Methodological approaches to the assessment of health risks associated with the use of repellent and insecticide agents

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Abstract

Introduction. The study’s relevance is due to the demand for repellent and insecticidal agents in the consumer market and their widespread use as protection against mosquitoes. At the same time, the problem of the impact on the human health of these funds has not been sufficiently studied. In this regard, analyzing the safety of repellents and insecticides for human health is of scientific interest. 

The aim of the study is to substantiate methodological approaches to assessing the risk to human health associated with the use of insecticides and repellents. 

Materials and methods. Authors used methods of analysis of scientific literature, toxicological methods for the study of health safety, methods of quantitative chemical analysis, biochemical methods for the study of blood serum, methods of mathematical modeling, health risk assessment methodology. 

Results. The assessment of the risk of negative responses from organs and systems of the body when exposed to repellents and insecticides has been carried out. Methodological approaches to assessing health risks under various scenarios for repellents and insecticides have been developed and tested. 

Conclusion. A feature of the proposed methodological approaches is the ability to take into account dose loads for various routes of entry of active substances into the body, the duration of exposure to a repellent or insecticide during regular use, and possible use in regimes exceeding normal use. As a result of the experiment, it was found that with the inhalation of an insecticide with 1% transfluthrin, the level of acceptable risk is observed at a level of exposure of transfluthrin in the air up to 0.0272 mg/m3. Under a percutaneous intake of the 50% DEET repellent, the acceptable risk level was noted at exposure less than 1200 mg/kg/day. In case of percutaneous arrival of the DETA repellent 7.5%, the level of acceptable risk is established under exposure up to 250 mg/kg/day.

About the authors

Pavel Z. Shur

Federal Scientific Center for Medical and Preventive Health Risk Management Technologies

Author for correspondence.
Email: noemail@neicon.ru
ORCID iD: 0000-0001-5171-3105
Russian Federation

Nina V. Zaitseva

Federal Scientific Center for Medical and Preventive Health Risk Management Technologies

Email: noemail@neicon.ru
ORCID iD: 0000-0003-2356-1145
Russian Federation

Svetlana V. Redko

Federal Scientific Center for Medical and Preventive Health Risk Management Technologies

Email: redkosv@fcrisk.ru
ORCID iD: 0000-0002-2736-5013

MD, Ph.D., Senior Researcher, Laboratory of Environmental Risk Analysis Methods, Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, Perm, 614045, Russian Federation.

e-mail: redkosv@fcrisk.ru

Russian Federation

Arina I. Vinogradova

Scientific Research Disinfectology Institute

Email: noemail@neicon.ru
ORCID iD: 0000-0002-3253-4571
Russian Federation

Vladimir A. Fokin

Federal Scientific Center for Medical and Preventive Health Risk Management Technologies

Email: noemail@neicon.ru
ORCID iD: 0000-0002-0539-7006
Russian Federation

Marina V. Bidevkina

Scientific Research Disinfectology Institute

Email: noemail@neicon.ru
ORCID iD: 0000-0001-6433-899X
Russian Federation

Anna A. Khasanova

Federal Scientific Center for Medical and Preventive Health Risk Management Technologies

Email: noemail@neicon.ru
ORCID iD: 0000-0001-7438-0358
Russian Federation

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