Changes in biochemical parameters in children exposed to objects of accumulated environmental damage

Introduction. At present, the assessment and evidence of the impact of objects of accumulated environmental damage on the health of the population, primarily children, is extremely relevant, which is reflected in the priority goals of the Federal Project “General Cleaning”. 

The purpose of the study is to evaluate the changes in some biochemical indicators of negative effects in children exposed to objects of the former production of chemical products. 

Materials and methods. Risk assessment, chemical-analytical, biochemical and general clinical studies, statistical analysis were carried out. 

Results. In children exposed to objects of the former production of chemical products, relative to the comparison group, there were identified, toxic metabolites of epichlorohydrin, elevated concentrations of phenol, benzo (a) pyrene, manganese, nickel, lead, arsenic, chromium, zinc in the blood, mercury, cadmium, arsenic in the urine; more frequent registration of the development of negative effects was revealed, indicating a more pronounced development of general and specific sensitization to nickel and hypersensitivity to benzo(a)pyrene, mercury, phenol; a decrease in the filtering ability of the kidneys, the development of functional disorders of the liver and biliary tract, an increase in the synthesis of neurotransmitters and a violation of the neuro-endocrine regulation of the stress state associated with the negative impact of chemical risk factors. 

Limitations. The conducted study takes into account the influence of only chemical factors of accumulated environmental damage on the health of the child population aged 3-6 years.

Conclusion. The relationship between public health disorders and the impact of factors of accumulated environmental damage as a result of the former economic activity for the production of chemical products was identified and evaluated. 

Compliance with ethical standards. The study was approved by the Local Ethics Committee of the “Federal Scientific Center for Medical and Preventive Technologies for Risk Management of the Russian Federation” of the Federal Service for Supervision in Protection of the Rights of Consumer and Man Wellbeing, conducted according to the generally accepted scientific principles of the Helsinki Declaration of the World Medical Association (2013).

Contribution:
Zemlyanova M.A. — the research concept and design, editing;
Zaitseva N.V. — the research concept and design, approval of the final version of the article;
Koldibekova Yu.V. — the concept and design of the study, statistical processing of the material, writing the text;
Pustovalova O.V. — collection and processing of material. 
All authors are responsible for the integrity of all parts of the manuscript and approval of the manuscript final version.

Conflict of interest. The authors declare no conflict of interest.

Acknowledgement. The study had no sponsorship.

Received: April 11, 2022 / Accepted: June 8, 2022 / Published: June 26, 2022