Toxicological, Radiation and Biological Safety
Email: noemail@neicon.ru
ORCID iD: 0000-0003-4764-560X
Russian Federation
Oleg R. Badrutdinov
Kazan Federal University
Email: noemail@neicon.ru
Russian Federation
Malik N. Mukminov
KSMA - Branch Campus of the FSBEI FPE RMACPE MOH Russia; Kazan Federal University
Email: noemail@neicon.ru
Russian Federation
Eduard A. Shuralev
KSMA - Branch Campus of the FSBEI FPE RMACPE MOH Russia; Kazan Federal University; Kazan State Academy of Veterinary Medicine named after N.E. Bauman
Email: noemail@neicon.ru
Russian Federation
Marina I. Arleevskaya
KSMA - Branch Campus of the FSBEI FPE RMACPE MOH Russia; Kazan Federal University
Email: marleev@mail.ru
MD, PhD, Senior Researcher of Central Research Lab of Kazan State Medical Academy — Branch Campus of the Russian Medical
Academy of Continuous Professional Education, Kazan, 420012, Russian Federation.
e-mail: marleev@mail.ru
Russian FederationReferences
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